Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes)

Ganoderma lucidum (Leyss.:Fr.) Karst is one of the medicinal mushrooms, which possesses enviable antioxidant properties. Objective of this investigation was to evaluate antioxidant activity, reducing power, scavenging abilities on 1.1-diphenyl-2-picrylhydrazyl (DPPH) radicals and chelating effects on ferrous ions of hot water extracts obtained from carpophore and spores of this mushroom. Hot water extract from carpophore (Gl-I) showed high antioxidant activity of 85.7 ? 0.7%, at 10 mg/ml, while antioxidant activity of hot water extract from spores (Gl-Is) was 9.2 ? 0.3% at 10 mg/ml. Reducing power of Gl-I reached a plateau of 3.4 ? 0.1 at 20 mg/ml, and 0.3 ? 0.0 at 20 mg/ml for Gl-Is. At 10 mg/ml, scavenging ability on DPPH radicals of Gl-I increased to 96.8 ? 2.5%, whereas Gl-Is scavenged DPPH radicals by 69.6 ? 2.5% at 10 mg/ml. Gl-I chelated 81.6 ? 3.6 % of ferrous ions at 20 mg/ml, while the chelating effect of Gl-Is was 73.8 ? 1.7%. The antioxidative activities of hot water extracts from carpophore and spores of the mushroom G. lucidum were concentration dependent and increased with an increase in the concentration.

Download Full-text

Ganoderma lucidum — A Leader of Medicinal Mushrooms

Mushrooms ◽

10.1201/9780203492086.ch19 ◽

2004 ◽

pp. 357-372 ◽

Cited By ~ 2

Keyword(s):

Ganoderma Lucidum ◽

Medicinal Mushrooms

Download Full-text

Cultivation of Medicinal Mushrooms Ganoderma lucidum and Grifola frondosa Mycelia and Polysaccharides in Bioreactors

Third International Conference on Advances in Applied Science and Environmental Engineering - ASEE 2015 ◽

10.15224/978-1-63248-055-2-03 ◽

2015 ◽

Author(s):

ANDREJ GREGORI ◽

BOJANA BOH ◽

BRANKA WRABER ◽

JOZI HABIJANIC ◽

MARIN BEROVIC ◽

...

Keyword(s):

Ganoderma Lucidum ◽

Grifola Frondosa ◽

Medicinal Mushrooms

Download Full-text

Pilot-scale bioconversion of rice and sunflower agro-residues into medicinal mushrooms and laccase enzymes through solid-state fermentation with Ganoderma lucidum

Bioresource Technology ◽

10.1016/j.biortech.2017.01.064 ◽

2017 ◽

Vol 231 ◽

pp. 85-93 ◽

Cited By ~ 25

Author(s):

P.D. Postemsky ◽

M.A. Bidegain ◽

R. González-Matute ◽

N.D. Figlas ◽

M.A. Cubitto

Keyword(s):

Solid State ◽

Solid State Fermentation ◽

Ganoderma Lucidum ◽

Pilot Scale ◽

Medicinal Mushrooms ◽

Agro Residues

Download Full-text

Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats

Medicines ◽

10.3390/medicines5030078 ◽

2018 ◽

Vol 5 (3) ◽

pp. 78 ◽

Cited By ~ 6

Author(s):

Erna Bach ◽

Edgar Hi ◽

Ana Martins ◽

Paloma Nascimento ◽

Nilsa Wadt

Keyword(s):

Ganoderma Lucidum ◽

Biochemical Analysis ◽

Food Supplement ◽

Diabetic Rats ◽

Diabetic Group ◽

Control Group ◽

Histopathological Analysis ◽

Beta Glucan ◽

Male Wistar Rats ◽

Normoglycemic Control

Background:Ganoderma lucidum (Leyss. Ex. Fr) Karst is a basidiomycete mushroom that has been used for many years as a food supplement and medicine. In Brazil, National Health Surveillance Agency (ANVISA) classified Ganoderma lucidum as a nutraceutical product. The objective of the present work was to observe the effects of an extract from Ganoderma lucidum in rats treated with streptozotocin, and an agent that induces diabetes. Method: Male Wistar rats were obtained from the animal lodging facilities of both University Nove de Julho (UNINOVE) and Lusiada Universitary Center (UNILUS) with approval from the Ethics Committee for Animal Research. Animals were separated into groups: (1) C: Normoglycemic control water; (2) CE: Normoglycemic control group that received hydroethanolic extract (GWA); (3) DM1 + GWA: Diabetic group that received extract GWA; and (4) DM1: Diabetic group that received water. The treatment was evaluated over a 30-day period. Food and water were weighted, and blood plasma biochemical analysis performed. Results: G. lucidum extract contained beta-glucan, proteins and phenols. Biochemical analysis indicated a decrease of plasma glycemic and lipid levels in DM rats induced with streptozotocin and treated with GWA extract. Histopathological analysis from pancreas of GWA-treated DM animals showed preservation of up to 50% of pancreatic islet total area when compared to the DM control group. In plasma, Kyn was present in diabetic rats, while in treated diabetic rats more Trp was detected. Conclusion: Evaluation from G. lucidum extract in STZ-hyperglycemic rats indicated that the extract possesses hypoglycemic and hypolipidemic activities. Support: Proj. CNPq 474681/201.

Download Full-text