Distinct Clinicopathological Features and Prognosis of Emerging Young‐Female Breast Cancer in an East Asian Country: A Nationwide Cancer Registry‐Based Study

PurposeThis study aimed to determine the incidence of male breast cancer (MBC) and its survival outcomes in Korea, and to compare these results to those for female breast cancer (FBC).Materials and MethodsWe searched the Korea Central Cancer Registry and identified 227,122 breast cancer cases that were diagnosed between 1999 and 2016. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to sex, age, histological type, and cancer stage.ResultsThe 227,122 patients included 1,094 MBC cases and 226,028 FBC cases. Based on the age-standardized rate, the male: female ratio was 0.0055:1. The most common ages at diagnosis were 60-69 years for MBC and 40-49 years for FBC (p < 0.001). Male patients were less likely than female patients to receive adjuvant radiotherapy (7.5% vs. 21.8%, p < 0.001) or adjuvant chemotherapy (40.1% vs. 55.4%, p < 0.001). The 5-year OS rates after diagnosis were 88.8% for all patients, although it was significantly lower for MBC than for FBC (76.2% vs. 88.9%, p < 0.001). In both groups, older age (≥ 60 years) was associated with shorter survival. The 5-year OS rates for the invasive histological types were 75.8% for men and 89.0% for women. The 5-year OS rates in both groups decreased with increasing cancer stage.ConclusionMBC was diagnosed at older ages than FBC, and male patients were less likely to receive radiotherapy and chemotherapy. The survival outcomes were worse for MBC than for FBC, with even poorer outcomes related to older age, the inflammatory histological types, and advanced stage. It is important that clinicians recognize the differences between FBC and MBC when treating these patients.

Download Full-text

Comparison of epidemiological features, clinicopathological features, and treatments between premenopausal and postmenopausal female breast cancer patients in western China: a retrospective multicenter study of 15,389 female patients

Cancer Medicine ◽

10.1002/cam4.1503 ◽

2018 ◽

Vol 7 (6) ◽

pp. 2753-2763 ◽

Cited By ~ 3

Author(s):

Fan Feng ◽

Yuxian Wei ◽

Ke Zheng ◽

Yujing Li ◽

Lu Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Female Breast Cancer ◽

Clinicopathological Features ◽

Western China ◽

Breast Cancer Patients ◽

Epidemiological Features ◽

Female Breast ◽

Postmenopausal Female ◽

Retrospective Multicenter Study

Download Full-text

Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djz090 ◽

2019 ◽

Vol 111 (12) ◽

pp. 1298-1306 ◽

Cited By ~ 13

Author(s):

Ching-Hung Lin ◽

Yoon Sim Yap ◽

Kyung-Hun Lee ◽

Seock-Ah Im ◽

Yoichi Naito ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

East Asian ◽

Female Breast Cancer ◽

Asian Women ◽

Regression Analyses ◽

Pathological Characteristics ◽

Female Breast ◽

Estrogen Receptor Positivity ◽

The Us

Abstract Background The incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in East Asian women and women of predominantly European ancestry. Methods We excerpted analytic data from six national cancer registries (979 675 cases) and eight hospitals (18 008 cases) in East Asian countries and/or regions and, for comparisons, from the US Surveillance, Epidemiology, and End Results program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided. Results Unlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged 59 years and younger increased disproportionally over recent decades relative to rates in US contemporaries. For years 2010–2014, the estimated age-specific probability of estrogen receptor positivity increased with age in American patients, whereas that of triple-negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients; their probability of estrogen receptor positivity at age 40–49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI] = 1.36 to 1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI = 0.71 to 0.88, P < .001), whereas the probability of ER positivity at age 50–59 years was statistically significantly lower (OR = 0.88, 95% CI = 0.828 to 0.95, P < .001). Subgroup analyses of US Surveillance, Epidemiology, and End Results data showed similarly distinct patterns between East Asian American and white American patients. Conclusions Contrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology.

Download Full-text

The Exercise Profile of a Young Female Breast Cancer Survivor Prior to and After Diagnosis

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000401551.23123.ad ◽

2011 ◽

Vol 43 (Suppl 1) ◽

pp. 563

Author(s):

Scott N. Drum ◽

Riggs J. Klika

Keyword(s):

Breast Cancer ◽

Cancer Survivor ◽

Breast Cancer Survivor ◽

Young Female ◽

Female Breast Cancer ◽

Female Breast

Download Full-text

Improving Visualization of Female Breast Cancer Survival Estimates: Analysis Using Interactive Mapping Reports (Preprint)

10.2196/preprints.8163 ◽

2017 ◽

Author(s):

Awatef Ahmed Ben Ramadan ◽

Jeannette Jackson-Thompson ◽

Chester Lee Schmaltz

Keyword(s):

Public Health ◽

Breast Cancer ◽

Cancer Registry ◽

Survival Data ◽

Cancer Survival ◽

Female Breast Cancer ◽

Breast Cancer Survival ◽

National Death Index ◽

Interactive Mapping ◽

Female Breast

BACKGROUND The Missouri Cancer Registry collects population-based cancer incidence data on Missouri residents diagnosed with reportable malignant neoplasms. The Missouri Cancer Registry wanted to produce data that would be of interest to lawmakers as well as public health officials at the legislative district level on breast cancer, the most common non-skin cancer among females. OBJECTIVE The aim was to measure and interactively visualize survival data of female breast cancer cases in the Missouri Cancer Registry. METHODS Female breast cancer data were linked to Missouri death records and the Social Security Death Index. Unlinked female breast cancer cases were crossmatched to the National Death Index. Female breast cancer cases in subcounty senate districts were geocoded using TIGER/Line shapefiles to identify their district. A database was created and analyzed in SEER*Stat. Senatorial district maps were created using US Census Bureau’s cartographic boundary files. The results were loaded with the cartographic data into InstantAtlas software to produce interactive mapping reports. RESULTS Female breast cancer survival profiles of 5-year cause-specific survival percentages and 95% confidence intervals, displayed in tables and interactive maps, were created for all 34 senatorial districts. The maps visualized survival data by age, race, stage, and grade at diagnosis for the period from 2004 through 2010. CONCLUSIONS Linking cancer registry data to the National Death Index database improved accuracy of female breast cancer survival data in Missouri and this could positively impact cancer research and policy. The created survival mapping report could be very informative and usable by public health professionals, policy makers, at-risk women, and the public.

Download Full-text