scholarly journals Alzheimer's patients do not show left unilateral spatial neglect but exhibit peripheral inattention and simplification

2007 ◽  
Vol 1 (4) ◽  
pp. 374-380 ◽  
Author(s):  
Mari Kasai ◽  
Junichi Ishizaki ◽  
Kenichi Meguro
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Line Bisection ◽  
Spatial Neglect ◽  
Test Results ◽  
Unilateral Spatial Neglect ◽  
Complex Figure ◽  
Figure Test ◽  
Category Score

Abstract The Rey-Osterrieth Complex Figure Test (RCFT) is widely used to measure visuoperceptual and visuoconstructional skills, while the Line Bisection (LB) test is commonly employed to assess unilateral spatial neglect (USN). Previous studies have suggested that Alzheimer's disease (AD) patients may suffer from left USN. Objectives: The purpose of this study was to clarify whether left USN occurs in AD. Methods: Forty controls, 40 very mild AD patients and 31 mild/moderate AD patients performed both the RCFT copying and the LB test. Results: The very mild AD and mild/moderate AD groups had lower total RCFT copying scores and also scored lower in the "left" and "detail" categories compared to controls. However, there were no correlations between the left-category score for RCFT and the LB score. Instead, peripheral inattention and simplification patterns were noted. Conclusions: We found that the RCFT copying test is effective for detecting early AD and suggest that AD patients manifest peripheral inattention and simplification but not left USN.

Unilateral Spatial Neglect in The Late Stage of Alzheimer's Disease

Cortex ◽  
1998 ◽  
Vol 34 (5) ◽  
pp. 743-752 ◽  
Author(s):  
Annalena Venneri ◽  
Roberta Pentore ◽  
Biagio Cotticelli ◽  
Sergio Della Sala
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Stage ◽  
Spatial Neglect ◽  
Unilateral Spatial Neglect

Influence of Colour Lightness Differences in Patients With Left Unilateral Spatial Neglect

2010 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Shinsuke Sato ◽  
Akio Tsubahara ◽  
Yoichiro Aoyagi ◽  
Takashi Hiraoka ◽  
Sumire Hasegawa ◽  
...  
Keyword(s):  
Japanese Version ◽  
Line Bisection ◽  
Spatial Neglect ◽  
Unilateral Spatial Neglect ◽  
Laterality Index ◽  
Green Background

AbstractWe used desk-based tasks to evaluate and clarify the effects of colour lightness differences (Liebmann effect) in patients with left unilateral spatial neglect (USN) following stroke. Participants were 30 adults with USN (16 men and 14 women; mean age = 72.3 years, SD = 8.9 years). They took the ‘Letter Cancellation Test’ of the Japanese version of the Behavioral Inattention Test using two types of paper: black letters with a yellow background (‘black on yellow’) and red letters with a green background (‘red on green’). They also took the Line Bisection Test and their laterality index (LI) was also determined. Paired t-tests were computed comparing the LI by colour displays. LI was higher for ‘black on yellow’ than for ‘red on green’ in patients with mild left USN. However, LI for ‘red on green’ was higher in patients with severe left USN. Colour lightness differences are likely on the left side in patients with relatively mild left USN, but not in those with severe left USN.

Research on Computer-Aided Diagnosis of Alzheimer’s Disease Based on Heterogeneous Medical Data Fusion

2019 ◽  
Vol 33 (05) ◽  
pp. 1957001
Author(s):  
Yin Dai ◽  
Daoyun Qiu ◽  
Yang Wang ◽  
Sizhe Dong ◽  
Hong-Li Wang
Keyword(s):  
Neural Network ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Convolutional Neural Network ◽  
Effective Means ◽  
Computer Aided Diagnosis ◽  
Test Results ◽  
Back Propagation Algorithm ◽  
Computer Aided ◽  
Aided Diagnosis

Alzheimer’s disease is the third most expensive disease, only after cancer and cardiopathy. It is also the fourth leading cause of death in the elderly after cardiopathy, cancer, and cerebral palsy. The disease lacks specific diagnostic criteria. At present, there is still no definitive and effective means for preclinical diagnosis and treatment. It is the only disease that cannot be prevented and cured among the world’s top ten fatal diseases. It has now been proposed as a global issue. Computer-aided diagnosis of Alzheimer’s disease (AD) is mostly based on images at this stage. This project uses multi-modality imaging MRI/PET combining with clinical scales and uses deep learning-based computer-aided diagnosis to treat AD, improves the comprehensiveness and accuracy of diagnosis. The project uses Bayesian model and convolutional neural network to train experimental data. The experiment uses the improved existing network model, LeNet-5, to design and build a 10-layer convolutional neural network. The network uses a back-propagation algorithm based on a gradient descent strategy to achieve good diagnostic results. Through the calculation of sensitivity, specificity and accuracy, the test results were evaluated, good test results were obtained.

scholarly journals Planning ability impairments in probable Alzheimer's disease patients: Evidence from the Tower of London test

2017 ◽  
Vol 11 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Corina Satler ◽  
Luiza Guimarães ◽  
Carlos Tomaz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Abilities ◽  
Poor Performance ◽  
Test Results ◽  
Tower Of London ◽  
Inappropriate Behaviors ◽  
Inhibitory Deficits ◽  
Planning Ability ◽  
Wide Range

ABSTRACT Alzheimer's disease (AD) is associated with progressive impairment of higher-level cognitive abilities. Previous research suggests that early impairment of executive functions occurs during the course of the disease, but few studies have specifically investigated planning ability in an AD population. Objective: The purpose of the current study was to examine whether AD patients retain the ability to plan ahead, by analyzing specificities of their behavior in successfully achieving a pre-established goal. Methods: Twenty-one AD patients and thirty-three elderly controls underwent a problem-solving assessment using the Tower of London (TOL) test. Results: AD patients were less accurate and less efficient than controls. AD patients also committed more mistakes. This indicates a decline in working memory and inhibitory deficits, resulting in impulsive and inappropriate behaviors. Conclusion: These results are in agreement with previous studies, showing executive function problems in patients with AD. Specifically, this study demonstrates the presence of planning ability deficits in AD, considering both qualitative and quantitative approaches. The wide range of analysis presented in this study can aid clinicians in identifying the nature of the poor performance of AD patients during a planning task.

Clinical and Functional Assessment of Dysautonomia and Its Correlation in Alzheimer’s Disease

2012 ◽  
Vol 27 (8) ◽  
pp. 592-599 ◽  
Author(s):  
Beata Zakrzewska-Pniewska ◽  
Malgorzata Gawel ◽  
Elzbieta Szmidt-Salkowska ◽  
Katarzyna Kepczynska ◽  
Monika Nojszewska
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Urinary Incontinence ◽  
Orthostatic Hypotension ◽  
Functional Assessment ◽  
Sympathetic Skin Response ◽  
Test Results ◽  
Significant Difference ◽  
Skin Response ◽  
The Relationship

The aims were to assess dysautonomia in Alzheimer’s Disease (AD), clinically and electrophysiologically, using sympathetic skin response (SSR) test and R-R interval variation (RRIV) test and to analyze the relationship between symptoms of dysautonomia and SSR/RRIV results. A tota of 54 patients with AD and 37 controls were evaluated using Autonomic Symptoms Questionnaire and SSR/RRIV test. Clinical dysautonomia was observed in 66% of patients (eg, orthostatic hypotension in 34.5%, constipation in 17.2%, urinary incontinence in 13.8%). The SSR test was abnormal in 26%, but the RRIV test was abnormal in 97.7% of cases; there was significant difference in RRIV test results between AD and controls (R mean 8.05% and 14.6%, respectively). In AD, clinical dysautonomia occurs at a various degree, and the abnormal SSR and RRIV test results were not always related to the presence of clinical dysautonomia; this observation points that the tests could be used as a useful tool in the assessment of subclinical dysautonomia.

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