Features of the course of peptic ulcer disease in children and adolescents

The aim of the research: evaluation of the peculiarities of anxiety in male patients with gastric ulcer and duodenal ulcer, which are sexual disorders. Materials and methods. The research is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer of duodenum and stomach in remission who have sexual disorders. The patients were divided into three groups: basic, comparative and referential. Was used C. Spielberger’s self-evaluation scale of situational and personal anxiety and M. Kurgan’s methodology. Results. It has been proven that the level of personal anxiety has a close correlation with the duration of peptic ulcer disease. Conclusion. The presence of peptic ulcer disease creates a certain basis for further psychological stress, similar to negative effect with the development of sexual disorders. Among the examined patients prevailed the somatized nature of depression.

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CLINICAL PROFILE AND RISK FACTORS FOR BENIGN PEPTIC ULCER DISEASE IN A TERTIARY CARE CENTRE IN THE SUBHIMALAYAN RANGES OF NORTH INDIA

10.36106/paripex/5002629 ◽

2020 ◽

pp. 1-3

Author(s):

Vishal Bodh ◽

Rajesh Sharma ◽

Brij Sharma

Keyword(s):

Risk Factors ◽

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Low Socioeconomic Status ◽

Low Socioeconomic ◽

Ulcer Disease ◽

H Pylori ◽

Upper Gastrointestinal

Background: To study the clinical profile and risk factors for benign peptic ulcer disease. Material and Methods: A total of 200 patients of peptic ulcer disease (PUD) diagnosed on upper gastrointestinal endoscopy were included. The socio-demographic profile, risk factors, clinical and endoscopic findings were recorded. Results: A total of 200 patients of peptic ulcer disease were included, out of which 168(84%) were males, while 32 (16%) were females. Most of the patients (61%) were between age 31-60 years with mean age of 47 years. Most of patients were farmers from rural areas and belonged to low socioeconomic status. History of smoking and alcohol intake was present in 106(53%) and 70( 35 %) patients respectively.Most common presenting complaints were epigastric pain and/or burning in 72 (36%) , followed by upper abdomen discomfort 70(35%) and upper gastrointestinal bleed 58(29%). Duodenal ulcer (DU) was present in 152 (76%), gastric ulcer(GU) in 30 (15%) while 18 (9%) had both DU and GU. Most of the patients had Forrest III ulcer 167 (83.5%) followed by Forrest IIc ulcer 13 (6.5%). H. pylori was detected by rapid urease test on endoscopic biopsy specimen in 156 (78 % ) of the total 200 patients of peptic ulcer disease. H. pylori was detected in 78.94 % case of DU, 60% case of GU and 100% cases of both DU and GU. Conclusion: PUD is a multifactorial health problem affecting almost all populations worldwide. . The major risk factors associated with PUD included tobacco and alcohol consumption besides low socioeconomic status, rural background and occupation of farming. Our findings indicate the substantial role of H. pylori and painkiller ingestion in the pathogenesis of PUD. Duodenal ulcer is most common type followed by gastric ulcer. Most had Forrest III ulcer followed by Forrest IIc.

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Rationale improve diagnosis of sexual disorders in patients with somatic profile for example gastric ulcer and duodenal

HEALTH OF WOMAN ◽

10.15574/hw.2016.116.60 ◽

2016 ◽

pp. 60-64

Author(s):

Y. Gurzhenko ◽

◽

V. Soroka ◽

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Depressive Mood ◽

Sexual Life ◽

Sexual Disorders ◽

Somatic Anxiety ◽

Ulcer Disease ◽

Low Level

The objective: The study and improvement of diagnosis of sexual disorders in patients of somatic profile, with ulcerative disease of the stomach (UDS) and peptic ulcer disease duodenal ulcer (DU). Patients and methods. For 3 years carried out a comprehensive examination and treatment of 130 patients with DU in remission and UDS in remission, which is observed sexual disorders; the first was 76 (58.5±4.3%) patients, second – 54 (41.5±4.3%); p<0.05. They represented the main group. The comparison group included 100 male patients with DU and UDS, which were also in remission, but did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. Also was used a reference group (control) of 20 healthy men. All groups were matched for age (average age in the major groups – 34.0±1.7 years in the control to 32.0±4.0 years), and the first two – and duration of ulcer (average period in the history of 6.9±0.7 years). Results. The frequency of manifestations of depression in patients with DU and UDS with sexual disorders identified parameters, among which reliably allocated to mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease was most prevalent somatic anxiety (32.0±4.6%), depressive mood (28.0±4.5%), capacity and activity (24.0±4.2%). The majority of patients with DU and UDS with sexual disorders (60,8±4,2%) recorded a high level of personal anxiety and almost equally often low to moderate (19,2±3,4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third - low (28.5±3.9%) and others (10.0 per cent), whereas among second - frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% - high). Conclusion. Justified the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which is to be included in the anamnestic and diagnostic method of two key issues, namely: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcer, sexual dysfunction, diagnosis.

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Peptic Ulcer Diseases

10.2310/tywc.1114 ◽

2018 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 76 references.

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Peptic Ulcer Diseases

10.2310/im.1114 ◽

2020 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 5 figures, 6 tables and 78 references.

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PREVALENCE OF H. PYLORI

The Professional Medical Journal ◽

10.29309/tpmj/2010.17.03.2536 ◽

2010 ◽

Vol 17 (03) ◽

pp. 431-439

Author(s):

MASOOD JAVED ◽

KHALID AMIN ◽

DILSHAD MUHAMMAD ◽

Aamir Husain ◽

Nasir Mahmood

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Protective Mechanism ◽

Skilled Workers ◽

Ulcer Disease ◽

Peptic Disease ◽

Number Of Patients ◽

H Pylori

Background: Acid peptic disease is a world wide problem among all the age groups and both sexes. Duodenal ulcer is common as compared to gastric ulcer. Its prevalence being 4:1 in USA & UK and 5:1 in Pakistan1,2,3. Etiology of peptic ulcer is almost certainly multi-factorial. Basic paradigm for ulcer disease is the imbalance between the digestive activity of acid and pepsin and the protective mechanism in place toresist mucosal digestion. Over the past few years a new line of thought has been evolved after isolating spiral campylobacter like organism from antral biopsy specimens. H pylori is now considered to be an important if not the only causative agent of gastritis and peptic ulcer disease. The dictum; No acid – No ulcer summarized the pathogenesis of peptic ulcer disease but new dictum seems to be; No H.pylori -No ulcer4,5, as over90% of Duodenal ulcer and 70% of Gastric ulcer patients are infected byH.Pylori6. Aim of the study was to evaluate the prevalence of H.pylori among Duodenal ulcer patients at Faisalabad District and its suburbs. Study Design: Descriptive Study. Period: From Mar 2008 to Oct 2008. Materials and Methods: 50 patients (40 Males, 10 Females) belonging to Faisalabad District and surrounding areas with upper gastrointestinal symptoms of acid peptic disease and endoscopy proved duodenal ulcer were subjected to gastric antral mucosal biopsies for evaluation of the H.Pylori status with the help of unease test and histological examination of biopsy specimen. Results: Epigastric pain was the most frequent symptom 90%. (46 out of 50 patients). 92% showed evidence of H. pylori infection. Maximum incidence of H. pylori was recordedin age group IV (46—55 years). Maximum number of patients was skilled workers (35 out of 50) 70%. 80 % of the patients belonged to lower and middle class. Percentage of H.pylori positivity was 89.1 % and 84.34 %. Conclusions: Acceptance of contributory role and high prevalence rate of H.pylori instigates us for addition of antimicrobial treatment to the conventional treatment with H2 Blockers and PPIs which is cost effectiveand alter the course of the disease.

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Current status of peptic ulcer disease in Port Harcourt metropolis, Nigeria

African Health Sciences ◽

10.4314/ahs.v20i3.50 ◽

2020 ◽

Vol 20 (3) ◽

pp. 1446-1451

Author(s):

Emeka Ray-Offor ◽

Kalanne Ada Opusunju

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Blood Group ◽

Hospital Admissions ◽

Current Status ◽

Gastric Ulcers ◽

Ulcer Disease ◽

Port Harcourt

Background: Epidemiological studies on peptic ulcer disease (PUD) have shown a recent decrease in hospital admissions in Western countries. Objective: This paper aimed to study the current status and risk factors of PUD in a Nigerian metropolis. Methods: A cross-sectional study of symptomatic patients at upper gastrointestinal (GI) endoscopy diagnosed with PUD from February 2014 to September 2019 at a referral endoscopy facility in Port Harcourt, Niger delta region of Nigeria. The variables studied included demographics, symptoms and duration, blood group, chronic non-steroidal anti-inflammatory (NSAID) use, smoking, endoscopic and histology findings. Statistical analysis was performed using SPSS version 20. Results: A total of 434 upper GI endoscopies were performed during the study period with thirty-one diagnosis of PUD made. The mean age of gastric ulcer (GU) and duodenal ulcer (DU) cases were 54.4 ± 20.2yrs and 48.1 ± 14.5yrs respectively (p = 0.367). GU to DU ratio was 1.4:1. H. pylori infection, chronic NSAID use and blood group O were seen in 7(22.5%), 8(25.8%) and 18(72.0%) respectively. Major indication in 21(67.7%) cases was gastrointestinal bleeding. Conclusion: There is a low diagnostic rate of PUD (6.7%) with pre-pyloric antral gastric ulcers as most common type and multifactorial aetiology. Keywords: Gastric ulcer; duodenal ulcer; endoscopy.

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Clinical features and prognosis in patients examined in medical and social expertise bureaus due to peptic ulcer disease

Kazan medical journal ◽

10.17816/kmj1786 ◽

2013 ◽

Vol 94 (1) ◽

pp. 124-127

Author(s):

A A Soshina ◽

V V Sergeeva ◽

T V Zinyaeva

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Features ◽

Dietary Habits ◽

Disease Risk ◽

Outlet Obstruction ◽

Moderate Activity ◽

Ulcer Disease

Aim. To study the clinical features, disability degree and expert examination results in patients with peptic ulcer disease. Methods. Acts of expertise of patients with peptic ulcer disease (gastric ulcer - 44 patients, duodenal ulcer - 47 patients) performed in medical and social expertise bureau on internal diseases of Saint-Petersburg, Russia from 2009 to 2011 were examined. Results. The most frequent peptic ulcer disease risk factors found in both of the groups were: predisposing diet and dietary habits (65.9% of patients with gastric ulcer, 78.7% of patients with duodenal ulcer), smoking (53.2 and 63.6% respectively), stress (70.5 и 87.2% respectively). In 10 (22.7%) patients with gastric ulcer and in 38 (80.9%) patients with duodenal ulcer peptic ulcer disease was associated with presence of Helicobacter pylori. There was a combination of predisposing factors in a majority of patients. In most of the cases a moderate activity and a long term of the disease was registered. Complications were diagnosed in 30 (68.2%) patients with gastric ulcer and in 27 (57.4%) patients with duodenal ulcer, most frequently: gastrointestinal bleeding - 19 (43.2%) and 12 (25.5%) patients respectively, gastric outlet obstruction - 10 (22.7%) and 9 (19.2%) patients respectively. According to the medical and social expertise algorithm 19 (43.2%) patients with gastric ulcer and 17 (36.2%) patients with duodenal ulcer were primarily rated as disability degree III, 3 (6.8%) and 2 (4.3%) patients respectively - as disability degree II. Contraindicated jobs and labor conditions, low labor, functional and social status were the reasons of setting up the status of disabled. Conclusion. The preliminary data show that peptic ulcer disease is not only a medical, but a major social problem, requiring novel treatment and prevention methods, as well as personal rehabilitation programs development and improvement.

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Features of men depressed patients with gastric ulcer and duodenal ulcer, with sexual disorders

HEALTH OF WOMAN ◽

10.15574/hw.2016.115.164 ◽

2016 ◽

pp. 164-170

Author(s):

Y.M. Gurzhenko ◽

◽

V.V. Soroka ◽

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Depressive Mood ◽

Sexual Disorders ◽

Somatic Anxiety ◽

Ulcer Disease ◽

Situational Anxiety ◽

Somatic Diseases

The objective: the evaluation of depressive state in men with peptic ulcer of stomach and duodenum, which have sexual disorders. Patients and methods. The study is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer disease duodenal ulcer in remission and gastric ulcer in remission who have sexual disorders; the first were 76 (58.5±4.3%) patients, the second – 54 (41.5±4.3%); p<0.05. They entered the main group. The comparison group consisted of 100 men with peptic ulcer disease duodenal ulcer and gastric ulcer that also in remission who did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. The creation of this group are motivated by the need to determine the characteristics of changes in the quality of life, psychological status between patients with these somatic diseases, but if not combined with sexual disorders. For this purpose was used the referential group consisted of 20 healthy men, the survey results of which complements the existing normalized values most approximate to this population. All groups were matched for age, and the first two – for the duration of peptic ulcer disease. Results. It is determined that the frequency of manifestations of depression in patients with peptic ulcer disease duodenal ulcer and gastric ulcer with sexual disorders identified parameters, among which stood out significantly mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease were most prevalent somatic anxiety (32.0±4.6%), depressive mood (28,0±4,5%), capacity and activity (24.0±4.2%). It is revealed that most duodenal ulcer and gastric ulcer with sexual disorders (60.8±4.2%) characterized by a high level of personal anxiety and almost equally often low to moderate (19.2±3.4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third – low (28.5±3.9%) and others (10.0 %) – high, whereas among second – frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% – high). Conclusion. It was confirmed the hypothesis of dependence between the presence of in patients with peptic ulcer disease various intensities of depression, mental tension, mainly situational anxiety and the development of sexual dysfunctions, as evidenced by the discovery in 14% of cases of erectile dysfunction. It was proven the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which – a mandatory inclusion in the medical history, as diagnostic method of two key parameters: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcers, sexual function disorders, psychological disorders, and depression.

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The role of microcirculation disorders in the pathogenesis of peptic ulcer disease

Kazan medical journal ◽

10.17816/kazmj62007 ◽

1982 ◽

Vol 63 (3) ◽

pp. 21-23

Author(s):

V. F. Bogoyavlenskiy ◽

A. G. Oparin ◽

R. M. Gazizov ◽

T. I. Rupasova

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Gastric Juice ◽

The State ◽

Healthy Individuals ◽

Ulcer Disease

In 60 healthy individuals and 85 patients with gastric ulcer and duodenal ulcer, the state of microcirculation of the conjunctiva of the eye and the level of glycoproteins in the gastric juice were studied. It has been shown that one of the reasons leading to a decrease in the level of mucins in gastric juice may be mucosal hypoxia caused by impaired microcirculation.

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