IgA Nephropathy Needs a Diagnostic Marker of Immunologic Activity to Select the Right Patients for Immunotherapies

2021 ◽  
pp. ASN.2021091239
Author(s):  
Marc Hilhorst ◽  
Hans-Joachim Anders
Keyword(s):  
Iga Nephropathy ◽  
Diagnostic Marker ◽  
The Right ◽  
Immunologic Activity

scholarly journals Blastic natural killer cell lymphoma/leukaemia in a cat

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691986308
Author(s):  
Miyuki Hirabayashi ◽  
James K Chambers ◽  
Mei Sugawara ◽  
Aki Ohmi ◽  
Hajime Tsujimoto ◽  
...  
Keyword(s):  
Natural Killer ◽  
Nk Cell ◽  
Diagnostic Marker ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
Killer Cell ◽  
Cross Reactivity ◽  
Diffuse Infiltration ◽  
Subcutaneous Mass ◽  
The Right

Case summary A 7-year-old mixed-breed cat presented with subcutaneous oedema and erythema extending from the right axilla to the abdomen. Fine-needle aspiration of the subcutaneous lesion revealed large, atypical, round cells. A clonality analysis for the T-cell receptor-gamma and immunoglobulin heavy chain genes showed no clonal rearrangement. The presumed diagnosis was lymphoma and the cat was treated with prednisolone and L-asparaginase but died 78 days after initial treatment. At necropsy, an oedematous subcutaneous mass in the right axilla, hepatomegaly, splenomegaly and lymphadenopathy of the mediastinum and left axilla were observed. Histopathological examination revealed diffuse infiltration of large atypical round cells in the subcutaneous mass, liver, spleen, lymph nodes and bone marrow. Immunohistochemically, the tumour cells were strongly positive for CD56, and negative for CD3, CD20, CD79a, CD57, granzyme B and perforin. Based on these findings, the cat was diagnosed with blastic natural killer (NK) cell lymphoma/leukaemia. Relevance and novel information Here, we report the pathological and clinical findings of NK cell lymphoma/leukaemia in a cat. The antibody for human CD56, a diagnostic marker for human NK cell neoplasms, showed cross-reactivity with feline CD56 by immunohistochemistry and Western blotting analysis. The antibody could be a useful diagnostic marker for feline NK cell neoplasms.

Optic Disc Drusenoid Deposits with Hemifield Defects in a Patient with IgA Nephropathy - New Findings

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Visual Field ◽  
Iga Nephropathy ◽  
Optic Disc ◽  
Urine Analysis ◽  
Leukocytoclastic Vasculitis ◽  
Visual Field Defects ◽  
Total Leucocyte Count ◽  
Cell Hyperplasia ◽  
New Findings ◽  
The Right

To describe emerging new OCT and Humphrey visual field findings is the objective of the study. A previously treated 20-year old female patient for skin rashes, hematuria, and pain abdomen 8 months ago reported with visual disruption in the right eye for the last one week. Features of leukocytoclastic vasculitis on skin biopsy and glomerular mesangial cell hyperplasia on renal biopsy inferred a clinical diagnosis of IgA nephropathy. Consequently, proteinuria manifested one month after administration of prednisolone 50 mg/day tapered for 8 months, Visual acuity of 6/9 in the right eye and 6/6 in the left eye with normal color vision recorded in addition to early signs of papilledema. Classically, on OCT, hyperreflective intense echoes discovered in the optic disc, and accordingly inferior hemifield defects established predominantly in the right eye on HFA. Total leucocyte count at11720 cells/cu mm and ESR 60 mm/hr by the Wintrobe method with the presence of albumin, RBCs, and pus cells on urine analysis in addition to positive occult stool blood detection. C3, C4, and ANCA panel revealed negative results and the USG abdomen disclosed fatty liver with mesenteric nodes. In conclusion, Optic disc drusenoid deposits corresponding with hemifield visual field defects detected in the current case study is possibly the associated early fundus manifestation of IgA nephropathy.

scholarly journals Pedunculated aortic thrombus propagating from the right coronary artery in a patient with IgA nephropathy

2018 ◽  
Vol 39 (32) ◽  
pp. 3000-3000
Author(s):  
Jacques Scherman ◽  
Natercia da Silva ◽  
Adriaan Myburgh ◽  
Timothy Pennel
Keyword(s):  
Coronary Artery ◽  
Iga Nephropathy ◽  
Right Coronary Artery ◽  
Aortic Thrombus ◽  
The Right

scholarly journals Multiscale Approximate Entropy for Gait Analysis in Patients with Neurodegenerative Diseases

Entropy ◽  
2019 ◽  
Vol 21 (10) ◽  
pp. 934
Author(s):  
An-Bang Liu ◽  
Che-Wei Lin
Keyword(s):  
Neurodegenerative Diseases ◽  
Diagnostic Marker ◽  
Neurological Diseases ◽  
Reaction Force ◽  
Approximate Entropy ◽  
Parkinson’S Diseases ◽  
Gait Abnormalities ◽  
The Right ◽  
Lateral Sclerosis

Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson’s diseases (PD), and Huntington’s disease (HD) are not rare neurological diseases. They affect different neurological systems and present various characteristic gait abnormalities. We retrieved gait signals of the right and left feet from a public domain on the Physionet. There were 13 patients with ALS, 15 patients with PD, 20 patients with HD and 16 healthy controls (HC). We used multiscale approximate entropy (MAE) to analyze ground reaction force on both feet. Our study shows that MAE increases with scales in all tested subjects. The group HD has the highest MAE and group ALS has the lowest MAE. We can differentiate ALS from HC by MAE, while scale factors >10 in the left foot. There are few significant differences of MAE between the HC and HD. We found a good correlation of MAE between both feet in group ALS. In conclusion, our results indicate that MAE analysis of gait signals can be used for diagnosis and long-term assessment for ALS and probably HD. Similarity of MAE between both feet can also be a diagnostic marker for ALS.

scholarly journals Melan-A Expression in Poorly Differentiated Carcinoma of Lung: A Potential Diagnostic Pitfall

2021 ◽  
Author(s):  
wenyong huang ◽  
Shuixian Li ◽  
Guofeng Zhu ◽  
Lei Zeng ◽  
Yueer Zheng ◽  
...  
Keyword(s):  
Diagnostic Marker ◽  
Large Mass ◽  
Melanocytic Tumors ◽  
Diagnostic Pitfall ◽  
Poorly Differentiated Carcinoma ◽  
First Case ◽  
Poorly Differentiated ◽  
Differentiation Marker ◽  
The Right ◽  
Melanocytic Differentiation

Abstract BackgroundMelan-A/MART-1 is a melanocytic differentiation marker, which is recognized as an antigen on melanoma cells. It is relevant for pathologists as a useful diagnostic marker in the diagnosis of melanocytic tumors. However, the expressional pattern of Melan-A in poorly differentiated carcinoma of lung has never been reported so far.Case presentationHere, we report a 77-year-old female patient who presented with a large mass in the right lung and was subsequently diagnosed with a poorly differentiated carcinoma of lung. We unexpectedly found that the carcinoma in this patient exhibited diffuse Melan-A expression. ConclusionThis is the first case reported of a poorly differentiated carcinoma of lung with Melan-A expression. This report shows that Melan-A can express in poorly differentiated carcinoma, and highlights a potential diagnostic pitfall in the diagnosis of carcinoma, which urges pathologists to exercise caution in cases where Melan-A positivity and illustrates the need for further immunohistochemical or molecular examination to avoid misdiagnosis.

scholarly journals Underglycosylation of IgA in IgA nephropathy: More than a diagnostic marker?

2007 ◽  
Vol 71 (11) ◽  
pp. 1089-1091 ◽  
Author(s):  
A. Roos ◽  
C. van Kooten
Keyword(s):  
Iga Nephropathy ◽  
Diagnostic Marker

scholarly journals IgA nephropathy presenting with pulmonary thromboembolism and renal artery infarct

2018 ◽  
Vol 8 (3) ◽  
pp. 29-29
Author(s):  
Madhav Venkatesan ◽  
Anil Mathew ◽  
Rajesh Nair ◽  
George Kurian ◽  
Seethalekshmy NV ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Urine Analysis ◽  
Previous History ◽  
Case Presentation ◽  
Arterial Thromboembolism ◽  
Pulmonary Angiogram ◽  
Cardiology Department ◽  
Ct Pulmonary Angiogram ◽  
The Right

Background: Venous and arterial thromboembolism are frequently seen in nephrotic syndrome. They generally occur during periods of sustained proteinuria in patients who are not responding to treatment and more commonly seen in minimal change disease and membranous nephropathy. Case Presentation: A 28-year-old male presented to cardiology department of our hospital with worsening breathlessness for 1 week. We found pulmonary embolism and an infarct in the lower pole of the right kidney by CT pulmonary angiogram. He had no previous history or features of nephrotic syndrome. Urine analysis showed numerous red blood cells, 3+ proteinuria and granular casts. Urine protein creatinine ratio was 5.2 g/g of creatinine. Serum creatinine was 2.61 mg/dL. Renal biopsy was suggestive of IgA nephropathy and patient was started on steroids and warfarin and responded to treatment. Conclusions: Patients with nephrotic syndrome can rarely present initially with venous and arterial thromboembolism. Rarely even IgA nephropathy can present with such thromboembolic episodes.

scholarly journals Case Report: Rare occurrence of Pseudomonas aeruginosa osteomyelitis of the right clavicle in a patient with IgA nephropathy

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 268 ◽  
Author(s):  
Aishwarya Damodaran ◽  
Anusha Rohit ◽  
Georgi Abraham ◽  
Sanjeev Nair ◽  
Anand Yuvaraj
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Renal Function ◽  
Iga Nephropathy ◽  
Rare Case ◽  
Complete Recovery ◽  
Immunocompetent Patient ◽  
Rare Occurrence ◽  
Immunosuppressive Medications ◽  
Appropriate Therapy ◽  
The Right

We describe the case of a 47 year old patient with proven primary IgA nephropathy who presented with osteomyelitis of the medial end of the right clavicle. The patient was not on immunosuppressive medications. He underwent aspiration curettage and CT scan of the clavicle which yielded pus that grew Pseudomonas aeruginosa. Following treatment with appropriate antibiotic therapy the patient presented a complete recovery of the lesion with no loss of renal function. This case highlights the importance of positive cultures in the choice of the appropriate therapy in an extremely rare case of an immunocompetent patient with osteomyelitis of the clavicle.

Investor-State Dispute Settlement under NAFTA Chapter 11: The Shape of Things to Come?

1998 ◽  
Vol 35 ◽  
pp. 263-290
Author(s):  
J. Anthony VanDuzer
Keyword(s):  
Free Trade Agreement ◽  
Dispute Settlement ◽  
Trade Agreement ◽  
Minimum Standards ◽  
The North ◽  
State Behaviour ◽  
Nafta Chapter 11 ◽  
To Come ◽  
The Right

SummaryRecently, there has been a proliferation of international agreements imposing minimum standards on states in respect of their treatment of foreign investors and allowing investors to initiate dispute settlement proceedings where a state violates these standards. Of greatest significance to Canada is Chapter 11 of the North American Free Trade Agreement, which provides both standards for state behaviour and the right to initiate binding arbitration. Since 1996, four cases have been brought under Chapter 11. This note describes the Chapter 11 process and suggests some of the issues that may arise as it is increasingly resorted to by investors.

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