scholarly journals Correlation of glycosylated hemoglobin with urinary albuminuria for early detection and progression of nephropathy in patients with type 2 diabetes millitus

2021 ◽  
Vol 8 (4) ◽  
pp. 433-436
Author(s):  
Ravikumar Malladad ◽  
Rashmi G S Basavaraj
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Early Detection ◽  
Continuous Monitoring ◽  
Glycosylated Hemoglobin ◽  
Urinary Albumin ◽  
Healthy Controls

diabetic nephropathy is a one of the most leading disorder in patients with type 2 diabetes mellitus. Urinary albuminuria used for detection of nephropathy in type 2 diabetes mellitus but its not an a sensitive and specific biomarker for DN. Recent studies found some of the sensitive and specific biomarker for early detection and progression of nephropathy in type 2 diabetes mellitus patients. A total 150 subjects included in the present study in that 100 patients diagnosed with type 2 diabetes mellitus and 50 healthy controls. All the subjects included after informed consent and blood, urine samples were collected from the all the subjects. FBS, PPBS, Urea, Creatinine, Uric acid, HbA1C and Urinary Albumin was analysed by using laboratory standard methods. statistically elevated levels of plasma FBS, PPBS, HbA1C in both the groups of type 2 diabetes mellitus when compared to healthy controls. Serum Urea, Creatinine and Uric Acid levels elevated in type 2 diabetes mellitus with microalbuminuria when compared to other two groups of study subjects. The Glycosylated hemoglobin positively correlated with urinary microalbuminuria in patients with two groups of type 2 diabetes mellitus. This study suggest that the poor glycemic control leads to increased further complications in patients with type 2 diabetes mellitus. Continuous monitoring of HbA1C and Urinary Albumin Levels were useful for progression and treatment of patients with type 2 diabetes mellitus.

scholarly journals Serum adiponectin among different stages of type 2 diabetes mellitus patients

2021 ◽  
Vol 7 (4) ◽  
pp. 155-161
Author(s):  
Dr. Rashmi G S Basavaraj ◽  
◽  
Dr. Ravikumar Malladad ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Early Detection ◽  
Urinary Albumin ◽  
Serum Adiponectin ◽  
Different Types ◽  
Blood And Urine Samples

Background: Type 2 diabetes mellitus is a chronic metabolic disorder that leads to micro andmacrovascular complications. Nephropathy is the most common microvascular complication. Fordiagnosis of nephropathy in T2DM patients by using urinary albumin, this is not a sensitive andspecific biomarker because it is elevated in other conditions. we aimed to evaluate the serumadiponectin for early detection of nephropathy in patients with type 2 diabetes mellitus. Methods: Atotal of 60 subjects were included in the present study and further subdivided into 30 patients T2DMwith normoalbuminuria, 30 patients with microalbuminuria. All the patients were included afterobtaining institutional ethical permission and consent forms. Blood and urine samples were collectedfrom all the subjects and proceed with further analysis. Appropriate statistical analyses were usedfor different types of data analysis. Results: Increased levels of FBS, PPBS, HbA1C and serumadiponectin were observed in two groups of T2DM patients. Statistically elevated levels of serumUrea, Creatinine and Uric acid levels were observed in patients T2DM with microalbuminuria whencompared to T2DM with normoalbuminuria. The serum adiponectin was positively correlated withFBS, PPBS, HbA1C, Urea, Creatinine, Uric Acid and Urinary Albumin in patients with two groups ofT2DM. Conclusion: This study concluded that measuring the serum adiponectin levels may beuseful for the early detection of nephropathy in patients with T2DM.

scholarly journals THE ROLE OF METABOLIC DISORDERS IN THE FORMATION OF UROLITHIASIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
Vol 77 (3) ◽  
pp. 52-57
Author(s):  
S. M. Kolupayev ◽  
N. M. Andonieva ◽  
O. M. Kirienko ◽  
V. V. Khanzhyn ◽  
D. O. Iemets
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Mineral Composition ◽  
Stone Formation ◽  
Glycosylated Hemoglobin ◽  
Duration Of Diabetes ◽  
Extracorporeal Shock Wave

The article presents the study of the influence of type 2 diabetes mellitus on the features of the urolithiasis development and factors affecting stone formation. As part of the study, 28 patients with type 2 diabetes mellitus were treated at the «Regional Medical Clinical Center of Urology and Nephrology named after V. I. Shapoval», where a comprehensive examination was carried out to determine the level of glycosylated hemoglobin, glomerular filtration rate, serum concentration of triglycerides, urea, creatinine and uric acid. All patients underwent ultrasound examination of the urinary system organs. In case of detecting stones in the kidneys or urinary tract, multispiral computed tomography with contrast was performed, which evaluated the size, localization and X-ray density of the stones. Depending on the above parameters, patients underwent extracorporeal shock wave lithotripsy, contact laser ureterolithotripsy or percutaneous  nephrolithotripsy, followed by assessment of the mineral composition of the obtained stone fragments by infrared spectroscopy. The study revealed a positive correlation between the level of uric acid in the blood and the duration of diabetes mellitus both in men (r = 0.64, р < 0.05) and in women (r = 0.58, р < 0.05), while the concentration of uricacid in the blood did not depend on the age and gender of the patients. There was a direct relationship betweenhyperuricemia and the concentration of glycosylated hemoglobin. The level of uricemia increased simultaneously with the level of creatinine in the blood. Urolithiasis was diagnosed in 67.8% of the examined patients. There was a significant increase in the number of cases of urolithiasis with an increase in the duration of diabetes mellitus (r = 0.64, p < 0.05). In 68.4% of patients, stones had a monophasic composition, which was represented by uric acid or uric acid dihydrate.In 31.5% of cases, stones had a mixed mineral composition, with uric acid being the dominant component, occupyingmore than 50% of the sample volume.

scholarly journals THE STUDY ON ASSOCIATION BETWEEN URIC ACID AND ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 1-3
Author(s):  
Sk. Adnan Yusuf ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
General Medicine ◽  
Urinary Albumin ◽  
Chronic Hyperglycemia

Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins resulting from defects in insulin secretion, action or both. Aims & objectives: The aim of this study is to evaluate the association between serum uric acid & urinary Albumin to Creatinine Ratio (ACR) among patients with type 2 diabetes mellitus. Material and Methods: 83 patients aged between 40 to 80 years was selected from Medicine OPD and indoor wards, Department of General Medicine, KPC Medical College & Hospital, West Bengal from 1august 2019 to 1august 2020. Type 2 Diabetics Melitus (T2DM) patients, Age: between 40 to 80 years. Age, Body weight, Height, BMI, serum uric acid, urinary albumin to creatine ratio (ACR), Fasting Blood Glucose (FBG), HbA1C, lipid profile, serum creatinine. Conclusion: Present study found that positive correlation between serum uric acid with DBP, FBS, HB1AC, Serum Createnine, TG and LDL. There was negative correlation between serum uric acid with GFR and HDL, which were statistically significant.

scholarly journals Study of serum adiponectin levels for early detection of type 2 diabetes mellitus and its complications on kidney

2021 ◽  
Vol 8 (2) ◽  
pp. 171
Author(s):  
Harish K. V. ◽  
Hareesh R. ◽  
Akshatha Savith
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Serum Adiponectin ◽  
Healthy Controls ◽  
Newly Diagnosed

Background: Type 2 diabetes mellitus is a chronic metabolic disorder due to insulin resistance caused by destruction of beta cells of pancreas. Insulin resistance in newly diagnosed type 2 diabetes mellitus patients leads to hyperglycemia. Serum adiponectin is a more sensitive and specific biomarker for early detection of diabetic nephropathy than urinary microalbuminuria.Methods: This is a case-control study conducted in Akash Institute of Medical Sciences, A total 180 subjects (120 cases and 60 controls). All the subjects included after informed consent, blood samples and urine samples are collected from the all the subjects. The serum Adiponectin and was estimated by using enzyme-linked immunoassay (ELISA) and fasting blood sugar (FBS), post prandial blood sugar (PPBS) and renal function test (RFT) was also estimated by laboratory standard methods.Results: This study was evaluated the FBS, PPBS, RFT and serum adiponectin levels in patients with type 2 diabetes mellitus patients and compare them with healthy controls. The serum adiponectin levels more significantly elevated in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls. The study also found that significantly elevated levels of FBS, PPBS and RFT in type 2 diabetes mellitus patients and compared with the healthy controls, The statistically significant levels of serum adiponectin in patients with type 2 diabetes mellitus and when compared with the controls (p= 0.0001).Conclusions: The study suggesting that the s estimation of serum adiponectin levels in newly diagnosed type 2 diabetes mellitus patients useful for early detection of diabetic nephropathy. Because elevated levels of serum adiponectin in patients with newly diagnosed type 2 diabetes mellitus, this levels are positively correlated with the FBS and PPBS. 

scholarly journals Correlation of Uric Acid with Oxidative Stress and Endothelial Dysfunction in Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Siva Prasad Palem
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Endothelial Dysfunction ◽  
P Value ◽  
Healthy Controls ◽  
Antioxidant Power

Objective: To evaluate the correlation of uric acid with oxidative stress and endothelial dysfunction in type 2 diabetic subjects.Material and Methods: The study included 120 subjects, among when 60 were type 2 diabetes subjects and the remaining 60 were age and gender matched healthy controls. The biochemical parameters, blood glucose, lipid profile, uric acid and homocysteine, were measured by standard kits in an autoanalyzer. Oxidative stress was evaluated by measuring malondialdehyde (MDA) and total antioxidant power by manual methods such as thio-barbituric acid reactive substances and ferric reducing ability of plasma (FRAP). Endothelial dysfunction was assessed by measuring nitric oxide (NO) by the kinetic cadmium method.Results: A significant elevation of triglycerides, low density lipoprotein (LDL), and MDA were observed in the type 2 diabetes mellitus patients while FRAP and NO were significantly reduced compared to the healthy controls. In addition, the uric acid levels had a highly significant correlation with FRAP (r=0.212, p-value=0.020), and moderately significant correlation with triglycerides (r=0.173, p-value=0.057) and homocysteine (r=0.178, p-value=0.051). Uric acid was negatively correlated with MDA and positively correlated with NO, but not statistically significant.Conclusion: Our findings suggest that uric acid may have antioxidant properties since it had a significant positive correlation with FRAP.

CORRELATION OF HbA1C WITH MICROALBUMINURIA IN TYPE-2 DIABETES MELLITUS PATIENTS

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Anil Kumar ◽  
Dr. Neha ◽  
Dr. Madhuri Meena ◽  
Dr. Y. K. Sanadhya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Albumin Level ◽  
Urinary Albumin ◽  
P Value ◽  
Common Disease ◽  
Care Hospital

Background: Diabetes is a very common disease now a days . It has adverse effect on many human organs as its duration increases. Many studies exist to show its bad effects on body organs in different parts of world. We have studied is there any relation between microalbuminuria with HbA1c levels. Methods: we have done a cross sectional study from January 2016 to March 2017 in a tertiary health care hospital located in Jhalawar, Rajasthan. Our study includes all the known case of type 2 diabetes mellitus patients of age group of 45 years and above. Results: Total 69 patients had Urinary albumin level less than 30 mg/dl out of which Hb1Ac was less than 6.5% present in 20.2% of patients and 79.7% of patients had more than 6.5%. Total 31 patients had Urinary albumin level more than 30 mg/dl out of which only 3% had Hb1Ac value less than 6.5 % whereas 96% had Hb1Ac value more than 6.5%. This association was found to be clinically significant (Pearson Chi-Square- 4.888, df is 1 and p value is 0.027, Fishers Exact test is 0.033) Conclusion: Patients having microalbuminuria were associated with high level of glycosylated haemoglobin. Keywords: Diabetes Mellitus, Microalbuminuria, Glycosylated Hemoglobin.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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