ASSOCIATION AMONG HISTOLOGICAL FINDINGS SUGGESTIVE OF PAPILLOMA VIRUS ON HEMORRHOIDECTOMY SPECIMENS

Background: Many researchers studied human Papillomavirus infection in the anal area supposing it represents a risk factor for precursor lesions of anal cancer. Aim: To study the association between histological findings suggestive of injury by the virus in hemorrhoidectomy specimens. Method: Prevalence study was carried out based on histopathological analysis of hemorrhoidectomy specimens to find viral cytopathic effects. These findings were compared with anal condyloma acuminata that had no relationship with hemorrhoidectomy for microscopic comparison. Results: Of the 91 hemorroidectomies analyzed, eight had findings suggestive of viral cytopathic effects, with the presence of irregular acanthosis in 63%, koilocytes in 50% and other indirect viral cytopathic effects, such as hyperkeratosis (38%), parakeratosis (25% ) and papillomatosis (13%). Conclusion: This study was unable to conclude that there is an association between these two pathologic entities.

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Association Between Human Papillomavirus Infection and Anus Cancer Precursor Lesions: A Review

Proceedings of the 5th Brazilian Technology Symposium - Smart Innovation, Systems and Technologies ◽

10.1007/978-3-030-57566-3_8 ◽

2020 ◽

pp. 83-90

Author(s):

Ana Carolina Borges Monteiro ◽

Yuzo Iano ◽

Reinaldo Padilha França ◽

Rangel Arthur ◽

Pablo David Minango Negrete ◽

...

Keyword(s):

Human Papillomavirus ◽

Precursor Lesions ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Overexpression of the proto-oncogene C-jun in association with low-risk type specific human papillomavirus infection in condyloma acuminata

Journal of Medical Virology ◽

10.1002/(sici)1096-9071(199604)48:4<302::aid-jmv2>3.0.co;2-b ◽

1996 ◽

Vol 48 (4) ◽

pp. 302-307 ◽

Cited By ~ 8

Author(s):

Yung-Fu Yang ◽

Yu-Ping Tsao ◽

Chang-Shen Yin ◽

Show-Li Chen ◽

Tang-Yuan Chu

Keyword(s):

Human Papillomavirus ◽

Condyloma Acuminata ◽

Low Risk ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Association between human papillomavirus infection and atypical cervical squamous cells

Medicinski pregled ◽

10.2298/mpns1810301d ◽

2018 ◽

Vol 71 (9-10) ◽

pp. 301-308

Author(s):

Drage Dabeski

Keyword(s):

Human Papillomavirus ◽

Squamous Cell ◽

Cross Sectional Study ◽

Histopathological Analysis ◽

Cervical Lesions ◽

Cross Sectional ◽

Squamous Cells ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Gynecology And Obstetrics

Introduction. The aim of the study was to confirm the association between human papillomavirus infection and atypical cervical squamous cells. Material and Methods. This cross-sectional study, conducted in the period from January 2016 to June 2017, included 128 sexually active women, aged 20 to 59 years with squamous cell abnormalities of the cervical cytology, who came to their annual gynecological exam at the University Clinic of Gynecology and Obstetrics in Skopje. All patients underwent human papillomavirus testing and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. Results. Data analysis showed an increase in the human papillomavirus infection alongside with cytological (p = 0.029296) and histopathological (p = 0.029443) increasing grades of cervical lesions. It showed an association between the oncogenic potential of the virus and the cytological (p = 0.000086) and histopathological (p = 0.00001) grades of cervical lesions. A human papillomavirus infection was detected in 75.00% of the examined women. The relationship between the prevalence of high-risk and low-risk human papillomavirus genotypes was 56.25%: 10.94%. Mixed human papillomavirus infection was detected in 32.03% of all patients, in 42.71% of human papillomavirus positive patients. The most common human papillomavirus genotypes, in descending order, were human papillomavirus-16 (43.75%), human papillomavirus-31 (15.62%), human papillomavirus-18 10.4%), human papillomavirus-45 (9.37%), human papillomavirus-33 (7.29%), etc. Conclusion. This study has confirmed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Young women under 30 years of age were the most affected group.

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Role of histological findings and pathologic diagnosis for detection of human papillomavirus infection in men

Journal of Medical Virology ◽

10.1002/jmv.24238 ◽

2015 ◽

Vol 87 (10) ◽

pp. 1777-1787 ◽

Cited By ~ 3

Author(s):

Nikki S. Vyas ◽

Christine M. Pierce Campbell ◽

Rahel Mathew ◽

Martha Abrahamsen ◽

Kaisa Van der Kooi ◽

...

Keyword(s):

Human Papillomavirus ◽

Histological Findings ◽

Pathologic Diagnosis ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Association of human papillomavirus infection with carcinoma of the cervix uteri and its precursor lesions: theoretical and practical implications

Virchows Archiv ◽

10.1007/s004280000234 ◽

2000 ◽

Vol 437 (3) ◽

pp. 227-233 ◽

Cited By ~ 20

Author(s):

Karin Milde-Langosch ◽

Sabine Riethdorf ◽

T. Löning

Keyword(s):

Human Papillomavirus ◽

Cervix Uteri ◽

Precursor Lesions ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Practical Implications

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Cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : A frequency study

Diagnostic Cytopathology ◽

10.1002/dc.21656 ◽

2011 ◽

Vol 40 (10) ◽

pp. 871-875 ◽

Cited By ~ 3

Author(s):

Nadja Lindany Alves de Sousa ◽

Rosane Ribeiro Figueiredo Alves ◽

Marcelo Rodrigues Martins ◽

Narriman Kennia Da Silva Barros ◽

Andrea Alves Ribeiro ◽

...

Keyword(s):

Human Papillomavirus ◽

Cervical Intraepithelial Neoplasia ◽

Intraepithelial Neoplasia ◽

Cytopathic Effects ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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Human papillomavirus infection and cervical cancer precursor lesions in women living by Amazon rivers: investigation of relations with markers of oxidative stress

Einstein (São Paulo) ◽

10.1590/s1679-45082018ao4190 ◽

2018 ◽

Vol 16 (3) ◽

Cited By ~ 2

Author(s):

Bruna Emanuelle Sanches Borges ◽

Elza Baia de Brito ◽

Hellen Thais Fuzii ◽

Cláudia Simone Baltazar ◽

Aline Barreto Sá ◽

...

Keyword(s):

Oxidative Stress ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Low Grade ◽

Oxidized Glutathione ◽

Precursor Lesions ◽

Total Glutathione ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Significant Difference

ABSTRACT Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions. Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels. Results Malondialdehyde, total and oxidized glutathione concentrations did not differ significantly (p>0.05) between women with and without low-grade squamous intraepithelial lesions across communities. Malondialdehyde levels (8.02nmols/mL) were almost five times higher in human papillomavirus-positive compared to human papillomavirus-negative women (1.70nmols/mL) living in Itaituba (statistically significant difference; p<0.05). Malondialdehyde levels did not differ significantly (p>0.05) between human papillomavirus-positive and human papillomavirus-negative women living in remaining communities. Significant (p<0.05) differences in total glutathione levels between human papillomavirus-positive and human papillomavirus-negative women (8.20μg/mL and 1.47μg/mL, respectively) were limited to those living in Bragança. Conclusion Malondialdehyde and total glutathione levels were significantly associated with human papillomavirus infection. However, lack of similar associations with squamous lesions suggest oxidative stress alone does not explain correlations with cervical carcinogenesis. Other factors may therefore be involved.

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