scholarly journals Batch and Flow injection Spectrophotometric Methods For Determination of Folic acid in Pharmaceutical Preparations using Cerium(IV) ammonium sulphate(CAS) as an oxidant.

2018 ◽  
Vol 20 (2) ◽  
pp. 21-34
Author(s):  
Shirwan Omer Baban Baban ◽  
◽  
Kurdistan F. Azeez Azeez ◽  
Keyword(s):  
Folic Acid ◽  
Ammonium Sulphate ◽  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Spectrophotometric Methods

scholarly journals Optimization of Two Flow-Injection Spectrophotometric Methods for the Determination of Indapamide in Pharmaceutical Dosage Forms

2005 ◽  
Vol 88 (4) ◽  
pp. 1148-1154 ◽  
Author(s):  
Juan C Rodríguez ◽  
Julia Barciela ◽  
Sagrario García ◽  
Carlos Herrero ◽  
Rosa M Peña
Keyword(s):  
Flow Injection ◽  
Screening Method ◽  
Pharmaceutical Preparations ◽  
Dosage Forms ◽  
Response Surfaces ◽  
Subsequent Formation ◽  
Pharmaceutical Dosage Forms ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision

Abstract Multivariate experimental design has been used to optimize 2 flow-injection spectrophotometric methods for the determination of indapamide in pharmaceutical dosage forms, both pure and commercial tablets. The methods are based on the oxidation of this drug with iron (III) in acidic medium and the subsequent formation of an intensive orange-red complex between the liberated iron (II) and 2,2′-bipyridyl or 1,10-phenanthroline reagents. Plackett-Burman designs were applied as a screening method to evaluate the most significant factors with few experiments. Central composite 23+ star designs were performed to evaluate the response surfaces. The methods have been fully validated and were applied successfully to the determination of indapamide in pure and pharmaceutical forms with good accuracy and precision. Therefore, the 2 proposed procedures are simple, inexpensive, and rapid flow methods for the routine determination of indapamide in pharmaceutical preparations.

scholarly journals Batch and Flow-Injection Spectrophotometric Determination of Procaine HCl in Pharmaceutical Preparations Via Using Diazotization and Coupling Reaction

2012 ◽  
Vol 9 (3) ◽  
pp. 521-531
Author(s):  
Baghdad Science Journal
Keyword(s):  
Flow Injection ◽  
Diazonium Salt ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Standard Addition ◽  
Water Soluble ◽  
Spectrophotometric Methods ◽  
Colored Product ◽  
Average Sample

Simple and sensitive batch and Flow-injection spectrophotometric methods for the determination of Procaine HCl in pure form and in injections were proposed. These methods were based on a diazotization reaction of procaine HCl with sodium nitrite and hydrochloric acid to form diazonium salt, which is coupled with chromatropic acid in alkaline medium to form an intense pink water-soluble dye that is stable and has a maximum absorption at 508 nm. A graphs of absorbance versus concentration show that Beer’s law is obeyed over the concentration range of 1-40 and 5-400 µg.ml-1 of Procaine HCl, with detection limits of 0.874 and 3.75 µg.ml-1 of Procaine HCl for batch and FIA methods respectively. The FIA average sample throughput was 70 h-1. All different chemical and physical experimental parameters that affecting on the development and stability of the colored product were carefully studied and the proposed methods were applied satisfactorily for the determination of Procaine HCl in an injections samples using the standard addition method.

Colorimetric Determination of Amoxicillin in Pure and some Pharmaceutical Formulations Via Reaction with Potassium Permanganate as Oxidant Reagent

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Abbas Shebeeb Al-kadumi ◽  
Sahar Rihan Fadhel ◽  
Mohammed Abdullah Ahmed ◽  
Luma Amer Musa
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Atomic Emission ◽  
Basic Medium ◽  
Photometric Method ◽  
Colorimetric Determination ◽  
Spectrophotometric Methods ◽  
Label Claim

We proposed two simple, rapid, and convenient spectrophotometric methods are described for the determination of Amoxicillin in bulk and its pharmaceutical preparations. They are based on the measurement of the flame atomic emission of potassium ion (in first method) and colorimetric determination of the green colored solution for manganite ion at 610 nm formed after reaction of Amoxicillin with potassium permanganate as oxidant agent (in the second method) in basic medium. The working conditions of the methods were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 5-45 μg/ml. The detection limits and relative standared deviations were (2.573, 2.814 μg/ml) (2.137, 2.498) for the flame emission photometric method and (1.844, 2.016 μg/ml) (1.645,1.932) for colorimetric methods for capsules and suspensions respectively. The methods were successfully applied to the determination of Amoxicillin in capsules and suspensions, and the obtained results were in good agreement with the label claim. No interference was observed from the commonly encountered additives and expectancies.

Flow-Injection Fluorimetric Determination of Thiamine in Pharmaceutical Preparations

2000 ◽  
Vol 134 (1-2) ◽  
pp. 83-87 ◽  
Author(s):  
Pilar Vi�as ◽  
Carmen L�pez-Erroz ◽  
Francisco Jose� Cerd�n ◽  
Natalia Campillo ◽  
Manuel Hern�ndez-C�rdoba
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Fluorimetric Determination

scholarly journals Construction and evaluation of an automated flow injection-stopped flow analyser for multipoint reaction rate spectrophotometric methods. Determination of ammonia nitrogen, creatinine and phosphate

1991 ◽  
Vol 13 (5) ◽  
pp. 199-207 ◽  
Author(s):  
Constantinos A. Georgiou ◽  
Michael A. Koupparis
Keyword(s):  
Flow Injection ◽  
Reaction Rate ◽  
Assembly Language ◽  
Ammonia Nitrogen ◽  
Stopped Flow ◽  
Data Sampling ◽  
Ramp Generator ◽  
Spectrophotometric Methods ◽  
Blue Reaction

The construction and evaluation of a fully automated Flow Injection-Stopped Flow (FI-SF) spectrophotometric analyser is described. A microcomputer (Rockwell AIM 65) is used to control the analyser (sample injection, stop and start of the pump) through a suitable interface. Data acquisition is achieved using a 12 bit ADC card and a suitable subroutine in 6502 assembly language, allowing data sampling at a frequency of 7.5 kHz. The measurement interface and software were evaluated using a voltage ramp generator. A precision of 0.02-1.1% RSD (N =10) was obtained for voltage ramps in the range of 1-37 mVs-1. The FI-SF analyser was evaluated in routine analysis by developing FI-SF kinetic spectrophotometric methods for the determination of ammonia nitrogen (20-250 ppm, 0.4-2.5% RSD) based on the Berthelot reaction, creatinine (20-220 ppm, 0.9-3.6% RSD) based on the Jaffé reaction, and phosphate (5-30 ppm, 1.0-3.3% RSD) based on the phosphomolybdenum blue reaction. The reaction rate is measured by linear fitting of multiple absorbance readings vs time. Algorithms for automated estimation of the residence time, the linear range of the reaction curve, and data treatment are presented.

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