scholarly journals Incidence of acute kidney injury in birth asphyxia and its correlation with severity of hypoxic ischemic encephalopathy (HIE) in newborns with perinatal asphyxia in SNCU at DR. BRAM Hospital, Raipur (CG)

2019 ◽  
Vol 6 (6) ◽  
pp. 304-309
Author(s):  
Dr. Sharja Phuljhele ◽  
◽  
Dr. Shashikant Dewangan ◽  
Dr. Yogita Rathi ◽  
◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals Study of incidence of acute kidney injury in asphyxiated neonates with hypoxic ischemic encephalopathy

2020 ◽  
Vol 7 (11) ◽  
pp. 2205
Author(s):  
Rita Chaudhary ◽  
Anil Kumar Tiwari ◽  
Farhan Usmani
Keyword(s):  
Acute Kidney Injury ◽  
Early Recognition ◽  
Perinatal Asphyxia ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Control Group ◽  
Medical College ◽  
Minute Apgar Score ◽  
Ischemic Encephalopathy ◽  
Control Study

Background: Perinatal asphyxia causes multi organ dysfunction resulting in renal (50%) and neurological (28%) compromise with 1.4% of hypoxic ischemic encephalopathy (HIE) and almost 20% death in India. Early recognition of acute kidney injury (AKI) is important in babies with HIE to facilitate appropriate fluid and electrolyte management for a stable biochemical milieu is vital.Methods: A prospective case control study was done in Patna Medical College and Hospital, Patna between January 2019 and March 2020. 70 term asphyxiated neonates with HIE as cases and 70 healthy neonates as control were taken. AKI on basis of p RIFLE criteria and HIE on the basis of 5 minute APGAR score were determined and correlated.Results: 58.6%cases of AKI with 73% pre renal and 61% non-oliguric type were found in asphyxiated neonates with HIE blood urea and serum creatinine values were significantly higher in asphyxiated babies than control group babies (p<0.0001).Conclusions: The extent of AKI is directly proportional to severity of HIE. 

scholarly journals Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 35 (3) ◽  
pp. 477-483 ◽  
Author(s):  
Francesco Cavallin ◽  
Giulia Rubin ◽  
Enrico Vidal ◽  
Elisa Cainelli ◽  
Luca Bonadies ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Prognostic Role ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ischemic Encephalopathy

scholarly journals Acute Kidney Injury (AKI) in perinatal asphyxia

2014 ◽  
Vol 2 (02) ◽  
pp. 60-65 ◽  
Author(s):  
Girish Gopal
Keyword(s):  
Acute Kidney Injury ◽  
Creatinine Clearance ◽  
Biochemical Parameters ◽  
Perinatal Asphyxia ◽  
Fluid Challenge ◽  
Kidney Injury ◽  
Renal Functions ◽  
Significant Difference ◽  
Urine Microscopy ◽  
Ischemic Encephalopathy

Background: Acute kidney injury (AKI) is a common consequence of perinatal asphyxia, occurring in upto 56% of these neonates. It is important to recognize AKI in asphyxiated neonates to facilitate administration of appropriate fluids and electrolytes in order to improve their outcome. Objectives: To determine the incidence of AKI in asphyxiated neonates and to correlate the severity and type of AKI with Apgar score and severity of hypoxic ischemic encephalopathy (HIE). Methods: 75 neonates were enrolled – 50 asphyxiated and 25 healthy neonates. Renal functions were assessed using urine output, urine microscopy, biochemical parameters and sonography. The values obtained were correlated with the severity of HIE. Neonates with AKI were managed as per unit protocol. Results: Of the 50 asphyxiated neonates, 32 (64%) had AKI: 25 (78.12 %) neonates with pre-renal AKI and the remaining 7 (21.88 %) with intrinsic AKI. Out of the 32 asphyxiated neonates with AKI, 12 (37.5%) had oliguric AKI, while the remaining 20 (62.5%) had non-oliguric AKI. Levels of blood urea and serum creatinine were significantly higher in asphyxiated neonates as compared to healthy controls (p 0.001). Biochemical derangements correlated well with the severity of HIE and Apgar scores. Serum sodium and creatinine clearance showed significantly different values in asphyxiated babies compared to controls. There was no significant difference in the urine ouput in the control and study group. Sonographic abnormalities were seen most often in oliguric babies, and indicated bad prognosis. Mortality was higher in babies with oliguric AKI. Conclusions: Perinatal asphyxia is an important cause of neonatal AKI. Majority of the babies had non-oliguric AKI and responded well to fluid challenge. Abnormalities in the renal function correlates well with the severity of HIE. Intrinsic AKI, oliguria, hyponatremia, reduced creatinine clearance and abnormal sonographic scan suggest bad prognosis in neonatal AKI secondary to perinatal asphyxia.

scholarly journals Correlation of serum creatinine kinase muscle-brain fraction and lactate dehydrogenase with severity of hypoxic ischemic encephalopathy in perinatal asphyxia in term neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 405
Author(s):  
Masaraddi Sanjay K. ◽  
Ahamed Roshan P. M. ◽  
Nedunchezhian P. ◽  
Sulekha C.
Keyword(s):  
Lactate Dehydrogenase ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Term Neonate ◽  
Creatinine Kinase ◽  
Hypoxic Ischemic Encephalopathy ◽  
Case Group ◽  
Term Neonates ◽  
Mortality And Morbidity ◽  
Ischemic Encephalopathy

Background: Birth asphyxia in neonates significantly contributes to their mortality and morbidity, as it leads to hypoxic ischemic encephalopathy (HIE) and multi organ dysfunction. The present study was conducted with an objective to ascertain whether serum levels of creatinine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) can distinguish an asphyxiated from a non-asphyxiated term neonate and correlation of these enzymes cut-off levels with severity of HIE in asphyxiated term neonates.Methods: This prospective study was conducted at Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari from September 2012 to December 2013. The study included 50 cases (asphyxiated neonates) and 50 controls (non-asphyxiated neonates) after fulfilling the requirements of inclusion criteria. Their blood samples were collected at 8±2 hours and 72±2 hours of age for estimation of CK-MB and LDH respectively and sent for analysis. The values were compared between cases and controls by using descriptive statistics.Results: The mean CK-MB level at 8±2 hours and mean LDH level at 72±2 hours were significantly higher in cases compared to controls with p<0.001. Among the 50 neonates in case group, 19 (38%) had clinical evidence of HIE. Of them 3 (6%) had mild HIE, 12 (24%) had moderate HIE and 4 (8%) had severe HIE during the course in NICU. The correlation of Apgar scores of 0-3 and 4-6 at 1 minute and 5 minutes with the severity of HIE and the correlation of cut-off CK-MB level of 92.6 U/L and cut-off LDH level of 580 U/L with the severity of HIE were not significant (p>0.05).Conclusions: We conclude that estimating the levels CK-MB at 8 hours of life and LDH at 72 hours of life can help to distinguish an asphyxiated from a non-asphyxiated term neonate with reasonable degree of accuracy but the enzyme cut-off levels do not correlate with severity of HIE in asphyxiated term neonates. 

scholarly journals ACUTE KIDNEY INJURY IN ASPHYXIATED NEONATES AND ITS CORRELATION TO HYPOXIC ISCHEMIC ENCEPHALOPATHY STAGING

2016 ◽  
Vol 03 (03) ◽  
pp. 254-257
Author(s):  
Sumit Agrawal ◽  
Partha Kumar Chaudhuri ◽  
Anil Kumar Chaudhary ◽  
Deepak Kumar
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals Predictions of Hypoxic-Ischemic Encephalopathy by Umbilical Cord Blood Lactate in Newborns with Birth Asphyxia

2019 ◽  
Vol 7 (21) ◽  
pp. 3564-3567
Author(s):  
Ton Nu Van Anh ◽  
Tran Kiem Hao ◽  
Nguyen Thi Diem Chi ◽  
Nguyen Huu Son
Keyword(s):  
Cord Blood ◽  
Blood Lactate ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Hypoxic Ischemic Encephalopathy ◽  
Early Predictors ◽  
Ischemic Encephalopathy

AIM: The aim of the study was to investigate the role of umbilical cord blood lactate as early predictors of hypoxic ischemic encephalopathy in newborns with perinatal asphyxia and to evaluate their sensitivity and specificity for the early identification of hypoxic ischemic encephalopathy infants. METHODS: We performed а descriptive cross sectionаl study between Аpril 2014 аnd Аpril 2015 аt Hue Central Hospital, Vietnаm. 41 аsphyxiа newborns (Apgar score ≤ 7) were included in the study. Umbilicаl cord blood is sаmpled for lаctаte аnаlysis. RESULTS: Umbilicаl cord blood lаctаte levels were significаntly higher аmong infаnts born with HIE (meаn 8.72 ± 1.75, rаnge 5.12 – 11.96) compаred to thаt with asphyxic infаnts without HIE (meаn 6.86 ± 1.33, rаnge 4.74 – 10.30), p = 0.00. With the optimаl cutoff point for umbilicаl cord blood lаctаte level of 8.12 mmol/l to susspected of HIE (аreа under the curve 0.799) hаd а sensitivity 73.7% (95% CI: 48.8-90.9), specificity 86.4% (95% CI: 65.1-97.1). CONCLUSION: Umbilical cord blood lactate could be used as early predictors in diagnosis of hypoxic ischemic encephalopathy in newborns with asphyxia.

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