Sodium alginate-guar gum and carbopol based methotrexate loaded mucoadhesive microparticles for colon delivery: An in vitro evaluation

2021 ◽  
Vol 57 ◽  
Author(s):  
Rohitas Deshmukh ◽  
Ranjit K Harwansh ◽  
Md. Akhlaquer Rahman
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
In Vitro Evaluation ◽  
Colon Delivery

Advancement Of Changed Pulsincap Medicate Conveyance Arrangement Of Metronidazole For Tranquilize Focusing

2020 ◽  
Vol 2 (05) ◽  
pp. I-IV
Author(s):  
Roshni Jha ◽  
Anjali Minj
Keyword(s):  
Acetic Acid ◽  
Sodium Alginate ◽  
Guar Gum

A changed Pulsincap measurements type of metronidazole was created to target tranquilize discharge in the colon. Groups of hard gelatin cases were treated with formaldehyde keeping the tops in that capacity. Metronidazole pellets arranged by expulsion spheronization technique were consolidated into these particular container shells and stopped with polymers guar gum, hydroxypropylmethylcellulose 10K, carboxymethylcellulose sodium and sodium alginate independently at fixations 20 mg, 30 mg and 40 mg. The filled cases were totally covered with 5% cellulose acetic acid derivation phthalate to forestall variable gastric purging. All the definitions were tested to decide sedate substance and the capacity of the adjusted Pulsincap to give colon-explicit medication conveyance was surveyed by in vitro tranquilize discharge concentrates in cushion pH 1.2 for 2 h, pH 7.4 (reproduced intestinal liquid) for 3 h and pH 6.8 (animated colonic liquid) for 7 h. The outcomes showed that critical medication discharge happened simply after 5 h from the beginning of analysis.

scholarly journals Oily in situ gels as an alternative floating platform for ketoconazole release

2020 ◽  
Vol 11 (2) ◽  
pp. 2638-2649
Author(s):  
Masar Basim Mohsin Mohamed ◽  
Iman Sabah Jaafar ◽  
Methaq Hamad Sabar ◽  
Marwa Hazem Jasim ◽  
Furqan M. Abdulelah ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
In Vitro Release ◽  
Medium Chain Triglyceride ◽  
Floating Platform ◽  
Release Study ◽  
Model Drug

Sodium alginate, calcium carbonate, and guar gum were mixed with oils such as olive oil (OO), sesame oil (SO), and medium chain triglyceride (MCT). The oily formulations were found to simplify the preparation of in situ floating gel. This was the aim of this study using ketoconazole (keto) as a model drug. The investigations for the floating property were established by In vitro gelling capacity study and In vitro floating study. Additionally, in vitro release study was applied to find the best formulations to delay the release of keto. Then, selected formulations were studied by FTIR and SEM. Lastly, in vivo gelation was performed to examine the gelation in the rat’s stomach. The results showed all formulations were floating after successful gelation as the least amount of sodium alginate to gel oils was 20% w/w. The gels in SO and OO were better than MCT in delaying keto release, and 30% w/w sodium alginate in SO was the best to delay the release of keto within 8 hours of the release study. Selected gels showed interactions between the keto molecules and the molecules of the gel contents by FTIR study, and SEM showed a difference in the internal structure of selected formulations. Lastly, the 30% w/w sodium alginate in SO proved to gel and remain in the rat's stomach in the following periods: 30 min, 1 hour, 2 hours, and after 8 hours. Oily suspension formulations showed floating properties in the stomach and slowed the release of keto and specifically 30% w/w of sodium alginate in SO.

In vitro evaluation of guar gum as a carrier for colon-specific drug delivery

1998 ◽  
Vol 51 (2-3) ◽  
pp. 281-287 ◽  
Author(s):  
Y.V.Rama Prasad ◽  
Y.S.R Krishnaiah ◽  
S Satyanarayana
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Specific Drug ◽  
In Vitro Evaluation ◽  
Colon Specific Drug Delivery

PREPARATION AND IN VITRO EVALUATION OF BIODEGRADABLE ZIDOVUDINE LOADED CONTROLLED RELEASE MICROSPHERES USING NATURAL GUMS AS RELEASE RETARDANTS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (06) ◽  
pp. 37-45
Author(s):  
S. M. Sai ◽  
◽  
R. P Swain ◽  
A. K Mahapatra
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
Particle Diameter ◽  
Kinetic Studies ◽  
Entrapment Efficiency ◽  
Processing Parameters ◽  
In Vitro Drug Release ◽  
Percentage Yield ◽  
Drug Entrapment Efficiency

The objective of the present investigation was to evaluate the entrapment efficiency of the anti-HIV drug, zidovudine, using natural gums and study the zidovudine release. Zidovudine-loaded microspheres were prepared by external ionotropic gelation technique. Sodium alginate in combination with guar gum or xanthan gums in different ratios were used. The microspheres of different core: coat ratios were formulated and evaluated for entrapment efficiency, particle size, percentage yield, swelling index, in vitro drug release and kinetic studies. Drug polymer compatibility studies were performed by Fourier Transform Infrared (FTIR) spectroscopy. The formulation was characterized by X-ray powder diffraction (XRD) and scanning electron Microscope (SEM). The zidovudine loaded microspheres have a particle diameter ranging approximately 450-779 μm. The FTIR showed compatibility between drug and excipients. Processing parameters (stirring speed, concentration of cross linking agent, volume of the processing medium on drug entrapment efficiency were optimized. F20 (1 g of sodium alginate and 0.150 g of guar gum) and F13 (1 g of sodium alginate, 0.250 g of xanthan gum) formulations showed better release (ANOVA, ˂0.05) profiles over a period of 12 h. Natural gums are biodegradable, safe, non-toxic and are used as release retardants and these can be extended to prepare microspheres of other drugs.

The in vitro evaluation of ‘azo containing polysaccharide gels’ for colon delivery

2001 ◽  
Vol 75 (1-2) ◽  
pp. 103-114 ◽  
Author(s):  
Barbara Stubbe ◽  
Bart Maris ◽  
Guy Van den Mooter ◽  
Stefaan C De Smedt ◽  
Joseph Demeester
Keyword(s):  
In Vitro Evaluation ◽  
Colon Delivery

scholarly journals TRANSDERMAL DELIVERY OF AN EFFECTIVE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS FOR PAIN MANAGEMENT IN ARTHRITIS

2020 ◽  
pp. 41-47
Author(s):  
MANJULA D ◽  
ABHISHEK RAJ ◽  
JOSEPHINE LENO JENITA J ◽  
SHANAZ BANU
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Guar Gum ◽  
Research Work ◽  
Albino Rats ◽  
Drug Content ◽  
In Vitro Permeation ◽  
Permeation Studies ◽  
Anti Inflammatory

Objective: The current research work has been carried out with the aim to develop a transdermal gel formulation of fenoprofen (a nonsteroidal anti-inflammatory drug used to treat pain associated in arthritis) which would overcome the gastrointestinal-related problems associated with oral administration of the drug. The present study aims at formulating transdermal gels using different concentrations of Carbopol, hydroxypropyl methylcellulose (HPMC), sodium alginate, and guar gum. Methods: The formulated gels were subjected for various evaluation tests such as clarity, homogeneity, viscosity, drug content, pH, spreadability, and in vitro permeation studies. Drug–polymer interaction was studied by Fourier transmission infrared (FTIR) and differential scanning calorimetry (DSC). The in vitro permeation studies were performed in phosphate buffer 7.4 using Franz diffusion cell. Results: The FT-IR and DSC studies showed no chemical interaction between drug and polymers used. All the formulated gels showed acceptable physical properties with respect to clarity, homogeneity, viscosity, drug content, pH, and spreadability. Among all the gel formulations, Carbopol gels containing fenoprofen showed good drug release compared to HPMC, sodium alginate, and guar gum. Optimized formulation was further subjected to kinetic studies which showed Higuchi model of drug release. The same formulation showed significant anti-inflammatory and analgesic activity, tested in Wistar albino rats. No signs of erythema, edema, flushing, and papules were observed when skin irritation test was performed. Stability studies under accelerated condition showed satisfactory results for the optimized formulation. Conclusions: Thus, it was concluded from the results that the optimized formulation showed controlled and slow drug delivery. Animal studies were significant at p<0.05 and 0.001. The selected formulation was stable at various ambient temperatures.

Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films

2014 ◽  
Vol 3 (3) ◽  
pp. 243-246 ◽  
Author(s):  
P.K. Lakshmi ◽  
D. Lavanya ◽  
M.M. Husnien Ali
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
Pharmaceutical Journal ◽  
In Vitro Dissolution ◽  
Poly Vinyl Alcohol ◽  
Natural Polymers ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Donepezil Hydrochloride

The main aim of the present research was to develop a fast dissolving oral polymeric film with good mechanical properties, faster disintegration and dissolution when placed on tongue. Donepezil hydrochloride (DPH) is prescribed in the treatment of mild to moderate Alzheimer’s disease (AD). The polymers selected for preparing films were sodium alginate (SA), poly vinyl alcohol (PVA) and guar gum (GG). Three batches of films were prepared by solvent casting method with sodium alginate, sodium alginate & PVA and with the combination of sodium alginate & guar gum. From these three batches, three optimized film formulations S3, SP7 and SG8 were selected based on disintegration time. To these three selected film formulations, superdisintegrants sodium starch glycolate (SSG), cross carmellose sodium (CCS) and cross povidone (CP) were added at a concentration of 4% w/w of polymer to improve the disintegration time. The films prepared with or without superdisintegrants were compared for fast releasing properties. Based on DT and in vitro dissolution data, S3CP was selected as the best formulation among the all formulations.DOI: http://dx.doi.org/10.3329/icpj.v3i3.17892 International Current Pharmaceutical Journal, February 2014, 3(3): 243-246

Sodium Alginate Microspheres of Metformin HCl: Formulation and In Vitro Evaluation

2007 ◽  
Vol 4 (3) ◽  
pp. 249-256 ◽  
Author(s):  
J. Balasubramaniam ◽  
Vinay U. Rao ◽  
M. Vasudha ◽  
Jeevan Babu ◽  
P.S. Rajinikanth
Keyword(s):  
Sodium Alginate ◽  
In Vitro Evaluation ◽  
Metformin Hcl
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