Flutamide-Induced Blockade of Androgen Receptors Affects the Liver External Secretory Function in Rats

2018 ◽  
Vol 9 (3) ◽  
pp. 195-202
Author(s):  
Iryna S. Chernuha ◽  
Yevdokiya M. Reshetnik ◽  
Stanislav P. Veselsky ◽  
Alexander G. Reznikov ◽  
Mykola Yu. Makarchuk
Keyword(s):  
Androgen Receptors ◽  
Secretory Function

scholarly journals THE RATS LIVER EXTERNAL SECRETORY FUNCTION IN BLOCKADE OF ANDROGEN RECEPTORS WITH FLUTAMIDE

2017 ◽  
Vol 63 (5) ◽  
pp. 21-27
Author(s):  
I.S. Chernuha ◽  
◽  
Ye.M. Reshetnik ◽  
S.P. Veselsky ◽  
A.G. Reznikov ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Secretory Function

Control of Secretory Production in the Isopod Hepatopancreas

1972 ◽  
Vol 30 ◽  
pp. 166-167
Author(s):  
John W. Roberts ◽  
E. R. Witkus
Keyword(s):  
B Cells ◽  
Morphological Data ◽  
Secretory Product ◽  
Secretory Function ◽  
Secretory Material ◽  
Blind Ending ◽  
Secretory Production ◽  
Regenerative Cells ◽  
Immature Cells ◽  
And Storage

The isopod hepatopancreas, as exemplified by Oniscus ascellus. is comprised of four blind-ending diverticula. The regenerative cells at the tip of each diverticula differentiate into either club-shaped B-cells, which serve a secretory function, or into conoid S-cells, which serve in the absorption and storage of nutrients.The glandular B-cells begin producing secretory material with the development of rough endoplasmic reticulum during their process of maturation from the undifferentiated regenerative cells. Cytochemical and morphological data indicate that the hepatopancreas sequentially produces two types of secretory material within the large club-shaped cells. The production of the carbohydrate-like secretory product in immature cells seems to be phased out as the production of the osmiophilic secretion was phased in as the cell matured.

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

267: Effects of Steroidal and Non-Steroidal Antiandrogens on Wild-Type and Mutant Androgen Receptors

2007 ◽  
Vol 177 (4S) ◽  
pp. 89-90
Author(s):  
Masayasu Urushibara ◽  
Yukio Kageyama ◽  
Junichiro Ishioka ◽  
Yotsuo Higashi ◽  
Shuntaro Hara ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Wild Type

The Variation in Secretory Function of Different Regions of the Human Colon

Endoscopy ◽  
2006 ◽  
Vol 38 (11) ◽  
Author(s):  
A Patel ◽  
DL Bovell ◽  
AD Corbett ◽  
RJ Holdsworth
Keyword(s):  
Human Colon ◽  
Secretory Function

ZUM WIRKUNGSMECHANISMUS VON AN FETEN ANTIMASKULIN WIRKSAMEN GESTAGENEN

1964 ◽  
Vol 45 (4_Suppl) ◽  
pp. S139-S153 ◽  
Author(s):  
K. Junkmann ◽  
F. Neumann
Keyword(s):  
Pituitary Gland ◽  
Mechanism Of Action ◽  
Androgen Receptors ◽  
Male Rat ◽  
Pregnant Rats ◽  
Target Organs ◽  
Causative Factors ◽  
Competitive Action ◽  
Androgenic Effect

ABSTRACT Experiments are described dealing with the mechanism of action of 6-chloro-Δ6-1,2α-methylene-17α-hydroxyprogesterone-acetate with regard to its anti-masculine effect on male rat foetuses, when administered to pregnant rats. It was shown that a marked direct anti-androgenic effect due to a competitive action on androgen receptors within the target organs, is probably the explanation of the mechanism of action. It was further shown that an oestrogenic effect or an appreciable inhibition of the pituitary gland respectively, can be ruled out as causative factors in the mechanism of action.

THE EFFECT OF ESTRADIOL AND MESTEROLONE ON THE CONCENTRATIONS OF CYTOPLASMIC ESTROGEN AND ANDROGEN RECEPTORS

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S146
Author(s):  
A. Hughes ◽  
P. W. Jungblut
Keyword(s):  
Androgen Receptors
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