Ligation of the abdominal esophagus decreases scorpion toxin-induced gastric secretion in rats

PURPOSE: Scorpion toxin purified from Tityus serrulatus venom (Tx) induces an increase in volume, acidity and pepsin secretion in the gastric juice of rats. Ligation of oesophagus has been shown to reduce the acid gastric secretion in rats. The aim of this paper was to determine the influence of the esophageal ligation on gastric secretion induced by Tx in rats METHODS: Forty-four male albino rats were given water ad libitum, but no food for 20 to 24 hours, anesthetized with urethane and the trachea and jugular vein cannulated. Cervical or abdominal esophageal ligation or sham-operations were performed before and after the injection of 0.25 mg/kg of scorpion toxin (fraction T1) into the jugular vein. One hour later, the volume, acidity, pH and peptic activity of gastric juice were determined. RESULTS: The scorpion toxin induced an increase in gastric juice volume, acidity and pepsin output and a decrease in pH when injected into the vein of intact animals or in sham-operated animals. Cervical esophagus ligation did not interfere with the effects of toxin, however, ligation of the abdominal esophageal decreased the toxin effect on the rat stomach. CONCLUSION: Ligation of the abdominal esophagus decreases the gastric secretion induced by scorpion toxin.

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Excretion of Free Histamine in Urine During Gastric Secretion Stimulated by Humoral Mechanisms

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1958.195.1.197 ◽

1958 ◽

Vol 195 (1) ◽

pp. 197-201 ◽

Cited By ~ 6

Author(s):

Edwin H. Updike ◽

Charles F. Code ◽

George A. Hallenbeck

Keyword(s):

Gastric Secretion ◽

Gastric Juice ◽

Temporal Correlation ◽

Gastric Antrum ◽

Meat Meal ◽

Before And After ◽

Urinary Histamine

This study was done to determine whether, after a meat meal, the outputs of acid in gastric juice and free histamine in urine are related and whether the output of free urinary histamine is increased after transplantation of the gastric antrum to the colon. Dogs with separated gastric pouches (Heidenhain) were used. Gastric juice and urine were collected at hourly intervals before and after the ingestion of the meal and for 24-hour periods before and after transplantation of the gastric antrum to the colon. Similar collections were made when histamine was injected intravenously at different rates. A rough temporal correlation was found between the outputs of HCl in gastric juice and free histamine in the urine after the meal of meat. There was not a significant increase in the 24-hour output of free histamine in the urine of the dogs in which a modest hypersecretion developed following transplantation of the gastric antrum to the colon.

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Determination of Peptic Activity and Acid in the Gastric Juice of Patients with Peptic Disease Before and After Administration of Glycopyrrolate

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1966.tb02849.x ◽

2009 ◽

Vol 180 (4) ◽

pp. 385-394 ◽

Cited By ~ 4

Author(s):

Vibeke Bitsch ◽

Marie Kristensen

Keyword(s):

Gastric Juice ◽

Peptic Activity ◽

Peptic Disease ◽

Before And After

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Effect of scorpion toxin on the enterochromaffin-like cells in normal and Trypanosoma cruzi-infected rats: a morphological study

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651989000100002 ◽

1989 ◽

Vol 31 (1) ◽

pp. 7-13 ◽

Cited By ~ 1

Author(s):

N. H. Toppa ◽

V. H. R. Leite ◽

A. J. A. Barbosa ◽

E. Chiari ◽

H. M. S. Gonzaga ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Gastric Secretion ◽

Intravenous Injection ◽

Morphological Study ◽

Acute Infection ◽

Scorpion Toxin ◽

Ecl Cells ◽

Tityus Serrulatus ◽

Morphologic Changes

Intravenous injection of scorpion toxin (Tityus serrulatus) in normal and Trypanosoma cruzi infected rats did not cause ultrastructural morphologic changes on enterochromaffin-like (ECL) cells of the stomach, although it induced a significant increase of the gastric secretion. Our data seem to indicate that gastric ECL cells structure is not affected by stimulation with scorpion toxin or by acute infection with T. cruzi in the rat.

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Gastric osmolar clearance and ionic barter: two mechanisms of electrolyte secretion by the human stomach

Journal of Applied Physiology ◽

10.1152/jappl.1960.15.5.933 ◽

1960 ◽

Vol 15 (5) ◽

pp. 933-938 ◽

Cited By ~ 9

Author(s):

Basil I. Hirschowitz

Keyword(s):

Gastric Juice ◽

Chloride Ion ◽

Plasma Sodium ◽

Optimal Conditions ◽

Maximum Value ◽

Clearance Mechanism ◽

Before And After ◽

Na Ions ◽

Gastric Juice Volume ◽

Made In

Measurements of gastric juice volume (V) and H ion (H), chloride ion (ClG), Na ion (NaG) concentrations and of osmolality (OG) as well as plasma sodium (NaP) and osmolality (OP) were made in nine men before and after a subcutaneous injection of histamine. The gastric osmolar clearance (GOC) was calculated from the formula (V·OG)/OP and this correlated well with both acid and chloride output. The theoretical clearance of sodium (TCNa) was calculated for each specimen by the formula (V·OG·NaP)/OP, and this equaled the output of acid plus sodium in the gastric juice V(H + NaG). The mol-mol relationship furthermore suggests that the gastric acid is secreted on a 1:1 basis in exchange for Na ions theoretically cleared within the framework of a gastric osmolar clearance mechanism. It also explains why, even under the most optimal conditions in man, the maximum value for H+ concentration does not exceed 150 mEq/l. On the basis of these observations it is suggested that the various theories which propose a primary acid secretion of 167, 169, 208 or 464 mn, respectively, are unlikely. Submitted on January 22, 1960

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