Correlation of Murine Embryonic Stem Cell Gene Expression Profiles with Functional Measures of Pluripotency

Stem Cells ◽  
2005 ◽  
Vol 23 (5) ◽  
pp. 663-680 ◽  
Author(s):  
Lars Palmqvist ◽  
Clive H. Glover ◽  
Lien Hsu ◽  
Min Lu ◽  
Bolette Bossen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Expression Profiles ◽  
Embryonic Stem ◽  
Gene Expression Profiles ◽  
Murine Embryonic Stem Cell ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Stem Cell Gene

scholarly journals Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set

2006 ◽  
Vol 2 (11) ◽  
pp. e158 ◽  
Author(s):  
Clive H. Glover ◽  
Michael Marin ◽  
Connie J. Eaves ◽  
Cheryl D. Helgason ◽  
James M. Piret ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Meta Analysis ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Early Change ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Stem Cell Gene

scholarly journals Retrotransposons shape species-specific embryonic stem cell gene expression

Retrovirology ◽  
2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Luisa Robbez-Masson ◽  
Helen M Rowe
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Cell Gene Expression ◽  
Species Specific ◽  
Cell Gene ◽  
Stem Cell Gene

scholarly journals The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Wei Yang ◽  
Yun-Hwa Lee ◽  
Amanda E. Jones ◽  
Jessica L. Woolnough ◽  
Dewang Zhou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Lineage Commitment ◽  
Histone H2a ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Stem Cell Gene

Evaluation of Novel Mouse-Specific Germ Cell Gene Expression in Embryonic Stem Cell-Derived Germ Cell-Like CellsIn Vitrowith Retinoic Acid Treatment

2018 ◽  
Vol 20 (4) ◽  
pp. 245-255 ◽  
Author(s):  
Maryam Gholamitabar Tabari ◽  
Seyed Gholam Ali Jorsaraei ◽  
Mohammad Ghasemzadeh-Hasankolaei ◽  
Ali Asghar Ahmadi ◽  
Mehdi Amirikia
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Retinoic Acid ◽  
Germ Cell ◽  
Embryonic Stem Cell ◽  
Acid Treatment ◽  
Embryonic Stem ◽  
Retinoic Acid Treatment ◽  
Cell Gene Expression ◽  
Cell Gene

Gene Expression Profiles of Similarly Derived Human Embryonic Stem Cell Lines Correlate with Their Distinct Propensity to Exit Stemness and Their Different Differentiation Behavior in Culture

2014 ◽  
Vol 16 (3) ◽  
pp. 185-195 ◽  
Author(s):  
Oliver Sterthaus ◽  
Anne-Catherine Feutz ◽  
Hong Zhang ◽  
Flurina Pletscher ◽  
Elisabeth Bruder ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Lines ◽  
Human Embryonic Stem Cell ◽  
Expression Profiles ◽  
Embryonic Stem ◽  
Gene Expression Profiles ◽  
Stem Cell Lines

The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile

Blood ◽  
2002 ◽  
Vol 99 (7) ◽  
pp. 2285-2290 ◽  
Author(s):  
James Z. Huang ◽  
Warren G. Sanger ◽  
Timothy C. Greiner ◽  
Louis M. Staudt ◽  
Dennis D. Weisenburger ◽  
...  
Keyword(s):  
Gene Expression ◽  
B Cell ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Germinal Center ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Germinal Center B Cell ◽  
Cell Gene Expression ◽  
Cell Gene

Recently we have identified subgroups of de novo primary diffuse large B-cell lymphoma (DLBCL) based on complementary DNA microarray-generated gene expression profiles. To correlate the gene expression profiles with cytogenetic abnormalities in these DLBCLs, we examined the occurrence of the t(14;18)(q32;q21) in the 2 distinctive subgroups of DLBCL: one with the germinal center B-cell gene expression signature and the other with the activated B cell–like gene expression signature. The t(14;18) was detected in 7 of 35 cases (20%). All 7 t(14;18)-positive cases had a germinal center B-cell gene expression profile, representing 35% of the cases in this subgroup, and 6 of these 7 cases had very similar gene expression profiles. The expression of bcl-2 and bcl-6 proteins was not significantly different between the t(14;18)-positive and -negative cases, whereas CD10 was detected only in the group with the germinal center B-cell expression profile, and CD10 was most frequently expressed in the t(14;18)-positive cases. This study supports the validity of subdividing DLBCL into 2 major subgroups by gene expression profiling, with the t(14;18) being an important event in the pathogenesis of a subset of DLBCL arising from germinal center B cells. CD10 protein expression is useful in identifying cases of DLBCL with a germinal center B-cell gene expression profile and is often expressed in cases with the t(14;18).

scholarly journals The single-cell transcriptional landscape of lung carcinoid tumors

2021 ◽  
Author(s):  
Philip Bischoff ◽  
Alexandra Trinks ◽  
Jennifer Wiederspahn ◽  
Benedikt Obermayer ◽  
Jan Patrick Pett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Carcinoid Tumor ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Carcinoid Tumors ◽  
Cellular Composition ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Lung Carcinoid

AbstractLung carcinoid tumors, also referred to as pulmonary neuroendocrine tumors or lung carcinoids, are rare neoplasms of the lung with a more favorable prognosis than other subtypes of lung cancer. Still, some patients suffer from relapsed disease and metastatic spread while no consensus treatment exists for metastasized carcinoids. Several recent single-cell studies have provided detailed insights into the cellular heterogeneity of more common lung cancers, such as adeno- and squamous cell carcinoma. However, the characteristics of lung carcinoids on the single-cell level are yet completely unknown.To study the cellular composition and single-cell gene expression profiles in lung carcinoids, we applied single-cell RNA sequencing to three lung carcinoid tumor samples and normal lung tissue. The single-cell transcriptomes of carcinoid tumor cells reflected intertumoral heterogeneity associated with clinicopathological features, such as tumor necrosis and proliferation index. The immune microenvironment was specifically enriched in noninflammatory monocyte-derived myeloid cells. Tumor-associated endothelial cells were characterized by distinct gene expression profiles. A spectrum of vascular smooth muscle cells and pericytes predominated the stromal microenvironment. We found a small proportion of myofibroblasts exhibiting features reminiscent of cancer-associated fibroblasts. Stromal and immune cells exhibited potential paracrine interactions which may shape the microenvironment via NOTCH, VEGF, TGFβ and JAK/STAT signaling. Moreover, single-cell gene signatures of pericytes and myofibroblasts demonstrated prognostic value in bulk gene expression data.Here, we provide first comprehensive insights into the cellular composition and single-cell gene expression profiles in lung carcinoids, demonstrating the non-inflammatory and vessel-rich nature of their tumor microenvironment, and outlining relevant intercellular interactions which could serve as future therapeutic targets.

scholarly journals A stem cell gene expression profile of human squamous cell carcinomas

2008 ◽  
Vol 272 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Kim B. Jensen ◽  
Judith Jones ◽  
Fiona M. Watt
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Stem Cell Gene
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