Fatal Chloroquine Poisoning in a Child: Experience With Peritoneal Dialysis

PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 536-538
Author(s):  
William P. McCann ◽  
Robert Permisohn ◽  
P. A. Palmisano

Chloroquine overdose is commonly fatal in children.1 We report here such a case in which peritoneal dialysis was tried. Analyses of tissues, serum, urine, and dialysate for chloroquine confirmed the diagnosis and indicated that little of this drug was removed from the body by dialysis. CASE REPORT A healthy 28-month-old black boy weighing 17.17 kg was seen holding two 500-mg chloroquine diphosphate (Aralen) tablets from a relative's purse about 3:30 PM one afternoon. One-half hour later he was found unconscious and was brought to the Children's Hospital, arriving at 5 PM apneic and with fixed, dilated pupils. It was stated that breathing stopped just before arrival.

2019 ◽  
Author(s):  
Martin Greta

BACKGROUND Tuberculosis is a widespread and in many cases a fatal, infectious disease caused by many strains of mycobacterium complex usually mycobacterium tuberculosis. It can affect any part of the body but mainly the lungs hence called pulmonary tuberculosis. Tuberculosis in children has been less of a public health priority in the recent years despite the fact that TB has been a major cause of childhood morbidity and mortality worldwide with difficulties in diagnosis. Data on trends of childhood TB is rarely in published literature hence need for this research which will help in publishing OBJECTIVE To establish the trends in TB among children aged 1-12 years and its management over a period of five years from 2011- 2015 at Arthur Davison children’s hospital in Ndola and also to determine the proportion of TB in these children and to establish the age group most affected by TB over the period of five years and lastly to assess the proportion of TB and HIV as a co-morbidity METHODS The study reviewed all records that were registered in the MOH TB register at ADH from 2011 to 2015 coming up with a total number of 483 TB records and these records had satisfied the inclusion and exclusion criteria. The data capturing tool was used to collect the data. RESULTS : This study determined the trends of TB in children aged 1 to 12 over the five years period from a total of 483 reviewed paediatric TB cases , its proportion in these children, the age range most affected by TB and lastly assessed TB and HIV as a co-morbidity at Arthur Davison Children’s hospital. It revealed that the trends were decreasing and that out of 483 TB patient, the majority 157(32.5%) of the TB patients were seen in the year 2011, followed by 129(26.7%), 84(17.4%), 57(11.8%) and 56(11.6%) representing the year 2012, 2013, 2014 and 2015 respectively. Findings on the age range most affected are that the majority 282(58.4%) of the TB patients were aged (5-12) years old while 201(41.6%) were aged between (1-5) years old. Therefore, the age range most affected by TB was between (5-12) years. The TB proportion results showed that Out of 483, the majority 467(96.7%) of the TB patient type were newly diagnosed, followed by 13(2.7%), 2(.4%) and the rest 1(.2%) that were Relapse, Trans-in and Treatment resumed respectively. And that many 467(96.7%) of TB condition types were PTB while 16(3.3%) were EPTB. Furthermore, the majority of 463(95.9%) were diagnosed by X-ray while 20(4.1%) were diagnosed by smear microscopy. And lastly In terms of HIV as a co-morbidity, the majority 175(36.2%) of the TB patients were HIV positive, followed by 173(35.8%) that were HIV negative while the rest 135(28%) of the TB patients were not tested for HIV CONCLUSIONS This study reports that the trends of TB in children aged 1-12 years have been decreasing from 2015 to 2011 .And the age range most affected was found to have been 5-12 years and the proportion of TB cases were mostly newly diagnosed and the diagnosis was made by use x-ray and lastly the large proportion of TB patients had tested positive for HIV as a co-morbidity. Therefore efforts should be made to sustain this decreasing trend of childhood TB.


Author(s):  
Hailey Martin ◽  
Peter Akpunonu

Background: A Gar is a primarily freshwater fish that resides in North America. The flesh of a garfish is edible; however, the eggs and any meat surrounding the eggs are highly toxic to humans. The toxicity is induced by the protein ichthyotoxin. Case Report: The studied patient was an 18-year-old male who ingested 2-3 spoons full of gar eggs in their residence place. Each spoon full contained 40-50 eggs. The estimated total amount of consumed eggs equaled 3 teaspoons. Approximately one hour after eating the eggs, the patient began to feel unwell. Upon arrival at the local Children’s Hospital, the patient was experiencing nausea, vomiting, diarrhea, and sweating. Conclusion: Patients affected by gar eggs should be treated symptomatically, given there is no antidote or specific treatment for ichthyotoxin. Further research is required on the mechanism that makes ichthyotoxin toxic. Luckily, the presented patient presented no seizures due to the toxin and the care providers could manage the related symptoms.


2017 ◽  
Vol 2 (5) ◽  
Author(s):  
Fernando Cal Garcia Filho ◽  
Breno Leite Luz ◽  
Mateus de Oliveira Trindade ◽  
Lucas Cortizo Garcia ◽  
Magda Leão Pinheiro ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
pp. 168-169
Author(s):  
M. Khalili ◽  
M. Gholamzadeh Baeis ◽  
M. Alaei

A 10-year-old boy known case of Gaucher disease about 2 years ago was admitted with nausea, vomiting and epigastric pain from 3 days before hospitalization to Mofid Children’s hospital, Tehran, Iran. On the initial examination, no abnormalities were found except for splenomegaly and brief tenderness on the spleen. In secondary paraclinical evaluations (with Ultrasound and Ct-scan), we noticed mesenteric lymphadenopathy in the patient. The lesions remained unchanged and no significant changes were observed in the clinical and laboratory evaluations of the patient during one-year follow-up period. This is a rare and benign manifestation of Gaucher disease, which is usually monitored and does not require any intervention without signs of malignancy or severe space occupying effects 


1993 ◽  
Vol 3 (12) ◽  
pp. 1938-1946
Author(s):  
R Mathias ◽  
I Salusky ◽  
W Harman ◽  
A Paredes ◽  
J Emans ◽  
...  

Renal bone disease has been well defined in adult patients receiving chronic dialysis and in children on peritoneal dialysis/continuous ambulatory peritoneal dialysis. However, little is known about the histologic features in patients undergoing chronic hemodialysis in a children's hospital center. Twenty one patients, aged 17.5 +/- 1.5 yr, on hemodialysis for 35 +/- 6 months underwent iliac crest bone biopsies and deferoxamine infusion tests. Nineteen of 21 patients were receiving oral calcitriol. The 21 patients were classified by histomorphometry as follows: osteitis fibrosa, 5; mild hyperparathyroidism, 3; normal histology, 3; aplastic, 6; and mixed lesions, 4. Four of 21 patients were surface positive for aluminum, and seven other patients stained positive for iron in bone. Serum parathyroid hormone (PTH) levels correlated directly with the bone formation rate (r = 0.84) and with eroded bone perimeter (r = 0.67). Eight of the nine patients with serum PTH levels above 125 pg/mL had marrow fibrosis. All patients with serum calcium levels < 10.0 mg/dL and serum PTH levels > 125 pg/mL had either osteitis fibrosa or mixed bone lesions--a group of patients that might benefit from aggressive vitamin D therapy. In contrast, an examination of patients with serum calcium levels > 10.0 mg/dL and serum PTH levels < 65 pg/mL correctly identified three out of three patients with aluminum-related bone disease. These findings suggest that measurements of serum intact PTH levels by the immunoradiometric assay method may be valuable in distinguishing high-turnover lesions from normal or low-turnover skeletal lesions in this population.


PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 437-438
Author(s):  
Leslie L. Barton ◽  
Larry K. Pickering

The diagnosis of shigellosis is only rarely considered in the infant whose diarrhea commences during the first week of life. Haltalin1 reported six cases and reviewed seven others that had appeared in the literature up until 1967. Three other cases have been reported.2-4 We would like to describe an additional infant with onset of diarrhea due to Shigella flexneri infection on her second day of life. Case Report Patient C.E. (SLCH #72-6528) was admitted to St. Louis Children's Hospital at 36 hours of age with fever and bloody diarrhea. The mother had a third trimester urinary tract infection treated with parenteral ampicillin. No diarrhea was noted during her pregnancy.


PEDIATRICS ◽  
1965 ◽  
Vol 35 (2) ◽  
pp. 342-344
Author(s):  
KENNETH G. JAMIESON

An intranasal glioma presenting at birth as a readily visible polyp without any evidence of nasal deformity is an uncommon lesion. The purpose of this report is to record one such case in which the site of attachment of the glioma to the brain was studied at operation. Case Report On the day after his birth, August 26, 1958, a boy (A.R.) was referred to the Brisbane Children's Hospital with a provisional diagnosis of nasal encephalocoele. A reddish fleshy lump was to be seen just within the left nostril. There was no other evidence of nasal abnormality, and, in particular, the nasal bridge was normal.


Foot & Ankle ◽  
1980 ◽  
Vol 1 (2) ◽  
pp. 74-77 ◽  
Author(s):  
R. M. Letts ◽  
D. Gibeault

A review of children with talar injuries treated at the Winnipeg Children's Hospital yielded 12 patients that had been treated for fractures of the neck of the talus between 1960 and 1978, inclusive. Three developed avascular necrosis of the body of the talus; two of these had their fractures recognized only after avascular necrosis had become radiologically evident. The children ranged in age from 1 year 7 months to 13 years 11 months at the time of the injury. Fracture of the neck of the talus does occur in children and may be associated with avascular necrosis of the body. This injury should be considered and the talus should be examined in all children sustaining trauma secondary to falls from a height or motor vehicle trauma.


2020 ◽  
Vol 27 (08) ◽  
pp. 1560-1564
Author(s):  
Shahid Ishaq ◽  
Saima Jabeen Joiya ◽  
Muhammad Azam Khan

Objectives: Renal failure (RF) is associated with significant mortality and morbidity. its management still remains challenging for treating physicians. Acute peritoneal dialysis (APD) is an option for treatment of renal failure among young children. We aimed to determine the efficacy of peritoneal dialysis (PD) in RF among children admitted. Study Design: Case series study. Setting: Nephrology Department of Children’s Hospital and Institute of Child Health, Multan. Period: February 2018 to July 2018. Material & Methods: A total of 74 children with renal failure were included. All the patients were treated with acute peritoneal dialysis. The outcome of interest was clinical and biochemical improvement. Result: Amongst all there were 46 (62.2%) male and 26 (37.8%) female. Mean age of the children was found to be 57.72 months. Mean weight of children was 12.36 kg with a standard deviation of 6.4 kg. Most of the children, 43 (58.1%) had acute renal failure (ARF) whereas 31 (41.9%) had chronic renal failure (CRF). With PD, mortality was reported in 22 (29.7%) children. Conclusion: Acute peritoneal dialysis showed good rates of improvement in renal function, so, it should be recommending among children with acute renal failure.


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