BLOOD FLOW CHANGES IN THE PITUITARY NEURAL LOBE OF THE RABBIT ASSOCIATED WITH NEUROHYPOPHYSIAL HORMONE-RELEASING STIMULI

1973 ◽  
Vol 57 (1) ◽  
pp. 75-85 ◽  
Author(s):  
T. SOORIYAMOORTHY ◽  
A. LIVINGSTON

SUMMARY Blood flow rates in the posterior pituitary glands of rabbits were calculated by measuring the clearance of locally deposited 133Xe in saline detected by an externally located probe. These studies indicated that intraarterial injection of CaCl2 and central stimulation of a vagus (both hormone-releasing stimuli) caused a significant rise in blood flow, whilst during haemorrhage, also a release stimulus, the blood flow in the posterior pituitary was maintained. Pretreatment with atropine abolished the increase seen with CaCl2 and vagal stimulation and caused a significant fall in blood flow after haemorrhage. Parasympathomimetic drugs caused an increase in the flow which was also atropine-sensitive; sympathomimetic drugs and sympathetic blocking drugs caused no alteration in blood flow. These results indicate that there is a local increase in blood flow in the posterior pituitary which is associated with hormone-releasing stimuli and which is cholinergically mediated.

The effect of haemorrhage on aldosterone secretion was studied in anaesthetized dogs with intact pituitary glands and kidneys subjected to the stress of adrenal vein cannulation. The following observations were made: Acute haemorrhage was followed by a significant rise in aldosterone secretion in about one half of the animals studied. In most of the remaining dogs, called non-reactors, premature stimulation of aldosterone secretion before the withdrawal of blood appeared to be the cause for the lack of response. This stimulation was traced in many instances to prolonged surgical ‘stress’, in others to incipient circulatory failure. Another reason for a high initial secretion rate of aldosterone was low dietary sodium intake continued for a week or more. Increase in aldosterone secretion after haemorrhage was unimpaired by sectioning the vagi or the splanchnic nerves, and by the absence of the proprioceptors of carotid sinus and thyro-carotid junction, or of liver, spleen and gastrointestinal tract. During haemorrhage there is secretion of medullary amines and anoxia develops. The effect of these factors on aldosterone secretion was tested by infusing adrenaline and noradrenaline in the splanchnotomized animal, and by carrying out exchange transfusions with plasma till the dog had lost 50 % of its red cells. Provided the initial aldosterone secretion was low enough, these procedures caused small rises in output of aldosterone, but constituted less effective stimuli than blood loss. Glucocorticoid secretion was in all animals maximal or near maximal and changed but little in the course of the experiments. The findings suggest that, in the intact dog, aldosterone secretion is influenced by a variety of factors, most of which act indirectly by releasing ACTH , or renin, or both. The role of ACTH and of renin as mediators of the action of haemorrhage on secretion of aldosterone will be studied in part II.


2004 ◽  
Vol 35 (03) ◽  
Author(s):  
T Mildner ◽  
S Zysset ◽  
R Trampel ◽  
W Driesel ◽  
HE Möller

2017 ◽  
Vol 63 (5) ◽  
pp. 766-769
Author(s):  
Nikolay Agarkov ◽  
Pavel Tkachenko ◽  
Dmitriy Kicha ◽  
Vitaliy Aksenov ◽  
Aleksandr Ivanov ◽  
...  

Analysis of ultrasonic blood flow changes in uterine and ovarian arteries and veins in 92 patients with ovarian cancer and 87 patients with chronic salpingoophoritis has allowed to identify the leading differential diagnostic criteria, which include minimum diastolic blood flow velocity, resistance index, while fast hyperemia, the index of venous outflow diastolic index and index of peripheral resistance. Based on a selection of leading differential diagnostic criteria for ovarian cancer and chronic salpingoophoritis developed a network model of differentiation of these groups of patients, streamlining the differential diagnostic process


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