scholarly journals Evaluation of left ventricular hypertrophy in hypertensive patients with echocardiographic myocardial videodensitometry normalized by displacement

2010 ◽  
Vol 10 (4) ◽  
pp. 292-296 ◽  
Author(s):  
Xiao-Zhi Zheng ◽  
Lian-Fang Du ◽  
Hui-Ping Wang

Left ventricular hypertrophy (LVH) is an important predictor of cardiovascular morbidity and mortality. To investigate the feasibility of the myocardial grayscale intensity (GI) normalized by displacement (d) to discriminate between healthy and hypertrophic myocardium in hypertensive patients, sixty hypertensive patients and sixty age and sex-matched healthy volunteers were involved in this study. The peak d and the maximal GI [GI(max)] and minimal GI [GI(min)] for the middle interventricular septal (IVS) and the middle posterior wall (PW) at the level of papillary muscle were obtained from the standard parasternal long axis views using tissue tracking (TT) and videodensitometric analysis, respectively. The GI and the cyclic variation of GI (CVGI) normalized by d were calculated. The results showed that the d both for IVS and PW the amplitude of CVGI for IVS in hypertensive patients with LVH were smaller than the ones without LVH and the normal subjects. But, the CVGI/d both for IVS and PW in hypertensive patients with LVH were all greater than the ones without LVH and the normal subjects. Moreover, the parameter, CVGI/d correlated positively with left ventricular mass index (LVMI). So, the method employed in this study, videodensitometric analysis in combination with TT allow objective and accurate determination of LVH and CVGI/d is a sensitive indicator for hypertensive patients with LVH.

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Nelson Dinamarco ◽  
Marileide Dinamarco ◽  
Heitor Moreno

Introduction: Left ventricular hypertrophy (LVH) is an important cardiocerebrovascular risk factor and due to this fact, when present , in hypertensive patients should plan a more elaborate therapeutic treatment. The hsCRP is systemic inflammatory marker associated with increased risk of myocardial infarction and vascular diseases. Objective: Identify hsCRP as a strong biomarker with correlation with LVH in resistant hypertensive patients (RHTN). Methodology: A total of 180 patients: 60 RHTN and 60 RHTN with LVH with echocardiographic diagnosis (LVH-RHTN), compared to 60 normal subjects (control), with equal distribution of gender and age. The hs-CPR was measured using nephelometry method. Results: In LVH-RHTN hsCRP was 3.96 ± 1.11 mg/L and was significantly higher when compared with RHTN, which was 2.20 ± 0.53 mg/L, and with hsCRP 0.56 ± 0.23 in CON (p <0.001). There is a strong correlation between elevated hsCRP and LVH in patients with resistant hypertension, as shown by the Pearson coefficient (r = 0.74). Conclusion: hsCRP can be considered a strong predictor biomarker in presence of LVH in RHTN.


1982 ◽  
Vol 63 (s8) ◽  
pp. 379s-381s ◽  
Author(s):  
Luigi Corea ◽  
Maurizio Bentivoglio ◽  
Paolo Verdecchia ◽  
Mario Motolese

1. In 16 borderline and 18 sustained hypertensive patients, interventricular septal thicknesses (by echocardiography) were greater than those found in 18 healthy subjects. Values in borderline and sustained hypertensives did not differ significantly. 2. In healthy subjects and borderline hypertensive patients, posterior wall thicknesses were normal, whereas they were greater in sustained hypertensive patients than in the former two groups. 3. In borderline hypertension, interventricular septal thickness was positively correlated with resting supine (r = 0.89, P < 0.001) as well as upright (r = 0.60, P < 0.01) plasma noradrenaline, but not with adrenaline, plasma renin activity and mean blood pressure. 4. In sustained hypertension, posterior wall thickness was positively correlated with mean blood pressure (r = 0.85, P < 0.001), but not with noradrenaline, adrenaline and plasma renin activity. 5. In human hypertension, left ventricular hypertrophy seems to involve only the interventricular septum in the borderline stage, extending to the posterior wall in the sustained stage. Adrenergic overactivity could play an important role in development of interventricular septal hypertrophy in borderline hypertension, whereas pressor factors could be mainly involved in the development of posterior wall hypertrophy in sustained hypertension.


2008 ◽  
Vol 61 (3-4) ◽  
pp. 178-182 ◽  
Author(s):  
Marina Deljanin-Ilic ◽  
Stevan Ilic ◽  
Dragan Djordjevic ◽  
Marija Zdravkovic ◽  
Vladimir Ilic

Introduction Myocardial hypertrophy of the left ventricle may be of physiological or pathological nature. Distinction of these two types of hypertrophy is sometimes not easy and represents a diagnostic challenge. The aim of the study was to assess global diastolic and regional systolic and diastolic myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients. Material and methods In 18 male hypertensive patients and 14 male athletes global diastolic left ventriclar function and regional systolic and diastolic myocardial function of septum and posterior wall were investigated by pulsed wave tissue Doppler imaging. Results Ejection fraction and left ventricle mass index did not differ significantly between two groups. Hypertensive patients were found to have diastolic dysfunction while athletes had normal left ventricular diastolic function (the difference between the groups was P<0.00001). Index of regional diastolic function of septum as well as of the posterior wall was significantly less in hypertensive patients than in athletes (P<0.00001 for both). In spite of the normal global systolic function the regional systolic function of septum and posterior wall was significantly less in hypertensive patients than in athletes (P<0.02for both). Conclusion The present results show significantly less global and regional diastolic function of hypertrophied myocardium in hypertensive patients than in athletes. In the presence of preserved left ventricular systolic function, the quantification of myocardial velocity revealed significantly lower regional systolic function of septum and posterior wall in hypertensive patients than in athletes.


Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Pierre Boutouyrie ◽  
Stéphane Laurent ◽  
Xavier Girerd ◽  
Athanase Benetos ◽  
Patrick Lacolley ◽  
...  

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