scholarly journals Renal bone disease in pediatric and young adult patients on hemodialysis in a children's hospital.

1993 ◽  
Vol 3 (12) ◽  
pp. 1938-1946
Author(s):  
R Mathias ◽  
I Salusky ◽  
W Harman ◽  
A Paredes ◽  
J Emans ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Serum Calcium ◽  
Bone Disease ◽  
Adult Patients ◽  
Osteitis Fibrosa ◽  
Assay Method ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Renal Bone Disease ◽  
Serum Pth

Renal bone disease has been well defined in adult patients receiving chronic dialysis and in children on peritoneal dialysis/continuous ambulatory peritoneal dialysis. However, little is known about the histologic features in patients undergoing chronic hemodialysis in a children's hospital center. Twenty one patients, aged 17.5 +/- 1.5 yr, on hemodialysis for 35 +/- 6 months underwent iliac crest bone biopsies and deferoxamine infusion tests. Nineteen of 21 patients were receiving oral calcitriol. The 21 patients were classified by histomorphometry as follows: osteitis fibrosa, 5; mild hyperparathyroidism, 3; normal histology, 3; aplastic, 6; and mixed lesions, 4. Four of 21 patients were surface positive for aluminum, and seven other patients stained positive for iron in bone. Serum parathyroid hormone (PTH) levels correlated directly with the bone formation rate (r = 0.84) and with eroded bone perimeter (r = 0.67). Eight of the nine patients with serum PTH levels above 125 pg/mL had marrow fibrosis. All patients with serum calcium levels < 10.0 mg/dL and serum PTH levels > 125 pg/mL had either osteitis fibrosa or mixed bone lesions--a group of patients that might benefit from aggressive vitamin D therapy. In contrast, an examination of patients with serum calcium levels > 10.0 mg/dL and serum PTH levels < 65 pg/mL correctly identified three out of three patients with aluminum-related bone disease. These findings suggest that measurements of serum intact PTH levels by the immunoradiometric assay method may be valuable in distinguishing high-turnover lesions from normal or low-turnover skeletal lesions in this population.

Fatal Chloroquine Poisoning in a Child: Experience With Peritoneal Dialysis

PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 536-538
Author(s):  
William P. McCann ◽  
Robert Permisohn ◽  
P. A. Palmisano
Keyword(s):  
Peritoneal Dialysis ◽  
Case Report ◽  
The Body ◽  
Chloroquine Overdose ◽  
Children's Hospital ◽  
Chloroquine Poisoning ◽  
Child Experience ◽  
Children’S Hospital ◽  
Chloroquine Diphosphate ◽  
Black Boy

Chloroquine overdose is commonly fatal in children.1 We report here such a case in which peritoneal dialysis was tried. Analyses of tissues, serum, urine, and dialysate for chloroquine confirmed the diagnosis and indicated that little of this drug was removed from the body by dialysis. CASE REPORT A healthy 28-month-old black boy weighing 17.17 kg was seen holding two 500-mg chloroquine diphosphate (Aralen) tablets from a relative's purse about 3:30 PM one afternoon. One-half hour later he was found unconscious and was brought to the Children's Hospital, arriving at 5 PM apneic and with fixed, dilated pupils. It was stated that breathing stopped just before arrival.

Wilms tumor outcome and biology in adolescent and young adult patients at Ann and Robert H. Lurie Children's Hospital of Chicago.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e21016-e21016
Author(s):  
Christine Higham ◽  
Yasmin C. Gosiengfiao ◽  
David Otto Walterhouse ◽  
Elaine Morgan ◽  
Jennifer Reichek ◽  
...  
Keyword(s):  
Young Adult ◽  
Wilms Tumor ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Children's Hospital ◽  
Children’S Hospital

Mo1964 Efficacy and Safety of Endoscopic Studies in 207 Pediatric and Young Adult Patients: A Japanese Single Children's Hospital Experience

2012 ◽  
Vol 142 (5) ◽  
pp. S-709
Author(s):  
Kie Nakao ◽  
Kouji Kawamoto ◽  
Yuri Etani ◽  
Yoshiko Nakayama ◽  
Akio Kubota ◽  
...  
Keyword(s):  
Young Adult ◽  
Adult Patients ◽  
Efficacy And Safety ◽  
Children's Hospital ◽  
Hospital Experience ◽  
Children’S Hospital

scholarly journals Outcome of acute peritoneal dialysis (APD) in renal failure among children admitted at Children’s Hospital and Institute of Child Health, Multan.

2020 ◽  
Vol 27 (08) ◽  
pp. 1560-1564
Author(s):  
Shahid Ishaq ◽  
Saima Jabeen Joiya ◽  
Muhammad Azam Khan
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis ◽  
Child Health ◽  
Case Series ◽  
Mortality And Morbidity ◽  
Children's Hospital ◽  
Case Series Study ◽  
Children’S Hospital ◽  
Series Study

Objectives: Renal failure (RF) is associated with significant mortality and morbidity. its management still remains challenging for treating physicians. Acute peritoneal dialysis (APD) is an option for treatment of renal failure among young children. We aimed to determine the efficacy of peritoneal dialysis (PD) in RF among children admitted. Study Design: Case series study. Setting: Nephrology Department of Children’s Hospital and Institute of Child Health, Multan. Period: February 2018 to July 2018. Material & Methods: A total of 74 children with renal failure were included. All the patients were treated with acute peritoneal dialysis. The outcome of interest was clinical and biochemical improvement. Result: Amongst all there were 46 (62.2%) male and 26 (37.8%) female. Mean age of the children was found to be 57.72 months. Mean weight of children was 12.36 kg with a standard deviation of 6.4 kg. Most of the children, 43 (58.1%) had acute renal failure (ARF) whereas 31 (41.9%) had chronic renal failure (CRF). With PD, mortality was reported in 22 (29.7%) children. Conclusion: Acute peritoneal dialysis showed good rates of improvement in renal function, so, it should be recommending among children with acute renal failure.

scholarly journals Limited Additive Diagnostic Impact of Isolated Gastrointestinal Involvement for the Triage of Children with Suspected COVID-19

Children ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 41
Author(s):  
Désirée Caselli ◽  
Claudio Cafagno ◽  
Daniela Loconsole ◽  
Annamaria Giannini ◽  
Francesco Tansella ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Gastrointestinal Symptoms ◽  
Adult Patients ◽  
Time Interval ◽  
Gastrointestinal Involvement ◽  
Diagnostic Impact ◽  
Children's Hospital ◽  
Optimal Separation ◽  
Gi Symptoms ◽  
Children’S Hospital

The strategy for the selection of patients with a suspected SARS-CoV-2 infection is relevant for the organization of a children’s hospital to provide optimal separation into COVID-19 and non-COVID-19 areas and pathways. We analyzed the proportion of children with COVID-19 presenting with gastrointestinal (GI) symptoms in 137 consecutive patients admitted between January 2020 and August 2021. GI symptoms were present as follows: diarrhea in 35 patients (26%), vomiting in 16 (12%), and both of them in five (3%); the combination of fever, respiratory symptoms, and diarrhea was observed in 16 patients (12%). Of the 676 adult patients with COVID-19 admitted to our hospital in the same time interval, 62 (9.2%) had diarrhea, 30 (4.4%) had vomiting, and 11 (1.6%) had nausea; only one patient, a 38-year-old male, presented with isolated GI symptoms at the diagnosis. Although diarrhea was observed in one quarter of cases, one-half of them had the complete triad of fever, respiratory syndrome, and diarrhea, and only five had isolated diarrhea, of which two were diagnosed with a Campylobacter infection. The occurrence of either respiratory symptoms or gastrointestinal symptoms in our patients was not related to the patient age, while younger children were more likely to have a fever. Of the 137 patients, 73 (53%) could be tested for their serum level of SARS-CoV-2 specific IgG antibodies. The observed titer ranged between 0 (n = 3) and 1729 BAU/mL (median, 425 BAU/mL). Of 137 consecutive patients with COVID-19 admitted to our referral children’s hospital, only three presented with an isolated GI manifestation. It is interesting to note that this finding turned out to be fully in keeping with what was observed on adult patients with COVID-19 in our hospital. The additive diagnostic impact of gastrointestinal involvement for the triage of children with suspected COVID-19 appears limited.

scholarly journals Retrospective Review of Pediatric and Adult Autoimmune Hepatitis in Two Quaternary Care Centres in British Columbia: Increased Prevalence Seen in British Columbia’S First Nations Community

2007 ◽  
Vol 21 (9) ◽  
pp. 565-568 ◽  
Author(s):  
Henry V Chung ◽  
Mark Riley ◽  
Jin K Ho ◽  
Benjamin Leung ◽  
Gareth P Jevon ◽  
...  
Keyword(s):  
British Columbia ◽  
Liver Transplant ◽  
Autoimmune Hepatitis ◽  
First Nations ◽  
Adult Patients ◽  
Children's Hospital ◽  
Transplant Program ◽  
Increased Risk ◽  
Children’S Hospital ◽  
Nations Community

BACKGROUND: It has been previously reported that British Columbia’s (BC’s) First Nations (Aboriginal) community has an increased risk of autoimmune diseases, including rheumatological conditions (rheumatoid arthritis, systemic lupus) and primary biliary cirrhosis. The researchers hypothesized that this community may also be at increased risk for autoimmune hepatitis (AIH).METHODS: Independent, retrospective reviews of the databases of two separate tertiary/quaternary British Columbia university-affiliated health care institutions, the Adult Liver Transplant Program of the BC Transplant Society and the Division of Pediatric Gastroenterology, BC Children’s Hospital (Vancouver, BC), were performed. All patients referred with a diagnosis of probable or definite AIH who identified themselves as being of First Nations descent from 1988 to 2004 were reviewed. The liver transplant database records all adult patients in the province referred for transplant assessment. The pediatric database records all children referred to the BC Children’s Hospital.RESULTS: A total of 68 adult patients with a definite or probable diagnosis of AIH were referred to the liver transplant program. Twelve patients (17.6%) were Aboriginal, 11 of which were female. Similarly, a total of 30 children with probable or definite AIH were identified from the pediatric database. Six of these cases (20%) were identified in Aboriginal children.CONCLUSIONS: The findings suggest an increased prevalence of AIH among BC’s First Nations community. A disproportionate First Nations representation was found on independent review of two databases. Future studies are needed to determine the true prevalence of AIH in this community, and to uncover the genetic predisposition and the environmental triggers explaining this phenomenon.

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