scholarly journals Tumorigenicity of MCF-7 human breast cancer cells lacking the p38  mitogen-activated protein kinase

2010 ◽  
Vol 208 (1) ◽  
pp. 11-19 ◽  
Author(s):  
R. A. Mendoza ◽  
E. E. Moody ◽  
M. I. Enriquez ◽  
S. M. Mejia ◽  
G. Thordarson
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mitogen Activated Protein ◽  
Mcf 7

scholarly journals Analysis and Anticancer Effects of Active Compounds from Spatholobi Caulis in Human Breast Cancer Cells

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1193
Author(s):  
Hung Manh Phung ◽  
Hesol Lee ◽  
Sullim Lee ◽  
Dongyeop Jang ◽  
Chang-Eop Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Gallic Acid ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Anticancer Effects ◽  
Mcf 7

Breast cancer is the most common malignancy in both developing and developed countries. In this study, we simultaneously analyzed nine constituent compounds from Spatholobi Caulis (gallic acid, (−)-gallocatechin, 3,4-dihydroxybenzoic acid, procyanidin B1, 3,4-dihydroxybenzaldehyde, catechin, procyanidin B2, epicatechin, and (−)-epicatechin gallate) and examined their anticancer effects on MCF-7 and MDA-MB-231 human breast cancer cells. The experimental results indicated that the gallic acid showed the strongest cytotoxic effect on MCF-7 cells among tested compounds whilst most of samples did not express inhibitory effect on viability of MDA-MB-231 cells, except for 70% ethanol extract of S. Caulis. Thus, gallic acid was chosen to extend anticancer mechanism study on MCF-7 cells. Our data showed that the gallic acid induced apoptotic MCF-7 cell death through both extrinsic and intrinsic pathways, which increased the expression of cleaved caspase-7, -8, and -9, Bax and p53, but reduced the expression of Bcl-2 and poly (ADP-ribose) polymerase (PARP). In addition, the network pharmacological analysis pointed out that the p53, mitogen-activated protein kinase (MAPK), estrogen, and Wnt signaling pathways have a great correlation with the targets of gallic acid. This study suggested that gallic acid is a bioactive component of S. Caulis with potential to be used in chemotherapy for breast cancer.

scholarly journals Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2

2014 ◽  
Vol 35 (3) ◽  
pp. 815-820 ◽  
Author(s):  
YUNYAN WU ◽  
HIDENOBU SATO ◽  
TAKAHIRO SUZUKI ◽  
TADASHI YOSHIZAWA ◽  
SATOKO MOROHASHI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Bhlh Transcription Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7
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