Comparative analysis of long-term results of high-tech external beam therapy and combined radiotherapy in patients with prostate cancer and high risk of progression

Prostate cancer (PCa) of high risk is one of the crucial problems in urological oncology. Radiation therapy (RT), along with radical prostatectomy, is an important component of the complex treatment of patients with high‑risk PCa. To improve the long‑term oncological results of RT dose escalation is advocated. Currently, dose escalation can be reached via external beam irradiation and interstitial RT techniques. The study included 109 patients with high‑risk PCa who underwent either external beam RT up to 76 Gy, or combined RT (external beam + interstitial RT) using 125I sources with long‑term androgen deprivation therapy. Comparative analysis of long‑term results of patients with high‑risk PCa treatment showed an improvement in 5‑year disease‑free survival rates after combined RT compared with external beam RT. Acute rectal toxicity was decreased in combined RT group compared to patients after external beam RT: 13.2 % and 46.4 %, respectively (p < 0.01).

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LONG-TERM RESULTS OF EXTERNAL BEAM RADIATION THERAPY IN MEN WITH NEWLY DIAGNOSED PROSTATE CANCER WITH DIFFERENT RISK OF PROGRESSION

Herald Urology ◽

10.21886/2308-6424-2015-0-3-42-53 ◽

2015 ◽

pp. 42-53

Author(s):

P. D. Demeshko ◽

S. A. Krasny

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

External Beam Radiation Therapy ◽

External Beam Radiation ◽

Long Term Results ◽

External Beam ◽

Newly Diagnosed ◽

Beam Radiation ◽

Risk Of Progression

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LOW-DOSE-RATE OR HIGH-DOSE-RATE BRACHYTHERAPY IN COMBINATION WITH EXTERNAL BEAM RADIOTHERAPY FOR INTERMEDIATE AND HIGH-RISK PROSTATE CANCER

Problems in oncology ◽

10.37469/0507-3758-2018-64-1-79-83 ◽

2018 ◽

Vol 64 (1) ◽

pp. 79-83

Author(s):

Vladimir Solodkiy ◽

Andrey Pavlov ◽

Aleksey Tsybulskiy ◽

Anton Ivashin

Keyword(s):

Prostate Cancer ◽

High Risk ◽

Dose Rate ◽

Low Dose ◽

External Beam Radiotherapy ◽

Combined Treatment ◽

High Dose ◽

External Beam ◽

Low Dose Rate ◽

Risk Of Progression

Introduction. One of the main problems of modem on-courology is treatment for prostate cancer of intermediate and high risk of progression. Modern radiotherapy in this category of patients has an advantage over surgical methods of treatment. One way to improve the effectiveness of radiotherapy is to escalate the dose in the prostate gland. For this purpose a combination of brachytherapy and remote radiotherapy is used. This combination allows increasing the dose of radiation, thereby providing better local control, reducing complications from neighboring organs. Purpose of the study. To conduct a comparative analysis of efficacy and safety of radical treatment of patients with prostate cancer at medium and high risk of progression using a combination of high and low dose rate brachytherapy with external beam radiotherapy. Materials and methods. 107 patients with prostate cancer of the group of medium and high risk of progression combined treatment (brachytherapy with external beam radiotherapy) was conducted. 53 patients underwent combined treatment (HDR-brachytherapy and external beam radiotherapy). 54 patients underwent combined treatment (LDR-brachytherapy and external beam radiotherapy). The observation period was 5 years. Conclusion. In a comparative analysis in groups of combined radiotherapy with the use of high-dose and low-dose-rate brachytherapy, the same effectiveness of immediate and long-term results of treatment was demonstrated. A significant reduction in early and late toxic reactions in patients with high-power brachytherapy has been demonstrated.

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