scholarly journals Peripheral biomarkers of oxidative stress in aging and Alzheimer's disease

2008 ◽  
Vol 2 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Tania Marcourakis ◽  
Rosana Camarini ◽  
Elisa Mitiko Kawamoto ◽  
Leandro Rodrigues Scorsi ◽  
Cristoforo Scavone
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
The Central Nervous System ◽  
Peripheral Markers ◽  
Lateral Sclerosis ◽  
Biomarkers Of Oxidative Stress

Abstract Aging is associated with a greatly increased incidence of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). These conditions are associated with chronic inflammation, which generates oxygen reactive species, ultimately responsible for a process known as oxidative stress. It is well established that this process is the culprit of neurodegeneration, and there are also mounting evidences that it is not restricted to the central nervous system. Indeed, several studies, including some by our group, have demonstrated that increased peripheral oxidative stress markers are associated to aging and, more specifically, to AD. Therefore, it is very instigating to regard aging and AD as systemic conditions that might be determined by studying peripheral markers of oxidative stress.

scholarly journals The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Ya-Ting Chang ◽  
Wen-Neng Chang ◽  
Nai-Wen Tsai ◽  
Chih-Cheng Huang ◽  
Chia-Te Kung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Web Of Science ◽  
Elevated Serum ◽  
Serum Markers ◽  
Sufficient Evidence ◽  
Markers Of Oxidative Stress ◽  
Biomarkers Of Oxidative Stress

Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies.Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD.Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

Oxidative Stress Markers and Metal Ions are Correlated With Cognitive Function in Alzheimer’s Disease

2017 ◽  
Vol 32 (6) ◽  
pp. 353-359 ◽  
Author(s):  
Zhengping Pu ◽  
Wenjie Xu ◽  
Yong Lin ◽  
Jincai He ◽  
Manli Huang
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Ions ◽  
Serum Levels ◽  
Zinc Level ◽  
Copper Level ◽  
Iron Level ◽  
Oxidative Stress Markers ◽  
Stress Markers

We investigated oxidative stress markers and metal ions in patients with Alzheimer’s disease (AD). The serum levels of ceruloplasmin (CER), C-reactive protein (CRP), uric acid (UA), homocysteine (Hcy), copper, iron, and zinc were determined in 125 patients with AD (mild, n = 2 8; moderate, n = 42; and severe, n = 55) and 40 healthy control (HC) participants. Compared to HC, CER and UA levels were significantly lower in moderate and severe AD groups, whereas CRP and Hcy levels were significantly higher in the severe AD group. Copper level was significantly higher in moderate and severe AD groups than the other groups. Compared to HC, iron level was significantly higher in patients with AD, whereas zinc level was significantly lower in patients with AD. In patients with AD, the severity of cognitive impairment was positively correlated with CER, UA, and zinc levels, whereas it was negatively correlated with copper level. Taken together, our findings provide a novel approach to assess AD progression.

scholarly journals Biothiols and oxidative stress markers and polymorphisms of TOMM40 and APOC1 genes in Alzheimer’s disease patients

Oncotarget ◽  
2018 ◽  
Vol 9 (81) ◽  
pp. 35207-35225 ◽  
Author(s):  
Michal Prendecki ◽  
Jolanta Florczak-Wyspianska ◽  
Marta Kowalska ◽  
Jan Ilkowski ◽  
Teresa Grzelak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

Ischemia Modified Albumin and Plasma Oxidative Stress Markers in Alzheimer's Disease

2013 ◽  
Vol 69 (6) ◽  
pp. 377-380 ◽  
Author(s):  
Murat Can ◽  
Figen Varlibas ◽  
Berrak Guven ◽  
Ozkan Akhan ◽  
Gulbun Asuman Yuksel
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Stress Markers ◽  
Ischemia Modified Albumin ◽  
Stress Markers

Peripheral Oxidative Stress Markers in Individuals with Alzheimer's Disease with or without Cerebrovascular Disease

2015 ◽  
Vol 63 (7) ◽  
pp. 1472-1474 ◽  
Author(s):  
Hirokuni Hatanaka ◽  
Haruo Hanyu ◽  
Daisuke Hirose ◽  
Raita Fukusawa ◽  
Nayuta Namioka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Oxidative Stress Markers ◽  
Stress Markers

Oxidative Stress Markers of Alzheimer's Disease in Peripheral Cell Mitochondria

2017 ◽  
Vol 108 ◽  
pp. S100 ◽  
Author(s):  
Christian Schoneich ◽  
Asha Hewarathna ◽  
Ranu Pal ◽  
Lei Jiang ◽  
Elias Michaelis
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Stress Markers ◽  
Peripheral Cell ◽  
Stress Markers

scholarly journals γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer’s Disease-like Pathology and Neurodegeneration in a Mouse Model

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1796
Author(s):  
Ye In Christopher Kwon ◽  
Wei Xie ◽  
Haizhou Zhu ◽  
Jiashu Xie ◽  
Keaton Shinn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Deficits ◽  
Brain Inflammation ◽  
Stress Markers ◽  
Early Memory ◽  
Glutamyl Transpeptidase

Oxidative stress in Alzheimer’s disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stress markers in brains of APP/PS1 transgenic mice, a mouse model of AD, and attenuates early memory deficits in the APP/PS1 model. Herein, we examined whether Ψ-GSH can attenuate the disease progression when administered following the onset of AD-like pathology in vivo. Cohorts of APP/PS1 mice were administered Ψ-GSH for 2 months starting at 8 month or 12 months of age. We show that Ψ-GSH treatment reduces indices of oxidative stress in older mice by restoration of enzyme glyoxalase-1 (Glo-1) activity and reduces levels of insoluble Aβ. Quantitative neuropathological analyses show that Ψ-GSH treatment significantly reduces Aβ deposition and brain inflammation in APP/PS1 mice compared to vehicle-treated mice. More importantly, Ψ-GSH treatment attenuated the progressive loss of cortical TH+ afferents and the loss of TH+ neurons in the locus coeruleus (LC). Collectively, the results show that Ψ-GSH exhibits significant antioxidant activity in aged APP/PS1 mice and chronic Ψ-GSH treatment administered after the onset of AD pathology can reverse/slow further progression of AD-like pathology and neurodegeneration in vivo.

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