Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-releasing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 µg/kg body weight, 3) GnRHa in 753-type microparticles at 50 µg/kg, or 4) GnRHa in 653-type microparticles at 50 µg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17β-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained – release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.

Download Full-text

Effects of intramuscular injections of vitamin E-selenium and a gonadotropin releasing hormone analogue (GnRHa) on reproductive performance and blood metabolites of post-molt male broiler breeders

Asian Pacific Journal of Reproduction ◽

10.1016/j.apjr.2016.01.013 ◽

2016 ◽

Vol 5 (2) ◽

pp. 156-160 ◽

Cited By ~ 3

Author(s):

Ahmad Hezarjaribi ◽

Vahid Rezaeipour ◽

Rohullah Abdollahpour

Keyword(s):

Vitamin E ◽

Reproductive Performance ◽

Gonadotropin Releasing Hormone ◽

Blood Metabolites ◽

Broiler Breeders ◽

Hormone Analogue ◽

Releasing Hormone ◽

Gonadotropin Releasing Hormone Analogue ◽

Intramuscular Injections

Download Full-text

An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

Porcine Health Management ◽

10.1186/s40813-016-0018-1 ◽

2016 ◽

Vol 2 (1) ◽

Cited By ~ 6

Author(s):

Frédéric Vangroenweghe ◽

Lieve Goossens ◽

Jan Jourquin

Keyword(s):

Birth Weight ◽

Reproductive Performance ◽

Gonadotropin Releasing Hormone ◽

Hormone Analogue ◽

Releasing Hormone ◽

Gonadotropin Releasing Hormone Analogue

Download Full-text

Spermatogenesis in photostimulated Red-winged Blackbirds (Agelaius phoeniceus) chronically treated with a potent gonadotropin releasing hormone analogue

Canadian Journal of Zoology ◽

10.1139/z90-352 ◽

1990 ◽

Vol 68 (12) ◽

pp. 2518-2523 ◽

Cited By ~ 3

Author(s):

Diane Lacombe ◽

André Cyr ◽

Pierre Matton

Keyword(s):

Gonadotropin Releasing Hormone ◽

Agelaius Phoeniceus ◽

Saline Control ◽

Seminiferous Tubules ◽

Control Group ◽

Hormone Analogue ◽

Releasing Hormone ◽

Testicular Growth ◽

Gonadotropin Releasing Hormone Analogue ◽

Dose Response Effect

To study the effect of a gonadotropin releasing hormone analogue (GnRH-A) on male Red-winged Blackbirds, birds received 13 (experiment 1) or 14 (experiment 2) consecutive daily injections of saline (control group) or GnRH-A during photoperiodically induced testicular growth. GnRH-A did not modify the diameter of the seminiferous tubules in treated groups compared with saline-injected controls. However, the thickness of the germinal epithelium was significantly reduced in groups receiving 0.1, 1.0, 10.0, or 20.0 μg of GnRH-A. Redwings showing disturbed spermatogenesis were significantly more frequent in the GnRH-A treated groups than in the control group. Moreover, there was a dose–response effect, since the proportion of redwings showing disturbed spermatogenesis increased with increasing doses of GnRH-A. Hyperplasia of the interstitial cells was frequent in GnRH-A treated birds compared with control birds, except for the group which received 0.01 μg of GnRH-A. These experiments show that chronic treatment with GnRH-A impairs spermatogenesis in Red-winged Blackbirds treated during testicular growth.

Download Full-text

Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0470 ◽

2021 ◽

Vol 34 (4) ◽

pp. 479-484

Author(s):

Piyathida Wijarn ◽

Preamrudee Poomthavorn ◽

Patcharin Khlairit ◽

Sarunyu Pongratanakul ◽

Laor Chailurkit ◽

...

Keyword(s):

Precocious Puberty ◽

Peptide Yy ◽

Central Precocious Puberty ◽

Gonadotropin Releasing Hormone ◽

Hormone Analogue ◽

Short Term ◽

Serum Leptin ◽

Releasing Hormone ◽

Gonadotropin Releasing Hormone Analogue ◽

Before And After

Abstract Objectives To determine appetite-regulating hormone levels in girls with central precocious puberty (CPP) before and after 20 weeks of gonadotropin-releasing hormone analogue (GnRH-A) treatment. Methods Eighteen newly diagnosed CPP girls were enrolled. Body composition measured by bioelectrical impedance analysis and GnRH-A test were performed with fasting serum leptin, ghrelin and peptide YY (PYY) measurements at baseline (before) and after 20 weeks of GnRH-A treatment. Results Following GnRH-A treatment, all patients had prepubertal gonadotropin and estradiol levels. Mean (SD) fat mass index (FMI) was significantly increased from 4.5 (1.7) to 5.0 (1.8) kg/m2 after treatment. Also, median (IQR) serum leptin level was significantly increased from 6.9 (4.2–8.6) to 7.4 (5.3–13.1) ng/mL. FMI had a positive correlation with serum leptin level (r=0.64, p=0.004). In contrast, no significant changes of serum ghrelin and PYY levels were observed. Conclusions Decreased estrogen following short-term GnRH-A treatment in CPP girls may cause an increase in appetite and consequently an elevation of FMI. Increased serum leptin may be a result of having increased FMI secondary to an increase in appetite.

Download Full-text