Evaluation of measurement uncertainty at establishing metrological traceability of results of clinical studies of biological samples

2020 ◽  
Vol 9 (3) ◽  
pp. 32
Author(s):  
A.G. Chunovkina
Keyword(s):  
Measurement Uncertainty ◽  
Biological Samples ◽  
Clinical Studies ◽  
Metrological Traceability

scholarly journals Identification of Serogroups Australis and Icterohaemorrhagiae in Two Dogs with a Severe Form of Acute Leptospirosis in Italy

Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 351 ◽  
Author(s):  
Andrea Balboni ◽  
Silvia Zamagni ◽  
Cristina Bertasio ◽  
Maria Beatrice Boniotti ◽  
Roberta Troìa ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Molecular Analysis ◽  
Biological Samples ◽  
Clinical Studies ◽  
Clinical Presentation ◽  
Severe Form ◽  
Sequence Type ◽  
Serious Illness ◽  
Severe Clinical Presentation ◽  
Leptospira Spp

Leptospirosis is an infectious disease that causes serious illness in dogs. For this reason, epidemiological and clinical studies focusing on disease characterization are widely advocated. The aim of this study was to characterize the leptospires identified in dogs with confirmed symptomatic acute leptospirosis. Leptospira spp. DNA detected in urine, blood, or both samples from nine infected dogs was analyzed using the multi-locus sequence typing (MLST) technique. Leptospires from two dogs were successfully typed: one was identified as belonging to Sequence Type (ST) 17 and one to ST198, both within the L. interrogans species, serogroups Icterohaemorrhagiae and Australis, respectively. Based on the results of routine serologic tests, antibodies reactive toward these serogroups are commonly revealed in dogs in Italy. This study provides the first molecular analysis that identifies infecting Leptospira directly on DNA from biological samples of dogs, showing that serogroup Australis can lead to a severe clinical presentation of leptospirosis in infected dogs.

scholarly journals AC/DC transfer standards calibration in Central Military Calibration Laboratory

2017 ◽  
Vol 66 (4) ◽  
pp. 217-228
Author(s):  
Przemysław Piróg ◽  
Mariusz Górecki
Keyword(s):  
Measurement Uncertainty ◽  
Metrological Traceability ◽  
Uncertainty Budget ◽  
Voltage Measurement ◽  
Measurement Equation ◽  
Calibration Laboratory ◽  
Transfer Standard ◽  
Thermal Voltage

The article discusses the method used in the Central Military Calibration Laboratory to calibrate Fluke 5790 AC/DC transfer standard with reference transfer standard Fluke 792A. It presents the measurement equation and the uncertainty budget. The contribution of uncertainty components in the measurement uncertainty has been presented. The metrological traceability has been evaluated by comparing calibration results with the results in the last Fluke certificate of calibration. Keywords: AC/DC converters, AC/DC difference, thermal voltage converters (TVCs), AC voltage measurement.

THE INTERACTION OF PROCESSES OF TESTING LABORATORY MANAGEMENT SYSTEM ACCORDING TO THE GOST ISO/IEC 17025-2019 REQUIREMENTS

2020 ◽  
pp. 107-112
Author(s):  
S.S.S. AL-BUSAIDI ◽  
◽  
S.V. PONOMAREV ◽  
Keyword(s):  
Measurement Uncertainty ◽  
Management System ◽  
Metrological Traceability ◽  
Verification And Validation ◽  
Main Process ◽  
Laboratory Management ◽  
Testing Laboratory ◽  
Validity Of Results ◽  
Management Review ◽  
Execution Order

The execution order of the processes of the management system (MS) of the testing laboratory (TL), certified according to the requirements of the standard GOST ISO / IEC 17025-2019, is discussed. It was established that the process “8.9 Management Review” is the main process in managing activities in a testing laboratory. The interaction of this process with other MS TL processes is considered, in particular: “6.2 Personnel”, “6.4 Equipment”, “6.5 Metrological traceability”, “7.2 Selection, verification and validation of methods”, “7.6 Evaluation of measurement uncertainty”, “7.7 Ensuring the validity of results”, “7.10 Management of inappropriate work”, “8.5 Actions related to risks and opportunities”, “8.6 Improvement”, “8.7 Corrective actions”, “ 8.8. Internal Audits”, etc.

scholarly journals Application of systems thinking to the establishment of metrological traceability chains

2021 ◽  
pp. 3-7
Author(s):  
Oleh Velychko ◽  
Tetyana Gordiyenko
Keyword(s):  
Measurement Uncertainty ◽  
Systems Thinking ◽  
Metrological Traceability ◽  
Measuring Instruments ◽  
Measurement Standard ◽  
International Laboratory Accreditation Cooperation ◽  
Traceability Chain ◽  
Measurement Standards ◽  
Calibration Laboratories ◽  
Different Levels

International agreements in the field of metrology and accreditation of calibration laboratories are the basis for establishing global metrological traceability. Important elements of metrological traceability are calibration of measurement standards and measuring instruments, assessment of measurement uncertainty. The International Laboratory Accreditation Cooperation has a specific policy regarding on traceability of measurement results and estimation of measurement uncertainty in calibration. The partial concept diagram around metrological traceability in accordance with the International Vocabulary of Metrology is proposed. This diagram contains a total of nine metrological concepts, which have most of the associative relations. There are associative relations between the concept of metrological traceability chain and concepts of metrological traceability, measurement standard, calibration and calibration hierarchy, and through the concept of measurement standard with the concept of measurement uncertainty. Systems thinking to the analysis of state of proposed terminological system around metrological traceability was applied. For construction of generalized metrological traceability chain, all the established properties of the system elements around the terminology system of metrological traceability were taken into account. Generalized metrological traceability chain for different levels of the calibration hierarchy was proposed. The proposed chain can be used to develop appropriate chains for specific areas of measurement. To achieve this, it is necessary to determine the specific measured value, the required measurement uncertainty for different levels of the calibration hierarchy and select the necessary measurement standards. Such schemes should be used in national metrology institutes and calibration laboratories.

Mass and volume in analytical chemistry (IUPAC Technical Report)

2018 ◽  
Vol 90 (3) ◽  
pp. 563-603 ◽  
Author(s):  
Maria F. Camões ◽  
Gary D. Christian ◽  
David Brynn Hibbert
Keyword(s):  
Analytical Chemistry ◽  
Quality Assurance ◽  
Measurement Uncertainty ◽  
Mass Measurement ◽  
Metrological Traceability ◽  
Amount Of Substance ◽  
Technical Report

Abstract This technical report reviews measurements of mass and volume, including a review of the SI for mass, length, and amount of substance; principles of mass measurement; calibration of masses and glassware; gravimetry; volumetry; and titrimetry. Measurement uncertainty, metrological traceability and aspects of quality assurance are also treated.

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