scholarly journals RADIOPROTECTION OF ALOE VERA AGAINST BIOCHEMICAL ALTERATIONS IN SWISS ALBINO MICE

2018 ◽  
Vol 10 (3) ◽  
pp. 55
Author(s):  
Priyanka Dadupanthi
Keyword(s):  
Radiation Treatment ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aloe Vera ◽  
Radiation Energy ◽  
Tissue Water ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

Objective: In this study, radioprotection against radiation-induced hepatic damage in Swiss Albino Mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals.Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5,10 and 20 after irradiation to evaluate the radio modulator effect in terms of LPO and GSH.Results: Radiation treatment showed a decrease in GSH content and an increase of LPO in control set animals, however, the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO but values remained below normal.Conclusion: The result of present study suggests that Aloe vera has a radioprotective effect due to their antioxidant and radical scavenging activity.

scholarly journals Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

2010 ◽  
Vol 10 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Preeti Verma ◽  
Priyanka Sharma ◽  
Jyoti Parmar ◽  
Priyanka Sharma ◽  
Annapurna Agrawal ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Ginseng Extract ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

scholarly journals Prevention of radiation-induced hepatic damage in Swiss albino mice by Aloe Vera leaf extract

2010 ◽  
Vol 25 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Prashasnika Gehlot ◽  
Dhanraj Soyal ◽  
Pradeep Goyal
Keyword(s):  
Lipid Peroxidation ◽  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice ◽  
Effects Of Radiation ◽  
Induced Changes

The radioprotective effect of the Aloe vera leaf extract was studied in Swiss albino mice against radiation-induced changes in the liver. The mice were treated with 1000 mg/kg of body weight orally, once a day for 15 consecutive days, before exposure to a single dose of gamma radiation (6 Gy), half an hour after the last administration. The irradiation of mice caused a significant elevation in lipid peroxidation followed by a decrease in glutathione, acid phosphatase and alkaline phosphatase. The treatment of mice before irradiation elevated the glutathione, acid phosphatase and alkaline phosphatase, and was accompanied by a decline in lipid peroxidation. Recovery and regeneration from radiation damage were faster in pretreated animals than the animals in the irradiation-only group. The data clearly indicate that the Aloe vera leaf extract significantly reduced the deleterious effects of radiation on the liver and it could be a useful agent in reducing the side effects of therapeutic radiation.

scholarly journals Evaluation of Anti-Inflammatory and Analgesic Activities of Methanolic Extract of Aitchisonia Rosea in Albino Mice

2020 ◽  
Vol 8 (1) ◽  
pp. 31-36
Author(s):  
Shahid Rasool ◽  
Ambreen Malik Uttra ◽  
Mehreen Malik Uttra ◽  
Faheem Ahmed ◽  
Khizar Abbas
Keyword(s):  
Acetic Acid ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Paw Edema ◽  
Egg Albumin ◽  
Inflammatory Conditions ◽  
Albino Mice ◽  
Anti Inflammatory

Objective:  Current analysis aims at in-vivo investigation of analgesic and anti-inflammatory activities of Aitchisonia rosea methanolic extract. Methods: Albino mice (20-30 g) were used in the study. Extract at 200, 400 and 800 mg/kg doses was tested against egg albumin and carrageenan induced mice paw edema along with formalin persuaded paw licking and acetic acid prompted writhing for analgesic activity. Results: Results depicted dose reliant and significant (p<0.001) inhibition of carrageenan as well as egg albumin brought paw edema, abdominal constrictions/ hind limb stretching tempted by acetic acid and formalin instigated paw licking. Capability of crude extract to halt inflammatory and analgesic response was akin to that of ibuprofen in all models. Conclusion: The current findings support the use of Aitchisonia rosea for inflammatory conditions, which might be attributed to its previously proven high alkaloid, flavonoids, phenol, tannins content and free radical scavenging activity.

scholarly journals EFFECT OF OPUNTIA ELATIOR ON CHOLESTEROL LEVEL ALTERATIONS INDUCED BY GAMMA RADIATION IN SWISS ALBINO MICE

2019 ◽  
pp. 578-581
Author(s):  
KAVITA POONIAM ◽  
JAIMALA SHARMA
Keyword(s):  
Side Effects ◽  
Gamma Radiation ◽  
Cholesterol Level ◽  
Plant Extract ◽  
Treated Group ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice

Objectives: Radiotherapy is deleterious to patient health by making the patient more susceptible to other diseases and often causes death by weakening the immune system and also affects cholesterol level. Based on these studies, it was moved toward the selection of Opuntia elatior as a herbal remedy for serum cholesterol level induced by gamma radiation. Methods: The modulatory effect of O. elatior stem extract was studied in Swiss albino mice at dose, i.e., 6 Gy of gamma radiation in the presence (experimental) or absence (control) of O. elatior extract (OEE) (10 mg/kg body weight) to observe in blood cholesterol level alterations. The animals were scarified and their blood was collected at days 1, 15, and 30 post-irradiation from heart puncture. Cholesterol level was estimated by the modified method of Roeschlau et al., 1974, using kit. Results: The cholesterol level was found almost constant in the control group (without any treatment) and increased in gamma radiation-treated group and decreased in only plant extract-treated group, whereas radiation-induced increased level of cholesterol was reduced by plant extract treatment in experimental animals (in plant extract with radiation-treated group), a normal level was achieved by day 30 post-treatment. Hence, O. elatior is beneficial to control radiation-induced blood cholesterol level. Conclusion: Radiation-induced side effects get lowered by herbal treatment and herbal products do not have their own side effects on body on their physical and chemical processes; thus, OEE is useful to manage blood cholesterol level as an edible part, it is easy to use as treatment and in my results OEE also support to maintain cholesterol level in serum of mice.

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