scholarly journals Serum adiponectin among different stages of type 2 diabetes mellitus patients

2021 ◽  
Vol 7 (4) ◽  
pp. 155-161
Author(s):  
Dr. Rashmi G S Basavaraj ◽  
◽  
Dr. Ravikumar Malladad ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Early Detection ◽  
Urinary Albumin ◽  
Serum Adiponectin ◽  
Different Types ◽  
Blood And Urine Samples

Background: Type 2 diabetes mellitus is a chronic metabolic disorder that leads to micro andmacrovascular complications. Nephropathy is the most common microvascular complication. Fordiagnosis of nephropathy in T2DM patients by using urinary albumin, this is not a sensitive andspecific biomarker because it is elevated in other conditions. we aimed to evaluate the serumadiponectin for early detection of nephropathy in patients with type 2 diabetes mellitus. Methods: Atotal of 60 subjects were included in the present study and further subdivided into 30 patients T2DMwith normoalbuminuria, 30 patients with microalbuminuria. All the patients were included afterobtaining institutional ethical permission and consent forms. Blood and urine samples were collectedfrom all the subjects and proceed with further analysis. Appropriate statistical analyses were usedfor different types of data analysis. Results: Increased levels of FBS, PPBS, HbA1C and serumadiponectin were observed in two groups of T2DM patients. Statistically elevated levels of serumUrea, Creatinine and Uric acid levels were observed in patients T2DM with microalbuminuria whencompared to T2DM with normoalbuminuria. The serum adiponectin was positively correlated withFBS, PPBS, HbA1C, Urea, Creatinine, Uric Acid and Urinary Albumin in patients with two groups ofT2DM. Conclusion: This study concluded that measuring the serum adiponectin levels may beuseful for the early detection of nephropathy in patients with T2DM.

scholarly journals Correlation of glycosylated hemoglobin with urinary albuminuria for early detection and progression of nephropathy in patients with type 2 diabetes millitus

2021 ◽  
Vol 8 (4) ◽  
pp. 433-436
Author(s):  
Ravikumar Malladad ◽  
Rashmi G S Basavaraj
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Early Detection ◽  
Continuous Monitoring ◽  
Glycosylated Hemoglobin ◽  
Urinary Albumin ◽  
Healthy Controls

diabetic nephropathy is a one of the most leading disorder in patients with type 2 diabetes mellitus. Urinary albuminuria used for detection of nephropathy in type 2 diabetes mellitus but its not an a sensitive and specific biomarker for DN. Recent studies found some of the sensitive and specific biomarker for early detection and progression of nephropathy in type 2 diabetes mellitus patients. A total 150 subjects included in the present study in that 100 patients diagnosed with type 2 diabetes mellitus and 50 healthy controls. All the subjects included after informed consent and blood, urine samples were collected from the all the subjects. FBS, PPBS, Urea, Creatinine, Uric acid, HbA1C and Urinary Albumin was analysed by using laboratory standard methods. statistically elevated levels of plasma FBS, PPBS, HbA1C in both the groups of type 2 diabetes mellitus when compared to healthy controls. Serum Urea, Creatinine and Uric Acid levels elevated in type 2 diabetes mellitus with microalbuminuria when compared to other two groups of study subjects. The Glycosylated hemoglobin positively correlated with urinary microalbuminuria in patients with two groups of type 2 diabetes mellitus. This study suggest that the poor glycemic control leads to increased further complications in patients with type 2 diabetes mellitus. Continuous monitoring of HbA1C and Urinary Albumin Levels were useful for progression and treatment of patients with type 2 diabetes mellitus.

scholarly journals THE STUDY ON ASSOCIATION BETWEEN URIC ACID AND ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 1-3
Author(s):  
Sk. Adnan Yusuf ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
General Medicine ◽  
Urinary Albumin ◽  
Chronic Hyperglycemia

Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins resulting from defects in insulin secretion, action or both. Aims & objectives: The aim of this study is to evaluate the association between serum uric acid & urinary Albumin to Creatinine Ratio (ACR) among patients with type 2 diabetes mellitus. Material and Methods: 83 patients aged between 40 to 80 years was selected from Medicine OPD and indoor wards, Department of General Medicine, KPC Medical College & Hospital, West Bengal from 1august 2019 to 1august 2020. Type 2 Diabetics Melitus (T2DM) patients, Age: between 40 to 80 years. Age, Body weight, Height, BMI, serum uric acid, urinary albumin to creatine ratio (ACR), Fasting Blood Glucose (FBG), HbA1C, lipid profile, serum creatinine. Conclusion: Present study found that positive correlation between serum uric acid with DBP, FBS, HB1AC, Serum Createnine, TG and LDL. There was negative correlation between serum uric acid with GFR and HDL, which were statistically significant.

scholarly journals Study of serum adiponectin levels for early detection of type 2 diabetes mellitus and its complications on kidney

2021 ◽  
Vol 8 (2) ◽  
pp. 171
Author(s):  
Harish K. V. ◽  
Hareesh R. ◽  
Akshatha Savith
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Serum Adiponectin ◽  
Healthy Controls ◽  
Newly Diagnosed

Background: Type 2 diabetes mellitus is a chronic metabolic disorder due to insulin resistance caused by destruction of beta cells of pancreas. Insulin resistance in newly diagnosed type 2 diabetes mellitus patients leads to hyperglycemia. Serum adiponectin is a more sensitive and specific biomarker for early detection of diabetic nephropathy than urinary microalbuminuria.Methods: This is a case-control study conducted in Akash Institute of Medical Sciences, A total 180 subjects (120 cases and 60 controls). All the subjects included after informed consent, blood samples and urine samples are collected from the all the subjects. The serum Adiponectin and was estimated by using enzyme-linked immunoassay (ELISA) and fasting blood sugar (FBS), post prandial blood sugar (PPBS) and renal function test (RFT) was also estimated by laboratory standard methods.Results: This study was evaluated the FBS, PPBS, RFT and serum adiponectin levels in patients with type 2 diabetes mellitus patients and compare them with healthy controls. The serum adiponectin levels more significantly elevated in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls. The study also found that significantly elevated levels of FBS, PPBS and RFT in type 2 diabetes mellitus patients and compared with the healthy controls, The statistically significant levels of serum adiponectin in patients with type 2 diabetes mellitus and when compared with the controls (p= 0.0001).Conclusions: The study suggesting that the s estimation of serum adiponectin levels in newly diagnosed type 2 diabetes mellitus patients useful for early detection of diabetic nephropathy. Because elevated levels of serum adiponectin in patients with newly diagnosed type 2 diabetes mellitus, this levels are positively correlated with the FBS and PPBS. 

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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