scholarly journals The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats

2009 ◽  
Vol 24 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Nara Macedo Botelho Brito ◽  
Rita de Kássia Vidigal Carvalho ◽  
Lia Tavares de Moura Brasil Matos ◽  
Rodolfo Costa Lobato ◽  
Rosângela Baía Brito
Keyword(s):  
Acetic Acid ◽  
Tumor Growth ◽  
Uterine Cervix ◽  
Statistical Difference ◽  
Female Rats ◽  
Tumor Mass ◽  
Tumor Group ◽  
Walker 256 ◽  
Similar Development ◽  
Walker 256 Tumor

PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.

scholarly journals The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats

2010 ◽  
Vol 25 (2) ◽  
pp. 176-180 ◽  
Author(s):  
Nara Macedo Botelho Brito ◽  
Marcus Vinicius Henriques Brito ◽  
Rita de Kássia Vidigal Carvalho ◽  
Lia Tavares de Moura Brasil Matos ◽  
Rodolfo Costa Lobato ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Tumor Growth ◽  
Uterine Cervix ◽  
Wistar Rats ◽  
Female Rats ◽  
Distilled Water ◽  
Test Results ◽  
Female Wistar Rats ◽  
Walker 256 ◽  
Inhibitory Potential

PURPOSE: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. RESULTS: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. CONCLUSION: The copaiba balsam stimulated the tumor growth.

Variability and Discontinuity of the Pathognomonic Systemic Effects Caused by Walker 256 Tumor Progression in Rats

1995 ◽  
Vol 81 (5) ◽  
pp. 370-377 ◽  
Author(s):  
Ovidio Rettori ◽  
Ana Neuza Vieira-Matos ◽  
Quivo S. Tahin
Keyword(s):  
Tumor Growth ◽  
Primary Tumor ◽  
Marked Reduction ◽  
Prognostic Indicator ◽  
Individual Variability ◽  
Systemic Effects ◽  
Primary Tumor Growth ◽  
Multifocal Tumor ◽  
Walker 256 ◽  
Walker 256 Tumor

Cancer pathognomonic systemic effects (PSE) have high individual variability. For this reason present data were collected daily and synchronized considering four main points: inoculation day, onset of PSE, aggravation and death. The subclinical period free of PSE ranged between 15.7±2.2 days, the clinical period was less variable, 8.9±0.5 days, divided in a moderate and a grave phase of nearly the same length. PSE involved disturbances of fundamental homeostatic regulations: appetite, sodium, water, immune, etc. PSE triggering correlated highly with survival (r2=0.95, P<0.01), but poorly with primary tumor growth, and it was anticipated by metastases from 20.5±2.6 to 10.6±1.1 days (P<0.01). After multifocal simultaneous inoculations, PSE triggering was anticipated to 4.2±0.2 days (marked reduction of individual variability), in the presence of small total-tumor masses, absence of macroscopic metastases, and without changes in the following clinical period features. PSE triggering seems to be a major prognostic indicator probably related to multifocal tumor growth.

α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats

2015 ◽  
Vol 67 (5) ◽  
pp. 839-846 ◽  
Author(s):  
Dalton Luiz Schiessel ◽  
Ricardo K. Yamazaki ◽  
Marcelo Kryczyk ◽  
Isabela Coelho ◽  
Adriana A. Yamaguchi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Tumor Growth ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Tumor Bearing ◽  
Walker 256 ◽  
Linolenic Fatty Acid ◽  
Walker 256 Tumor

scholarly journals Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Camila de Carvalho Juanes ◽  
Susana Moreira de Souza ◽  
Vanessa Nogueira Lages Braga ◽  
Francisco Stefânio Barreto ◽  
Gisele Rocha Aguiar ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Cells ◽  
Cheek Pouch ◽  
Hamster Cheek Pouch ◽  
New Model ◽  
Walker 256 ◽  
Walker 256 Tumor

Creatine supplementation does not promote tumor growth or enhance tumor aggressiveness in Walker-256 tumor-bearing rats

Nutrition ◽  
2020 ◽  
Vol 79-80 ◽  
pp. 110958
Author(s):  
Paola Sanches Cella ◽  
Poliana C. Marinello ◽  
Camila S. Padilha ◽  
Mayra T. Testa ◽  
Philippe B. Guirro ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Creatine Supplementation ◽  
Tumor Aggressiveness ◽  
Tumor Bearing ◽  
Promote Tumor Growth ◽  
Walker 256 ◽  
Walker 256 Tumor

scholarly journals Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA

2013 ◽  
Vol 46 (8) ◽  
pp. 696-699 ◽  
Author(s):  
G. Borghetti ◽  
R.K. Yamazaki ◽  
I. Coelho ◽  
D.C.T. Pequito ◽  
D.L. Schiessel ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Fish Oil ◽  
Growth Reduction ◽  
Tumor Bearing ◽  
Epa And Dha ◽  
Gene Level ◽  
Walker 256 ◽  
Walker 256 Tumor

scholarly journals Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Patrícia Brigatte ◽  
Odair Jorge Faiad ◽  
Roberta Cornélio Ferreira Nocelli ◽  
Richardt G. Landgraf ◽  
Mario Sergio Palma ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tumor Growth ◽  
Plasma Concentrations ◽  
Vessel Diameter ◽  
Blood Vessel Formation ◽  
Formyl Peptide Receptors ◽  
Vessel Formation ◽  
Formyl Peptide ◽  
Walker 256 ◽  
Walker 256 Tumor

We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous lipoxin A4. Treatment with CTX (s.c.), daily, for 5 days reduced tumor growth at the 5th day after injection of Walker 256 carcinoma cells into the plantar surface of adult rat hind paw. This observation was associated with inhibition of new blood vessel formation and decrease in blood vessel diameter. The treatment with CTX raised plasma concentrations of lipoxin A4and its natural analogue 15-epi-LXA4, an effect mediated by formyl peptide receptors (FPRs). In fact, the treatment with Boc-2, an inhibitor of FPRs, abolished the increase in plasma levels of these mediators triggered by CTX. The blockage of these receptors also abolished the inhibitory action of CTX on tumor growth and blood vessel formation and the decrease in blood vessel diameter. Together, the results herein presented demonstrate that CTX increases plasma concentrations of lipoxin A4and 15-epi-LXA4, which might inhibit both tumor growth and formation of new vessels via FPRs.

Cancer Cachexia and Tumor Growth Reduction in Walker 256 Tumor-Bearing Rats Supplemented With N-3 Polyunsaturated Fatty Acids for One Generation

2003 ◽  
Vol 46 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Valeria Togni ◽  
Claudia C. C. Ota ◽  
Alessandra Folador ◽  
O. Tchaikovski Junior ◽  
Julia Aikawa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Tumor Growth ◽  
Cancer Cachexia ◽  
Growth Reduction ◽  
Tumor Bearing ◽  
Walker 256 ◽  
Walker 256 Tumor

Ratio of n6 to n-3 Fatty Acids in the Diet Affects Tumor Growth and Cachexia in Walker 256 Tumor-Bearing Rats

2005 ◽  
Vol 53 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Nathalia Pizato ◽  
Sandro Bonatto ◽  
Ricardo K. Yamazaki ◽  
Julia Aikawa ◽  
Claudia Nogata ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Tumor Growth ◽  
Tumor Bearing ◽  
Walker 256 ◽  
Walker 256 Tumor
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