Radioprotective Effects of Aloe Vera Leaf Extract on Swiss Albino Mice against Whole-Body Gamma Irradiation

2009 ◽  
Vol 28 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Pradeep Kumar Goyal ◽  
Prashasnika Gehlot
Keyword(s):  
Gamma Irradiation ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Whole Body ◽  
Swiss Albino Mice ◽  
Albino Mice

Protection of swiss albino mice against whole-body gamma irradiation byMentha piperita(Linn.)

2004 ◽  
Vol 18 (7) ◽  
pp. 546-550 ◽  
Author(s):  
R. M. Samarth ◽  
P. K. Goyal ◽  
Ashok Kumar
Keyword(s):  
Gamma Irradiation ◽  
Whole Body ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Prevention of radiation-induced hepatic damage in Swiss albino mice by Aloe Vera leaf extract

2010 ◽  
Vol 25 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Prashasnika Gehlot ◽  
Dhanraj Soyal ◽  
Pradeep Goyal
Keyword(s):  
Lipid Peroxidation ◽  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice ◽  
Effects Of Radiation ◽  
Induced Changes

The radioprotective effect of the Aloe vera leaf extract was studied in Swiss albino mice against radiation-induced changes in the liver. The mice were treated with 1000 mg/kg of body weight orally, once a day for 15 consecutive days, before exposure to a single dose of gamma radiation (6 Gy), half an hour after the last administration. The irradiation of mice caused a significant elevation in lipid peroxidation followed by a decrease in glutathione, acid phosphatase and alkaline phosphatase. The treatment of mice before irradiation elevated the glutathione, acid phosphatase and alkaline phosphatase, and was accompanied by a decline in lipid peroxidation. Recovery and regeneration from radiation damage were faster in pretreated animals than the animals in the irradiation-only group. The data clearly indicate that the Aloe vera leaf extract significantly reduced the deleterious effects of radiation on the liver and it could be a useful agent in reducing the side effects of therapeutic radiation.

Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice

2007 ◽  
Vol 170 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Vipan Kumar Parihar ◽  
Jatin Dhawan ◽  
Suryakant Kumar ◽  
S.N. Manjula ◽  
G. Subramanian ◽  
...  
Keyword(s):  
Free Radical ◽  
Gamma Irradiation ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Whole Body ◽  
Radioprotective Activity ◽  
Swiss Albino Mice ◽  
Albino Mice

Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice

2007 ◽  
Vol 557 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Vipan Kumar Parihar ◽  
Koiram Rajanna Prabhakar ◽  
Veeresh Prabhakar Veerapur ◽  
Kavirayani Indira Priyadarsini ◽  
Mazhuvancherry Kesavan Unnikrishnan ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Whole Body ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Vernonia Amygdalina Del (Bitter Leaf) extract ameliorates isoniazid (INH) induced liver injury in Swiss Albino Mice

2018 ◽  
Author(s):  
Gebreselassie Addisu Tilaye ◽  
Muluken Fekadie Zerihun ◽  
Kasaw Adane Chuffa ◽  
Mahelet Arayaselassie ◽  
Daniel Seifu
Keyword(s):  
Liver Injury ◽  
Leaf Extract ◽  
Drug Clearance ◽  
Vernonia Amygdalina ◽  
Drug Induced ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Antitubercular Drugs ◽  
Toxic Injury ◽  
Albino Mice

AbstractLiver plays a central role in the metabolism of drugs. Drug clearance and transformation exposes liver to toxic injury. Antitubercular drugs have been found to be hepatotoxic and potentially lead to drug-induced liver injury. Isoniazid is one of the most hepatotoxic first line antitubercular drugs. Conventional drugs used in the treatment of liver disease are often inadequate and a search for supplementation or alternative drugs for the treatment of hepatic damage is indispensible. Therefore our study aims to investigate the hepatoprotective potential of Vernonia Amygdalina Del (bitter leaf) extract against Isoniazid-induced liver injury in Swiss Albino Mice. Treatment of Mice orally with Vernonia Amygdalina Del extract at dose of 250mg/kg and 375 mg/kg significantly lowered (P<0.05) the serum level of liver enzymes in Isoniazid pretreated mice. The hepatoptotective activity of the extract found to be comparable with the standard drug, Silymarin (100 mg/kg, P.o.). Moreover, treatment with the extract significantly alleviated Isoniazid induced hepatic injury as supported by the photomicrographs of liver section of mice. The data shows aqueous Vernonia Amygdalina Del extract has a very promising hepatoprotective potential against isoniazid-induced liver injury.

scholarly journals RADIOPROTECTION OF ALOE VERA AGAINST BIOCHEMICAL ALTERATIONS IN SWISS ALBINO MICE

2018 ◽  
Vol 10 (3) ◽  
pp. 55
Author(s):  
Priyanka Dadupanthi
Keyword(s):  
Radiation Treatment ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aloe Vera ◽  
Radiation Energy ◽  
Tissue Water ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

Objective: In this study, radioprotection against radiation-induced hepatic damage in Swiss Albino Mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals.Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5,10 and 20 after irradiation to evaluate the radio modulator effect in terms of LPO and GSH.Results: Radiation treatment showed a decrease in GSH content and an increase of LPO in control set animals, however, the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO but values remained below normal.Conclusion: The result of present study suggests that Aloe vera has a radioprotective effect due to their antioxidant and radical scavenging activity.

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