scholarly journals Clinical and immunological features of inflammation in lyme borreliosis

2016 ◽  
Vol 21 (2) ◽  
pp. 86-92
Author(s):  
D. Yu Moshkova ◽  
Marina G. Avdeeva
Keyword(s):  
Nervous System ◽  
Infectious Diseases ◽  
Cardiovascular System ◽  
Peripheral Nervous System ◽  
Lyme Borreliosis ◽  
Elevated Level ◽  
Normal Values ◽  
Causal Treatment ◽  
Anti Inflammatory ◽  
Chronic Course

The cytokine status was studied in 46patients hospitalized in Specialized Clinical Infectious Diseases Hospital in 2013-2014. Acute course of the infection of Ixodes tick borreliosis (ITB) was observed in the 41 (89%) case, subacute and chronic - in 5 (11%), in the dynamics of the disease there was studied the level of proinflammatory (IFN-y, IL-1β, IL-2) and anti-inflammatory ( IL-4, IL-10) cytokines. The average age of diseased patients in the acute course of the erythemalform of ITB amounted to 41,1 ± 1,83 years, men accouted for 37%, women - 63%. In 31.1% of the patients there were observed symptoms of the involvement of the peripheral nervous system PNC, in 51.1% - changes in the cardiovascular system. For the acute course of the erythemal form of ITB there is typical the significant increase ofIL-1β, IFN-y and IL-4 level, while in maintaining of normal levels of IL-2 and IL-10 low values in the majority of patients. In subacute and chronic course of Ixodes borreliosis there is persisted the elevated level of IL-1β, IFN-y, normal values of IL2 and low values of IL-10, while the level of IL-4 is also lowered. The increase of the IL-2 level in the acute course of the erythemal form of Ixodes borreliosis is associated with fever and involvement of the cardiovascular system. In the process of causal treatment with ceftriaxone (examination on the 5th and 12th day of the treatment) there was a significant decrease in the level of IL-2 (p

scholarly journals Predicting the risk of neurological complications in the erythemal form of ixodes Lyme disease

2016 ◽  
Vol 21 (6) ◽  
pp. 341-346
Author(s):  
D. Yu Moshkova ◽  
Marina G. Avdeeva
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Peripheral Nervous System ◽  
Lyme Borreliosis ◽  
Inflammatory Cytokine ◽  
Neurological Complications ◽  
Average Level ◽  
Pathogenetic Therapy ◽  
Chronic Course

The aim. The prediction of risk degrees of neurological complications in adult patients with erythemal form of borreliosis for the timely appointment of causal and pathogenetic therapy. Materials and methods. We observed 46 patients hospitalized in infectious hospital in Krasnodar in 2013-2014, with a diagnosis of Ixodes tick-borne Lyme disease, erythemal form, acute course was observed in 41 (89.1%) person, subacute - in 2 (4.4%), chronic - 3 (6.5%). In the course of the disease there was studied the level of pro-inflammatory cytokine IFN-y. Results. The average age of patients was 41.1 ± 1.83 years, among them women (63%) dominated. In 31% of patients there were observed symptoms of the damage of the nervous system. From the first week of the disease there was noted a significant increase in the level of IFN-y, which persisted both in the subacute and chronic course of the disease. The average level of IFN-y in patients with signs of the damage of the central and peripheral nervous system accounted for 64.8±14.19 pg/ml being ignificantly higher (P 20.0 pg/ml symptoms of the damage of the nervous system were recorded in 50% of cases. The degrees of neurological complications risk in patients with tick-borne Lyme disease are determined: the IFN-y level of 20.0-34.99 pg/ml predicted the risk of 1 degree (12.5%), level of 35,0-79,99 pg/ml - the risk of 2 degree (45%), the level higher than 80.0pg/ml - the risk of 3 degree (100%). Conclusion. The use of the determination of the IFN-y level can increase the accuracy and provide the timeliness of diagnosis of neurological complications in Lyme borreliosis cases, that is important for the prognosis and treatment of the disease.

The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction FromPhyllanthus niruriPlant Is Mediated via the Peripheral Nervous System

2010 ◽  
Vol 7 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Ifeoma Chinwude Obidike ◽  
Oluwakanyinsola Adeola Salawu ◽  
Mary Ndukuba ◽  
Charles Ogbonnaya Okoli ◽  
Uche Alex Osunkwo
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Chloroform Fraction ◽  
Anti Inflammatory

scholarly journals About lesions of the peripheral nervous system after influenza in the winter of 1931-1932. in Kazan

2021 ◽  
Vol 32 (8-9) ◽  
pp. 697-715
Author(s):  
I. I. Rusetsky
Keyword(s):  
Nervous System ◽  
Infectious Diseases ◽  
Peripheral Nervous System ◽  
Medical Practice ◽  
Working Hours ◽  
Epidemic Encephalitis ◽  
Rational Therapy ◽  
Large Groups

Since 1916-1917, the period of the last pandemic of epidemic encephalitis, infectious diseases of the nervous system have become common and fairly frequent in medical practice. Covering in some places large groups of the population and taking away a large number of working hours from socialist construction, these diseases should be the object of serious study by practically working doctors for their rational therapy and prevention.

Maceste and its importance in the treatment of diseases of the nervous system

1927 ◽  
Vol 23 (4) ◽  
pp. 464-464
Author(s):  
V. I. Znamensky
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiovascular System ◽  
Peripheral Nervous System ◽  
Tabes Dorsalis ◽  
The Central Nervous System ◽  
The Brain

According to V. I. Znamensky indicated for treatment in Matsesta: 1) diseases of the peripheral nervous system, -neuralgia, neuritis; 2) diseases of the central nervous system connected with disorders of the cardiovascular system, - hemiplegia and hemiparesis due to thrombosis and embolism; (treatment of acute forms of the mentioned diseases, it goes without saying, is contraindicated); 3) Luetic diseases,-vascular syphilis of the brain, lues cerebrospinalis, meningo-myelitis, tabes dorsalis incipiens and Luetic radiculitis (here; baths, giving increase of metabolism and excretions, make possible mercury treatment with impunity); 4) remnants of lethargic encephalitis.

Central and peripheral nervous system infection, immunity, and inflammation in the nonhuman primate model of lyme borreliosis

2001 ◽  
Vol 50 (3) ◽  
pp. 330-338 ◽  
Author(s):  
Andrew R. Pachner ◽  
Diego Cadavid ◽  
Gale Shu ◽  
Donna Dail ◽  
Sarah Pachner ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Lyme Borreliosis ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model

On the question of malarial lesions of the peripheral nervous system

1937 ◽  
Vol 33 (5) ◽  
pp. 566-576
Author(s):  
P. A. Badul
Keyword(s):  
Nervous System ◽  
Infectious Diseases ◽  
Peripheral Nervous System ◽  
Clinical Picture ◽  
Everyday Practice ◽  
Malarial Infection

Among the most common chronic infectious diseases, malaria with its various manifestations is indisputably one of the first places. In everyday practice, at every step we have to meet with one or another form of malaria, and we are so used to it that sometimes we notice only cases with a more definite clinical picture and often look through less clear, latent forms of malaria, suggesting a different etiology here. This situation is mainly due to the extremely large variety of malaria diseases, often occurring under the guise of other diseases. It is pertinent to recall the words of Dr. Bogoraz about some of the manifestations of malarial infection, which resembled surgical diseases: "Of the diseases known to science, only syphilis and tubercles can compete with swamp diseases in a variety and variety of manifestations."

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