Central renal cell carcinoma: a diagnostic dilemma

Centrally Located renal tumor poses a diagnostic challenge to differentiate between renal cell carcinoma and transitional cell carcinoma. Imaging alone is not sufficient to make the diagnosis, some invasive diagnostic investigations are required to ascertain the diagnosis. We present a 60 years old gentleman, who presented dyspepsia and further investigation by contrasted CT kidney revealed a centrally located right renal tumor. Before making a management decision, we performed the right renal biopsy of the tumor which turns out to be a renal cell carcinoma. Henceforth, we performed a robotic-assisted laparoscopic right nephrectomy. A renal biopsy, in this case, assisted to decide only radical nephrectomy instead of radical nephroureterectomy which has higher associated morbidity. Thus, it is important to make confirm by tissue biopsy before deciding on surgery in case of the central renal tumor as this prevents subjecting a patient to under-or overtreatment.

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Tubulocystic renal cell carcinoma: Report of a rare case

Canadian Urological Association Journal ◽

10.5489/cuaj.2935 ◽

2015 ◽

Vol 9 (9-10) ◽

pp. 654 ◽

Cited By ~ 2

Author(s):

Aanchal Kakkar ◽

Mehar C. Sharma ◽

Manpreet Uppal ◽

Sunil Chumber

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Histopathological Examination ◽

Cystic Neoplasm ◽

Diagnostic Challenge ◽

Elderly Male ◽

Diagnostic Dilemma ◽

Cystic Neoplasms ◽

Atypical Cells

Cystic neoplasms of the kidney are rare, and present a unique diagnostic challenge. We report the case of an elderly male who presented with a large cystic neoplasm, which was a diagnostic dilemma clinically and radiologically. Histopathological examination showed a tumour composed of variably sized tubules lined by atypical cells having large round nuclei with prominent nucleoli. Hobnailing was seen at places. Tumour cells were immunopositive for pancytokeratin, vimentin, CD10, CK19 and AMACR, confirming a diagnosis of tubulocystic renal cell carcinoma (TC-RCC).

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A hemodialysis patient with simultaneous occurrence of renal cell carcinoma and transitional cell carcinoma in the right kidney

Nihon Toseki Igakkai Zasshi ◽

10.4009/jsdt.38.1345 ◽

2005 ◽

Vol 38 (7) ◽

pp. 1345-1349

Author(s):

Akira Ishikawa ◽

Yasushi Kondo ◽

Haruki Kume ◽

Hiroshi Yokoyama ◽

Norio Hanafusa ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Hemodialysis Patient ◽

Transitional Cell ◽

Simultaneous Occurrence ◽

The Right

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Two Different Upper Tract Urological Malignancies on Either Side

Case Reports in Urology ◽

10.1155/2021/9981381 ◽

2021 ◽

Vol 2021 ◽

pp. 1-4

Author(s):

W. S. L. De Silva ◽

S. R. De Almeida ◽

G. D. B. J. Karunarathne ◽

A. A. S. Samarathunga ◽

K. M. C. S. Gannoruwa ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Renal Mass ◽

Transitional Cell ◽

Upper Tract Urothelial Carcinoma ◽

Malignant Neoplasms ◽

Upper Tract ◽

The Right

Introduction. The genitourinary system is a recognized site for multiple primary malignant neoplasms even without syndromic anomalies. However, to the best of our knowledge, a case of upper tract urothelial carcinoma (UTUC) with contralateral renal cell carcinoma (RCC) is not reported in surgical literature so far. Case Presentation. A 52-year-old Sri Lankan male patient was found to have a right lower ureteric tumour and a left renal mass together upon investigating for painless visible hematuria. The right ureteric tumour measured 32 × 22 mm resulting in moderate hydronephrosis and cortical thinning of the right kidney, and the left renal mass measured 43 × 38 mm involving the lower pole. The biopsy of the right ureteric lesion revealed a high-grade transitional cell carcinoma with focal nested pattern and that of the left renal mass revealed a clear cell carcinoma. Right nephroureterectomy followed by a left partial nephrectomy was performed in six weeks’ interval. The histology of both the resected specimens confirmed the biopsy findings. Discussion. A high-risk upper tract urothelial carcinoma such as the right ureteric tumour of this patient required a nephroureterectomy which makes the management of the contralateral renal cell carcinoma more complex. An adequate functional renal remnant was ensured after offering oncologically sound surgical treatment for both the malignancies of this patient. Conclusion. A UTUC when associated with a contralateral RCC poses challenges in patient management. The preservation of renal excretory function has to be considered as an important determinant in addition to oncologically sound surgical resection when managing complex cases of genitourinary malignancies involving both sides of the upper urinary tract.

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CT Differentiation of Renal Tumor Invading Parenchyma and Pelvis: Renal Cell Carcinoma vs Transitional Cell Carcinoma

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1994.31.6.1143 ◽

1994 ◽

Vol 31 (6) ◽

pp. 1143

Author(s):

Cheol Min Park ◽

IN Ho Cha ◽

Kyoo Byung Chung ◽

Chang Hee Lee ◽

Seong Beum Cho

Keyword(s):

Renal Cell Carcinoma ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Renal Tumor ◽

Transitional Cell

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Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology ( SIOP ) 93‐01, 2001 and UK‐IMPORT database: A report of the SIOP‐Renal Tumor Study Group

International Journal of Cancer ◽

10.1002/ijc.33476 ◽

2021 ◽

Author(s):

Justine N. van der Beek ◽

Janna A. Hol ◽

Aurore Coulomb‐l'Hermine ◽

Norbert Graf ◽

Harm van Tinteren ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

International Society ◽

Pediatric Oncology ◽

Renal Cell ◽

Renal Tumor ◽

Study Group ◽

Tumor Study ◽

Pediatric Renal Cell Carcinoma ◽

Tumor Study Group

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Clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma: two case reports and literature review

Aktuelle Urologie ◽

10.1055/a-1139-0697 ◽

2020 ◽

Author(s):

Dalin Feng ◽

Mingshuai Wang ◽

Xiaodong Zhang ◽

Jianwen Wang

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Female Patient ◽

Male Patient ◽

Renal Cell ◽

Clinical Characteristics ◽

Genetic Test ◽

Enhanced Ct ◽

The Right ◽

Hereditary Leiomyomatosis

Abstract Background The objective of this study is to discuss clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma on the basis of 2 cases and to review recent literature, in order to present medical advances. Methods A 29-year old male patient came to our hospital because of a huge tumour on the right kidney. Enhanced CT showed that the tumour was about 15.5*10.5 cm, and was considered to be malignant. Another case was a 38-year old female patient. She complained was found to have a right kidney tumour in a routine physical examination. Enhanced CT showed an early-stage tumour of about 4.3*3.7 cm on the lower pole of the right kidney. The male patient underwent open radical nephrectomy and the female patient underwent laparoscopic radical nephrectomy and extensive retroperitoneal lymph node dissection. The two patients underwent genetic testing and were diagnosed as having hereditary leiomyomatosis with renal cell carcinoma. Results The postoperative pathology in both patients revealed type 2 papillary renal cell carcinoma but with different prognosis. The male patient suffered multiple metastasis 10 months post-operation. The metastatic tumour of the abdominal wall was resected to confirm recurrence and hereditary leiomyomatosis renal cell carcinoma was diagnosed by the genetic test. While the female patient had a specific family history and uterine leiomyomas, the genetic test helped us to identify hereditary leiomyomatosis renal cell carcinoma pre-operation. Because of the early diagnosis and timely treatment, the female patient was considered to have a good prognosis. Conclusion Hereditary leiomyomatosis renal cell carcinoma is a rare hereditary disease resulting from FH gene mutation. There are currently no effective treatments.Our cases demonstrate that hereditary leiomyomatosis renal cell carcinoma is a very aggressive disease. Early screening and surveillance are recommended for patients with a family history or who are at risk of hereditary leiomyomatosis renal cell carcinoma. Surgical and palliative therapy still play an important role in clinical treatment.

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Metastatic renal cell carcinoma extending to the left atrium through the inferior pulmonary vein

Interactive Cardiovascular and Thoracic Surgery ◽

10.1093/icvts/ivab018 ◽

2021 ◽

Author(s):

Alan G Dawson ◽

Cathy J Richards ◽

Leonidas Hadjinikolaou ◽

Apostolos Nakas

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Left Atrium ◽

Pulmonary Vein ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Pulmonary Veins ◽

Lower Lobe ◽

Inferior Pulmonary Vein ◽

The Right

Abstract Metastatic renal cell carcinoma with involvement through the pulmonary veins to the left atrium is very rare. We report the case of a 70-year-old male with metastatic renal cell carcinoma to the right lower lobe of the lung abutting the inferior pulmonary vein with extension to the left atrium without pre-operative evidence. Surgical resection was achieved through a posterolateral thoracotomy. Lung masses that abut the pulmonary veins should prompt further investigation with a pre-operative transoesophageal echocardiogram to minimize unexpected intraoperative findings.

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