BLOOD FLOW CHANGES IN THE PITUITARY NEURAL LOBE OF THE RABBIT ASSOCIATED WITH NEUROHYPOPHYSIAL HORMONE-RELEASING STIMULI
SUMMARY Blood flow rates in the posterior pituitary glands of rabbits were calculated by measuring the clearance of locally deposited 133Xe in saline detected by an externally located probe. These studies indicated that intraarterial injection of CaCl2 and central stimulation of a vagus (both hormone-releasing stimuli) caused a significant rise in blood flow, whilst during haemorrhage, also a release stimulus, the blood flow in the posterior pituitary was maintained. Pretreatment with atropine abolished the increase seen with CaCl2 and vagal stimulation and caused a significant fall in blood flow after haemorrhage. Parasympathomimetic drugs caused an increase in the flow which was also atropine-sensitive; sympathomimetic drugs and sympathetic blocking drugs caused no alteration in blood flow. These results indicate that there is a local increase in blood flow in the posterior pituitary which is associated with hormone-releasing stimuli and which is cholinergically mediated.