The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats

PURPOSE: To assess the effect of repeated extracorporeal shock waves (ESW) on renal parenchyma of normal and diabetic rats. METHODS: 40 normal rats (A) and 40 diabetic rats (B) were assigned for ESW (Direx Tripter X1® - 14 KVA) as follow: A1/B1 and A3/B3 no ESW; A2/B2 one ESW (2,000 SW); A4/B4 two ESW (4,000 SW) in an elapsed 14 days. All the animals were sacrificed 3 days after the ESW and samples of renal parenchyma were histological prepared, stained by H&E. For each animal the frequency of hemorrhage focus (HF) in the subcapasular, interstitial and glomerulus area was calculated (porcentage) on 20 randomly histological sections. RESULTS: No one HF was identified in all normal or diabetic animals without ESW (A1, A3 and B1, B3). In the normal rats the HF frequency was similar to one ESW (subcapsular =15%; interstitial =20% and glomerular =10%) or repetead ESW (subcapsular =25%; interstitial =20%; glomerular=10%). In diabetic rats the occurence of HF with repetead ESW was more frequent (subcapsular =40%; interstitial =30% and glomerular =10%) than with a single ESW (subcapsular =25%; interstitial =15% and glomerular =15%). CONCLUSION: A single ESW or a repeated ESW caused a mild and similar damage on renal cortex of normal rats. In diabetic rats the repetead ESW may result in an accumulated damage, especially with focus of hemorrhage in subcapsular and interstitial tissue and glomerulus edema.

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Effects of extracorporeal shock waves on neuralgia in diabetic rats

Journal of Pain Research ◽

10.2147/jpr.s177585 ◽

2019 ◽

Vol Volume 12 ◽

pp. 387-394

Author(s):

Yue Zhou ◽

Hong Dai ◽

Juan Long ◽

Xin-Guo Kang ◽

Chun-Jing He

Keyword(s):

Shock Waves ◽

Diabetic Rats ◽

Extracorporeal Shock Waves

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Mentha pulegium Aqueous Extract Exhibits Antidiabetic and Hepatoprotective Effects in Streptozotocin-Induced Diabetic Rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666181005102247 ◽

2019 ◽

Vol 19 (3) ◽

pp. 292-301

Author(s):

Omar Farid ◽

Naoufel Ali Zeggwagh ◽

Fadwa EL Ouadi ◽

Mohamed Eddouks

Keyword(s):

Blood Glucose ◽

Glucose Tolerance ◽

Aqueous Extract ◽

Morphometric Analysis ◽

Diabetic Rats ◽

Mentha Pulegium ◽

Glucose Levels ◽

Histological Sections ◽

Blood Glucose Levels ◽

Liver And Pancreas

Objective: The aim of this work was to evaluate the antihyperglycemic activity of aerial parts aqueous extract (A.P.A.E) of Mentha pulegium (M. pulegium) on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rat. The glucose tolerance was evaluated in normal rats. Moreover, the histological sections and morphometric analysis at the liver and pancreas have been carried out in this investigation both in normal and STZ-diabetic rats. Methods: The effect of A.P.A.E of M. pulegium (20 mg/kg) on blood glucose levels was investigated in normal and diabetic rats (n=6). Histopathological changes in liver and pancreas were examined under phase contrast microscope and a preliminary screening for various bioactive constituents was realized according to standard methods. Key Findings: Both single and repeated oral administration of A.P.A.E (20 mg/kg) caused a significant reduction in blood glucose levels in STZ-diabetic rats (p<0.0001). The morphometric analysis and histological sections realized in pancreas and liver have showed the beneficial effect of the A.P.A.E in cellular population. According to oral glucose tolerance test (OGTT), the aqueous extract has revealed an improvement of glucose tolerance in normal rat. Furthermore, the preliminary phytochemical screening of A.P.A.E of M. pulegium has demonstrated the presence of various metabolite compounds including polyphenols, flavonoids, terpenoids tannins, cyanidins, sesquiterpenes, and glycosides. Conclusion: We conclude that the A.P.A.E of M. pulegium (20 mg/kg) exhibits a potent antihyperglycemic activity in STZ diabetic rats.

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Osteogenetic effect of extracorporeal shock waves in human

International Journal of Surgery ◽

10.1016/j.ijsu.2015.09.068 ◽

2015 ◽

Vol 24 ◽

pp. 115-119 ◽

Cited By ~ 9

Author(s):

L. Gerdesmeyer ◽

W. Schaden ◽

L. Besch ◽

M. Stukenberg ◽

L. Doerner ◽

...

Keyword(s):

Shock Waves ◽

Extracorporeal Shock Waves

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The In Vitro and In Vivo Effects of Extracorporeal Shock Waves on Tumor Cells

Shock Wave Lithotripsy ◽

10.1007/978-1-4757-1977-2_72 ◽

1988 ◽

pp. 351-355

Author(s):

Gerhard J. Fuchs ◽

Randall F. Randazzo ◽

Anna M. Fuchs ◽

Arnulf Stenzl ◽

Christian G. Chaussy

Keyword(s):

Shock Waves ◽

Tumor Cells ◽

Extracorporeal Shock Waves ◽

In Vivo Effects

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Experimental Effects of Extracorporeal Shock Waves on the Rat Ovary and Fetus

Shock Wave Lithotripsy ◽

10.1007/978-1-4757-1977-2_67 ◽

1988 ◽

pp. 327-328 ◽

Cited By ~ 1

Author(s):

David L. McCullough ◽

Leslie D. Yeaman ◽

Walter J. Bo ◽

Roy L. Kroovand ◽

Dean G. Assimos ◽

...

Keyword(s):

Shock Waves ◽

Extracorporeal Shock Waves ◽

Rat Ovary

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The effect of urinary tract calculosis to levels of low molecular inhibitors of crystallization in the urine

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0602040m ◽

2006 ◽

Vol 134 (1-2) ◽

pp. 40-43

Author(s):

Dragica Milenkovic ◽

Natasa Lalic

Keyword(s):

Urinary Tract ◽

Shock Waves ◽

Stone Formation ◽

Upper Urinary Tract ◽

Therapeutic Procedure ◽

Residual Stone ◽

Extracorporeal Shock Waves ◽

Urinary Levels ◽

Urinary Tract Stones ◽

Pre Treatment

The incidence of urinary tract calculosis continuously progresses. The triggering event in the process of stone formation is decreased urinary level of crystallizing inhibitors. The aim of our study was to investigate whether the existing stone or applied therapeutic procedure - extracorporeal shock waves lithotripsy (ESWL) - has effect to urinary levels of Mg, citrate and pyrophosphate. Study included 128 patients with the upper urinary tract stones. ESWL using the Lithostar (Siemens) device was used as a mode of treatment. Out of all patients, 76 (59%) were free of stone particles before 1 month, while 52 (41%) had residual stone fragments even 3 months after ESWL. Mg, citrate and pyrophosphate were measured in 24hurine specimens: before, between days 2 and 3, as well as 1 and 3 months after ESWL. The analysis of the results revealed that stone itself had no effect on urinary crystallizing inhibitors. Detected increased urinary levels of Mg, citrate and pyrophosphate after ESWL, compared with pre-treatment values, could be attributed to applied therapeutic procedure.

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