One-stage operations in patients having colorectal cancer with synchronous multiple liver metastases

2017 ◽  
Vol 6 (6) ◽  
pp. 21
Author(s):  
S. V. Kozlov ◽  
O. I. Kaganov ◽  
A. E. Orlov ◽  
A. M. Kozlov
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
One Stage ◽  
Multiple Liver Metastases

scholarly journals STUDY OF THE POSSIBILITIES OF PREOPERATIVE CHEMOTHERAPY IN MULTIPLE METASTASIS OF COLORECTAL CANCER IN THE LIVER

2020 ◽  
Vol 1 (8(77)) ◽  
pp. 8-11
Author(s):  
Kh.D. Islamov ◽  
Sh.Kh. Niyozova
Keyword(s):  
Colorectal Cancer ◽  
Side Effects ◽  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
High Frequency ◽  
Partial Regression ◽  
Multiple Metastasis ◽  
Preoperative Ct ◽  
Multiple Liver Metastases ◽  
Surgical Operations

Preoperative chemotherapy (CT) in 35 patients with colorectal cancer (CRC) with liver metastases demonstrated a high frequency of objective effects - in 22 (62.9%) patients, stabilization was noted in 10 (28.6%) cases. With bilobar liver metastases and the use of oxaliplatin-containing regimens, partial regression was 62.9%. Side effects in most cases were clinically insignificant, no deaths were observed. The results obtained demonstrate the possibility of performing extended surgical operations in the majority of CRC patients with multiple liver metastases after preoperative CT.

scholarly journals Minimal Multiple Liver Metastases after Chemotherapy from Colorectal Cancer could be revealed with Intra Operative Ultrasonography using SONAZOIDTM

2011 ◽  
Vol 44 (4) ◽  
pp. 490-496
Author(s):  
Shigeru Ottomo ◽  
Toshiki Rikiyama ◽  
Shinichi Egawa ◽  
Yu Katayose ◽  
Fuyuhiko Motoi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multiple Liver Metastases

Impact of the Degree of Liver Resection on Survival for Patients with Multiple Liver Metastases from Colorectal Cancer

2008 ◽  
Vol 32 (9) ◽  
pp. 2057-2069 ◽  
Author(s):  
Kuniya Tanaka ◽  
Hiroshi Shimada ◽  
Chizuru Matsumoto ◽  
Kenichi Matsuo ◽  
Kazuhisa Takeda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Resection ◽  
Liver Metastases ◽  
Multiple Liver Metastases

scholarly journals Comparison of the clinicopathological characteristics and their impact on outcomes of resected colorectal liver metastases across time

2020 ◽  
Author(s):  
Lionel Chen ◽  
Nicholas L. Syn ◽  
Brian K. P. Goh ◽  
Peng Chung Cheow ◽  
Prema Raj ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Independent Predictor ◽  
Clinicopathological Characteristics ◽  
Nodal Metastases ◽  
Primary Colorectal Cancer ◽  
Poor Survival ◽  
Time Periods ◽  
Multiple Liver Metastases

Abstract Background Resection of colorectal liver metastases (CLM) has been established as the standard of care. This study aims to compare the change in clinicopathological characteristics of patients who underwent curative resection of CLM across two time periods – 2000 to 2010 (P1) and 2011 to 2016 (P2) and evaluate the prognostic impact of these characteristics on survival outcomes. Methods Patients who undergo liver resection for CLM at Singapore General Hospital from January 2000 to December 2016 were identified from a prospectively maintained database. The primary end point was overall survival. Results There were 183/318 (57.5%) patients and 135/318 (42.5%) patients in P1 and P2 respectively. There was a lower proportion of patients who had nodal metastases from primary colorectal cancer and clinical risk score (CRS) less than 3 in P2 when compared to P1. There was no difference in survival between both time periods. Independent predictors of survival for the cohort were CEA levels ≥200ng/ml, primary tumour grade and lymph nodal status. Independent predictors of poor survival in P1 were poorly differentiated colorectal cancer and nodal metastases while in P2, independent predictors of poor survival were multiple liver metastases and nodal metastases.Conclusion Nodal metastases from primary colorectal cancer is an independent predictor of poor survival across time for resectable CLM. Although there is no difference in survival between the two time periods, patients with multiple liver metastases should be carefully considered prior to surgery as it is also an independent predictor of overall survival.

scholarly journals Comparison of the clinicopathological characteristics and their impact on outcomes of resected colorectal liver metastases across time

2020 ◽  
Author(s):  
Lionel Chen ◽  
Nicholas L. Syn ◽  
Brian K. P. Goh ◽  
Peng Chung Cheow ◽  
Prema Raj ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Independent Predictor ◽  
Clinicopathological Characteristics ◽  
Nodal Metastases ◽  
Primary Colorectal Cancer ◽  
Poor Survival ◽  
Time Periods ◽  
Multiple Liver Metastases

Abstract Background Resection of colorectal liver metastases (CLM) has been established as the standard of care. This study aims to compare the change in clinicopathological characteristics of patients who underwent curative resection of CLM across two time periods – 2000 to 2010 (P1) and 2011 to 2016 (P2) and evaluate the prognostic impact of these characteristics on survival outcomes. Methods Patients who undergo liver resection for CLM at Singapore General Hospital from January 2000 to December 2016 were identified from a prospectively maintained database. The primary end point was overall survival. Results There were 183/318 (57.5%) patients and 135/318 (42.5%) patients in P1 and P2 respectively. There was a lower proportion of patients who had nodal metastases from primary colorectal cancer and clinical risk score (CRS) less than 3 in P2 when compared to P1. There was no difference in survival between both time periods. Independent predictors of survival for the cohort were CEA levels ≥200ng/ml, primary tumour grade and lymph nodal status. Independent predictors of poor survival in P1 were poorly differentiated colorectal cancer and nodal metastases while in P2, independent predictors of poor survival were multiple liver metastases and nodal metastases.Conclusion Nodal metastases from primary colorectal cancer is an independent predictor of poor survival across time for resectable CLM. Although there is no difference in survival between the two time periods, patients with multiple liver metastases should be carefully considered prior to surgery as it is also an independent predictor of overall survival.

Evaluation of Aggressively Treated Patients With Unresectable Multiple Liver Metastases From Colorectal Cancer

2002 ◽  
Vol 45 (11) ◽  
pp. 1503-1509 ◽  
Author(s):  
Nobutomo Miyanari ◽  
Takeo Mori ◽  
Keiichi Takahashi ◽  
Masamichi Yasuno
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multiple Liver Metastases

scholarly journals Comparison of the clinicopathological characteristics and their impact on outcomes of resected colorectal liver metastases across time

2020 ◽  
Author(s):  
Lionel Chen ◽  
Nicholas L. Syn ◽  
Brian K. P. Goh ◽  
Peng Chung Cheow ◽  
Prema Raj ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Independent Predictor ◽  
Clinicopathological Characteristics ◽  
Nodal Metastases ◽  
Primary Colorectal Cancer ◽  
Poor Survival ◽  
Time Periods ◽  
Multiple Liver Metastases

Abstract Background: Resection of colorectal liver metastases (CLM) has been established as the standard of care. This study aims to compare the change in clinicopathological characteristics of patients who underwent curative resection of CLM across two time periods – 2000 to 2010 (T1) and 2011 to 2016 (T2) and evaluate the prognostic impact of these characteristics on survival outcomes. Methods: Patients who undergo liver resection for CLM at Singapore General Hospital from January 2000 to December 2016 were identified from a prospectively maintained database. The primary end point was overall survival. ResultsThere were 183/318 (57.5%) patients and 135 /318 (42.5%) patients in T1 and T2 respectively. There was a lower proportion of patients who had nodal metastases from primary colorectal cancer and clinical risk score (CRS) less than 3 in T2 when compared to T1. There was no difference in survival between both time periods (HR 0.850 95% CI 0.601 – 1.201 p = 0.357). Independent predictors of survival for the cohort were CEA levels ≥200ng/ml, primary tumour grade and lymph nodal status. Independent predictors of poor survival in T1 were poorly differentiated colorectal cancer and nodal metastases while in T2, independent predictors of poor survival were multiple liver metastases and nodal metastases.Conclusion: Nodal metastases from primary colorectal cancer is an independent predictor of poor survival across time for resectable CLM. Although there is no difference in survival between the two time periods, patients with multiple liver metastases should be carefully considered prior to surgery as it is also an independent predictor of overall survival.

Abstract 4675: Effect and safety of FOLFOXIRI+B-mab as preoperative chemotherapy for multiple liver metastases of colorectal cancer.

2013 ◽  
Author(s):  
Yasushi Ichikawa ◽  
Ayumu Goto ◽  
Noriotoshi Kobayashi ◽  
Motohiko Tokuhisa ◽  
Takashi Ishikawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Multiple Liver Metastases

Effect and safety of FOLFOXIRI+b-mab as preoperative chemotherapy for multiple liver metastases of colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14047-e14047
Author(s):  
Yasushi Ichikawa ◽  
Ayumu Goto ◽  
Takeshi Shimamura ◽  
Takashi Ishikawa ◽  
Jun Watanabe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Phase I ◽  
Liver Metastases ◽  
Dose Escalation ◽  
Reduction Rate ◽  
Hematological Toxicity ◽  
R0 Resection ◽  
Resection Rate ◽  
Grade 3 ◽  
Multiple Liver Metastases

e14047 Background: R0 resection for liver metastases of colorectal cancer is one of the promising treatment to improve prognosis of advanced colorectal cancer. Recently, effective anti-cancer drugs and various regimens using them were created and some advanced inoperable liver metastases were converted to operable by these chemotherapy. Therefore, development of powerful regimens to shrink liver metastases strongly is an important issue. In our department phase I/II study of FOLFOXIRI+B-mab including fluoroiuracil/oxaliplatin/irinotecan/bevacizumab for advanced liver metastases of colorectal cancer as pre-operative chemotherapy has been conducted now. Methods: The study was designed as a single-arm, open-label phase I/II trial. Phase I was conducted as sequential dose escalation to define the maximum-tolerated dose (MTD) of irinotecan. Patients who are colorectal cancer with 4 or more liver metastases and no other distant metastases are included. The regimen includes bevacizumab; 5 mg/kg, oxaliplatin; 85 mg/m2, l-LV; 200 mg/m2, 5FU; 400 mg/m2 administered on day 1, followed by 5FU; 2400 mg/m2 continuously administered for 46 hours. Dose escalation of Irinotecan was planned from level 1; 150 mg/m2 , level 2; 180 mg/m2 and level 0; 125 mg/m2. In phase II, R0 resection rate of liver metastases as primary endpoint will be evaluated using MTD of irinotecan estimated in phase I. Results: Currently, 6 patients were studied. One patient showed grade 3 diarrhea as dose-limiting toxicity. For the other 5 patients, the study was accomplished. Grade 4 neutropenia was detected in 60%, however no patient showed febrile neutropenia. Excluding hematological toxicity, grade 3 or worse adverse event was only one grade 3 diarrhea described above. All 5 patients were performed R0 resection. All 5 patients showed PR and average of reduction rate was 62.7%. There was no pathological CR in the 5 patients who was performed R0 resection. There was no severe postoperative complication in them. Conclusions: This regimen is safe and shows high PR rate. So, the regimen is effective and improve R0 resection rate for multiple liver metastases of colorectal cancer. Further investigation of this study is still ongoing now.

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