Serum Th17 and TNF-α distinguish between patients with occult hepatitis B infection, chronic hepatitis B infection and healthy individuals

2021 ◽  
Vol 32 (2) ◽  
pp. 23-30
Author(s):  
Francisca Sosa-Jurado ◽  
Laura Sánchez-Reza ◽  
Miguel Ángel Mendoza-Torres ◽  
Daniel Meléndez-Mena ◽  
Víctor Hugo García y García ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Infection ◽  
Healthy Individuals ◽  
Chronic Hepatitis B Infection ◽  
Occult Hepatitis ◽  
Tnf Α ◽  
Occult Hepatitis B

Current Knowledge of Occult Hepatitis B Infection and Clinical Implications

2019 ◽  
Vol 39 (02) ◽  
pp. 249-260 ◽  
Author(s):  
Terry Yip ◽  
Grace Wong
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Clinical Course ◽  
Hbv Dna ◽  
Clinical Implications ◽  
Hepatitis B Infection ◽  
Occult Hepatitis ◽  
Hbsag Seroclearance ◽  
Occult Hepatitis B

AbstractOccult hepatitis B infection (OBI) is a status of undetectable serum hepatitis B surface antigen (HBsAg) yet detectable serum and/or intrahepatic hepatitis B virus (HBV) DNA. Mutations in the preS1, preS2, and S regions of the HBsAg gene may result in undetectable HBsAg. OBI may either result from a self-limiting acute hepatitis, or in patients with chronic hepatitis B who achieved HBsAg seroclearance, which refers to the loss of detectability of serum HBsAg with or without antibody to HBsAg (anti-HBs) in chronic hepatitis B (CHB) patients. HBsAg seroclearance contributes to a significant proportion of population in seropositive OBI. Both spontaneous and antiviral treatment-induced HBsAg seroclearance rarely happens; yet both types of HBsAg seroclearance are durable. CHB patients who achieve HBsAg seroclearance generally have a favorable clinical course. There is still a low yet definite risk of HCC occurrence, particularly in male CHB patients who achieve HBsAg seroclearance after being 50 years old. Clinical implications of OBI include occurrence of cirrhosis and HCC, liver transplantation, blood products transfusion, hemodialysis, and so on. A potentially life-threatening condition would be OBI reactivation in patients during immunosuppression therapy, especially in the setting of intensified immunosuppression including in onco-hematological patients (those receiving hematopoietic stem cell transplantation and treated with the anti-CD20 monoclonal antibody [e.g., rituximab]). With more new insights into these two conditions, CHB patients who achieved HBsAg seroclearance generally have benign clinical course and good prognosis. Sensitive assay for serum HBV DNA should be considered to establish the presence of OBI in the clinical settings mentioned earlier, which will affect the management plan.

scholarly journals Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population

Gut ◽  
2010 ◽  
Vol 59 (10) ◽  
pp. 1389-1393 ◽  
Author(s):  
M.-F. Yuen ◽  
C.-K. Lee ◽  
D. K.-H. Wong ◽  
J. Fung ◽  
I. Hung ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Blood Donor ◽  
Endemic Area ◽  
Hepatitis B Infection ◽  
Occult Hepatitis ◽  
Occult Hepatitis B ◽  
Donor Population

Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection

1997 ◽  
Vol 12 (9-10) ◽  
pp. S354-S369 ◽  
Author(s):  
JR WANDS ◽  
M GEISSLER ◽  
JZU PUTLITZ ◽  
H BLUM ◽  
F WEIZSÄCKER ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Chronic Hepatitis ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Infection ◽  
Chronic Hepatitis B Infection

scholarly journals Spontaneous HBsAg seroconversion after severe flare of chronic hepatitis B infection

2010 ◽  
Vol 9 (2) ◽  
pp. 194-197 ◽  
Author(s):  
Akif Altinbaş ◽  
llhami Yüksel ◽  
Melih Pamukcu ◽  
Fuat Ekiz ◽  
Ömer Başar ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Infection ◽  
Chronic Hepatitis B Infection ◽  
Hbsag Seroconversion
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