P2-364 The Rey-Osterrieth Complex Figure Test copying, immediate and delayed reproduction for very mild Alzheimer's disease: the Tajiri project (6)

2004 ◽  
Vol 25 ◽  
pp. S337
Author(s):  
Mari Sato ◽  
Kenichi Meguro ◽  
Ryusaku Hashimoto ◽  
Atsushi Yamadori ◽  
Yasuyoshi Sekita
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Complex Figure ◽  
Delayed Reproduction ◽  
Figure Test

scholarly journals Alzheimer's patients do not show left unilateral spatial neglect but exhibit peripheral inattention and simplification

2007 ◽  
Vol 1 (4) ◽  
pp. 374-380 ◽  
Author(s):  
Mari Kasai ◽  
Junichi Ishizaki ◽  
Kenichi Meguro
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Line Bisection ◽  
Spatial Neglect ◽  
Test Results ◽  
Unilateral Spatial Neglect ◽  
Complex Figure ◽  
Figure Test ◽  
Category Score

Abstract The Rey-Osterrieth Complex Figure Test (RCFT) is widely used to measure visuoperceptual and visuoconstructional skills, while the Line Bisection (LB) test is commonly employed to assess unilateral spatial neglect (USN). Previous studies have suggested that Alzheimer's disease (AD) patients may suffer from left USN. Objectives: The purpose of this study was to clarify whether left USN occurs in AD. Methods: Forty controls, 40 very mild AD patients and 31 mild/moderate AD patients performed both the RCFT copying and the LB test. Results: The very mild AD and mild/moderate AD groups had lower total RCFT copying scores and also scored lower in the "left" and "detail" categories compared to controls. However, there were no correlations between the left-category score for RCFT and the LB score. Instead, peripheral inattention and simplification patterns were noted. Conclusions: We found that the RCFT copying test is effective for detecting early AD and suggest that AD patients manifest peripheral inattention and simplification but not left USN.

scholarly journals Working Memory Decline in Alzheimer’s Disease Is Detected by Complexity Analysis of Multimodal EEG-fNIRS

Entropy ◽  
2020 ◽  
Vol 22 (12) ◽  
pp. 1380
Author(s):  
David Perpetuini ◽  
Antonio Maria Chiarelli ◽  
Chiara Filippini ◽  
Daniela Cardone ◽  
Pierpaolo Croce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Near Infrared ◽  
Complexity Analysis ◽  
Brain Activity ◽  
Conditional Entropy ◽  
Functional Near Infrared Spectroscopy ◽  
Complex Figure ◽  
Raven's Progressive Matrices

Alzheimer’s disease (AD) is characterized by working memory (WM) failures that can be assessed at early stages through administering clinical tests. Ecological neuroimaging, such as Electroencephalography (EEG) and functional Near Infrared Spectroscopy (fNIRS), may be employed during these tests to support AD early diagnosis within clinical settings. Multimodal EEG-fNIRS could measure brain activity along with neurovascular coupling (NC) and detect their modifications associated with AD. Data analysis procedures based on signal complexity are suitable to estimate electrical and hemodynamic brain activity or their mutual information (NC) during non-structured experimental paradigms. In this study, sample entropy of whole-head EEG and frontal/prefrontal cortex fNIRS was evaluated to assess brain activity in early AD and healthy controls (HC) during WM tasks (i.e., Rey–Osterrieth complex figure and Raven’s progressive matrices). Moreover, conditional entropy between EEG and fNIRS was evaluated as indicative of NC. The findings demonstrated the capability of complexity analysis of multimodal EEG-fNIRS to detect WM decline in AD. Furthermore, a multivariate data-driven analysis, performed on these entropy metrics and based on the General Linear Model, allowed classifying AD and HC with an AUC up to 0.88. EEG-fNIRS may represent a powerful tool for the clinical evaluation of WM decline in early AD.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Formation of paired helical filaments in Alzheimer's disease

1984 ◽  
Vol 42 ◽  
pp. 302-303
Author(s):  
J. Metuzals ◽  
D. F. Clapin ◽  
V. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Normal Brain ◽  
Protein Assemblies ◽  
Electron Microscopic ◽  
Helical Symmetry ◽  
Structural Levels

Information on the conformation of paired helical filaments (PHF) and the neurofilamentous (NF) network is essential for an understanding of the mechanisms involved in the formation of the primary lesions of Alzheimer's disease (AD): tangles and plaques. The structural and chemical relationships between the NF and the PHF have to be clarified in order to discover the etiological factors of this disease. We are investigating by stereo electron microscopic and biochemical techniques frontal lobe biopsies from patients with AD and squid giant axon preparations. The helical nature of the lesion in AD is related to pathological alterations of basic properties of the nervous system due to the helical symmetry that exists at all hierarchic structural levels in the normal brain. Because of this helical symmetry of NF protein assemblies and PHF, the employment of structure reconstruction techniques to determine the conformation, particularly the handedness of these structures, is most promising. Figs. 1-3 are frontal lobe biopsies.

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