Involvement of G2/M Cell Cycle Arrest and the Mitochondrial Pathway in Boletopsis leucomelaena (Pers.) Fayod (Agaricomycetideae) Lectin-Induced Apoptosis of Human Leukemia U937 Cells

2005 ◽  
Vol 7 (1-2) ◽  
pp. 201-212 ◽  
Author(s):  
Yu Koyama ◽  
Takuji Suzuki ◽  
Akane Kajiya ◽  
Mamoru Isemura
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Mitochondrial Pathway ◽  
Human Leukemia ◽  
U937 Cells ◽  
M Cell ◽  
Cycle Arrest ◽  
Induced Apoptosis

scholarly journals β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

2014 ◽  
Vol 6 ◽  
pp. 290-304 ◽  
Author(s):  
Suvitha Syam ◽  
Ahmad Bustamam ◽  
Rasedee Abdullah ◽  
Mohamed Aspollah Sukari ◽  
Najihah Mohd Hashim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Mitochondrial Pathway ◽  
M Cell ◽  
Cycle Arrest ◽  
Mcf 7

scholarly journals Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

2019 ◽  
Vol 69 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Affidah Sabran ◽  
Endang Kumolosasi ◽  
Ibrahim Jantan
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Leukemic Cell ◽  
Jurkat Cells ◽  
G1 Phase ◽  
U937 Cells ◽  
Annexin A1 ◽  
Leukemic Cell Lines ◽  
Cycle Arrest ◽  
Induced Apoptosis

Abstract Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC). Cells were treated with ANXA1 and cyclophosphamide prior to flow cytometry analysis for apoptosis and cell cycle arrest induction. At 2.5µM, ANXA1 induced significant apoptosis in K562 (p ≤ 0.001) and U937 (p ≤ 0.05) cells, with EC50 values of 3.6 and 3.8 µM, respectively. In Jurkat cells, induction was not significant (EC50, 17.0 µM). No significant apoptosis induction was observed in PBMC. ANXA1 caused cycle arrest in the G0/G1 phase in K562 and U937 cells with p ≤ 0.001 for both, and (p ≤ 0.01) for Jurkat cells. ANXA1 induced apoptosis and cycle arrest in the G0/G1 phase in K562 and U937 cells, causing only cell cycle arrest in Jurkat cells.

Retraction: A Dihydrobenzofuran Lignan Induces Cell Death by Modulating Mitochondrial Pathway and G2/M Cell Cycle Arrest

2013 ◽  
Vol 56 (4) ◽  
pp. 1787-1787
Author(s):  
Julie S. Bose ◽  
Vijay Gangan ◽  
Ravi Prakash ◽  
Swatantra Kumar Jain ◽  
Sunil Kumar Manna
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Mitochondrial Pathway ◽  
M Cell ◽  
Cycle Arrest

scholarly journals Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69103 ◽  
Author(s):  
Chandagirikoppal V. Kavitha ◽  
Mridula Nambiar ◽  
Pavan B. Narayanaswamy ◽  
Elizabeth Thomas ◽  
Ujjwal Rathore ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Mitochondrial Pathway ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Cycle Arrest ◽  
Human Leukemia Cells

A Dihydrobenzofuran Lignan Induces Cell Death by Modulating Mitochondrial Pathway and G2/M Cell Cycle Arrest

2009 ◽  
Vol 52 (10) ◽  
pp. 3184-3190 ◽  
Author(s):  
Julie S. Bose ◽  
Vijay Gangan ◽  
Ravi Prakash ◽  
Swatantra Kumar Jain ◽  
Sunil Kumar Manna
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Mitochondrial Pathway ◽  
M Cell ◽  
Cycle Arrest

scholarly journals Inhibition of c-Jun-N-terminal-Kinase Sensitizes Tumor Cells to CD95-Induced Apoptosis and Induces G2/M Cell Cycle Arrest

2005 ◽  
Vol 65 (15) ◽  
pp. 6780-6788 ◽  
Author(s):  
Christian Kuntzen ◽  
Nilüfer Sonuc ◽  
Enrico N. De Toni ◽  
Christine Opelz ◽  
Simon R. Mucha ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Tumor Cells ◽  
M Cell ◽  
Cycle Arrest ◽  
Induced Apoptosis

5-(2-Carboxyethenyl) isatin derivative induces G2/M cell cycle arrest and apoptosis in human leukemia K562 cells

2014 ◽  
Vol 450 (4) ◽  
pp. 1650-1655 ◽  
Author(s):  
Yao Zhou ◽  
Hong-Ye Zhao ◽  
Kai-Lin Han ◽  
Yao Yang ◽  
Bin-Bin Song ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
K562 Cells ◽  
Human Leukemia ◽  
M Cell ◽  
Cycle Arrest ◽  
Human Leukemia K562 Cells ◽  
Isatin Derivative

scholarly journals New Diterpenoids from Mesona procumbens with Antiproliferative Activities Modulate Cell Cycle Arrest and Apoptosis in Human Leukemia Cancer Cells

2021 ◽  
Vol 14 (11) ◽  
pp. 1108
Author(s):  
Hung-Tse Huang ◽  
Chia-Ching Liaw ◽  
Yu-Chi Lin ◽  
Geng-You Liao ◽  
Chih-Hua Chao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Ros Generation ◽  
Human Leukemia ◽  
Dependent Manner ◽  
U937 Cells ◽  
Cycle Arrest ◽  
Antiproliferative Activities

Mesona procumbens is a popular material used in foods and herbal medicines in Asia for clearing heat and resolving toxins. However, phytochemical research on this plant is very rare. In this study, eleven new diterpenoids, mesonols A-K (1–11), comprising seven ent-kauranes, three ent-atisanes, and one sarcopetalane, were isolated from its methanolic extract. Structural elucidation of compounds 1–11 was performed by spectroscopic methods, especially 2D NMR, HRESIMS, and X-ray crystallographic analysis. All isolates were assessed for their antiproliferative activity, and compounds 1-4 showed potential antiproliferative activities against A549, Hep-3B, PC-3, HT29, and U937 cancer cells, with IC50 values ranging from 1.97 to 19.86 µM. The most active compounds, 1 and 2, were selected for further investigation of their effects on cell cycle progression, apoptosis, and ROS generation in U937 human leukemia cancer cells. Interestingly, it was found that compounds 1 and 2 induced antiproliferative effects in U937 cells through different mechanisms. Compound 1 caused cell cycle arrest at the G2/M phase and subsequent cell death in a dose- and time-dependent manner. However, 2-mediated antiproliferation of U937 cells triggered ROS-mediated mitochondrial-dependent apoptosis. These results provide insight into the molecular mechanism involved in the antiproliferative activities of compounds 1 and 2 in U937 cells. Altogether, the study showed that new diterpenoid compounds 1 and 2 from M. procumbens are potent and promising anticancer agents.

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