scholarly journals Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers

2015 ◽  
Vol 16 (12) ◽  
pp. 1019-1026 ◽  
Author(s):  
Hua-li Li ◽  
Zong-jun Li ◽  
Zhong-shan Wei ◽  
Ting Liu ◽  
Xiao-zuo Zou ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Digestive Enzymes ◽  
Lactobacillus Brevis ◽  
Tea Polyphenols ◽  
Long Term Effects

scholarly journals Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats

Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 263 ◽  
Author(s):  
Yingli Yu ◽  
Pengli Wang ◽  
Ruili Yu ◽  
Jiaxi Lu ◽  
Miaomiao Jiang ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Female Rats ◽  
Proton Nuclear Magnetic Resonance ◽  
Long Term Effects ◽  
Serum Samples ◽  
Drug Induced ◽  
Clinical Safety ◽  
Tissue Samples ◽  
Unsaturated Lipids

Pre-clinical safety evaluation of traditional medicines is imperative because of the universality of drug-induced adverse reactions. Psoralen and isopsoralen are the major active molecules and quality-control components of a traditional herbal medicine which is popularly used in Asia, Fructus Psoraleae. The purpose of this study is to assess the long-term effects of psoralen and isopsoralen with low levels on the biochemical parameters and metabolic profiles of rats. Three doses (14, 28, and 56 mg/kg) of psoralen and one dose (28 mg/kg) of isopsoralen were administered to rats over 12 weeks. Blood and selected tissue samples were collected and analyzed for hematology, serum biochemistry, and histopathology. Metabolic changes in serum samples were detected via proton nuclear magnetic resonance (1H-NMR) spectroscopy. We found that psoralen significantly changed the visceral coefficients, blood biochemical parameters, and histopathology, and isopsoralen extra influenced the hematological index. Moreover, psoralen induced remarkable elevations of forvaline, isoleucine, isobutyrate, alanine, acetone, pyruvate, glutamine, citrate, unsaturated lipids, choline, creatine, phenylalanine, and 4-hydroxybenzoate, and significant reductions of ethanol and dimethyl sulfone. Isopsoralen only induced a few remarkable changes of metabolites. These results suggest that chronic exposure to low-level of psoralen causes a disturbance in alanine metabolism, glutamate metabolism, urea cycle, glucose-alanine cycle, ammonia recycling, glycine, and serine metabolism pathways. Psoralen and isopsoralen showed different toxicity characteristics to the rats.

Long-term effects of thyroid fine-needle biopsy on the thyroid-related biochemical parameters

2012 ◽  
Vol 66 (6) ◽  
pp. 602-609 ◽  
Author(s):  
A. D. Anastasilakis ◽  
S. A. Polyzos ◽  
S. Delaroudis ◽  
K. A. Toulis ◽  
S. Mandanas ◽  
...  
Keyword(s):  
Needle Biopsy ◽  
Biochemical Parameters ◽  
Fine Needle Biopsy ◽  
Long Term Effects ◽  
Fine Needle

Prognostic factors and long-term effects of ursodeoxycholic acid on liver biochemical parameters in patients with primary biliary cirrhosis

1999 ◽  
Vol 31 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Hubert J.F van Hoogstraten ◽  
Bettina E Hansen ◽  
Henk R van Buuren ◽  
Fiebo J.W ten Kate ◽  
Gerard P van Berge-Henegouwen ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Biochemical Parameters ◽  
Biliary Cirrhosis ◽  
Long Term Effects

Long-term effects of soybean protease inhibitors on digestive enzymes, survival and learning abilities of honeybees

2000 ◽  
Vol 95 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Minh-Ha Pham-Delegue ◽  
Cecile Girard ◽  
Martine Metayer ◽  
Anne-Lorraine Picard-Nizou ◽  
Christelle Hennequet ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Digestive Enzymes ◽  
Long Term Effects ◽  
Learning Abilities

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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