PREVALENCE OF H. PYLORI

Background: Acid peptic disease is a world wide problem among all the age groups and both sexes. Duodenal ulcer is common as compared to gastric ulcer. Its prevalence being 4:1 in USA & UK and 5:1 in Pakistan1,2,3. Etiology of peptic ulcer is almost certainly multi-factorial. Basic paradigm for ulcer disease is the imbalance between the digestive activity of acid and pepsin and the protective mechanism in place toresist mucosal digestion. Over the past few years a new line of thought has been evolved after isolating spiral campylobacter like organism from antral biopsy specimens. H pylori is now considered to be an important if not the only causative agent of gastritis and peptic ulcer disease. The dictum; No acid – No ulcer summarized the pathogenesis of peptic ulcer disease but new dictum seems to be; No H.pylori -No ulcer4,5, as over90% of Duodenal ulcer and 70% of Gastric ulcer patients are infected byH.Pylori6. Aim of the study was to evaluate the prevalence of H.pylori among Duodenal ulcer patients at Faisalabad District and its suburbs. Study Design: Descriptive Study. Period: From Mar 2008 to Oct 2008. Materials and Methods: 50 patients (40 Males, 10 Females) belonging to Faisalabad District and surrounding areas with upper gastrointestinal symptoms of acid peptic disease and endoscopy proved duodenal ulcer were subjected to gastric antral mucosal biopsies for evaluation of the H.Pylori status with the help of unease test and histological examination of biopsy specimen. Results: Epigastric pain was the most frequent symptom 90%. (46 out of 50 patients). 92% showed evidence of H. pylori infection. Maximum incidence of H. pylori was recordedin age group IV (46—55 years). Maximum number of patients was skilled workers (35 out of 50) 70%. 80 % of the patients belonged to lower and middle class. Percentage of H.pylori positivity was 89.1 % and 84.34 %. Conclusions: Acceptance of contributory role and high prevalence rate of H.pylori instigates us for addition of antimicrobial treatment to the conventional treatment with H2 Blockers and PPIs which is cost effectiveand alter the course of the disease.

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CLINICAL PROFILE AND RISK FACTORS FOR BENIGN PEPTIC ULCER DISEASE IN A TERTIARY CARE CENTRE IN THE SUBHIMALAYAN RANGES OF NORTH INDIA

10.36106/paripex/5002629 ◽

2020 ◽

pp. 1-3

Author(s):

Vishal Bodh ◽

Rajesh Sharma ◽

Brij Sharma

Keyword(s):

Risk Factors ◽

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Low Socioeconomic Status ◽

Low Socioeconomic ◽

Ulcer Disease ◽

H Pylori ◽

Upper Gastrointestinal

Background: To study the clinical profile and risk factors for benign peptic ulcer disease. Material and Methods: A total of 200 patients of peptic ulcer disease (PUD) diagnosed on upper gastrointestinal endoscopy were included. The socio-demographic profile, risk factors, clinical and endoscopic findings were recorded. Results: A total of 200 patients of peptic ulcer disease were included, out of which 168(84%) were males, while 32 (16%) were females. Most of the patients (61%) were between age 31-60 years with mean age of 47 years. Most of patients were farmers from rural areas and belonged to low socioeconomic status. History of smoking and alcohol intake was present in 106(53%) and 70( 35 %) patients respectively.Most common presenting complaints were epigastric pain and/or burning in 72 (36%) , followed by upper abdomen discomfort 70(35%) and upper gastrointestinal bleed 58(29%). Duodenal ulcer (DU) was present in 152 (76%), gastric ulcer(GU) in 30 (15%) while 18 (9%) had both DU and GU. Most of the patients had Forrest III ulcer 167 (83.5%) followed by Forrest IIc ulcer 13 (6.5%). H. pylori was detected by rapid urease test on endoscopic biopsy specimen in 156 (78 % ) of the total 200 patients of peptic ulcer disease. H. pylori was detected in 78.94 % case of DU, 60% case of GU and 100% cases of both DU and GU. Conclusion: PUD is a multifactorial health problem affecting almost all populations worldwide. . The major risk factors associated with PUD included tobacco and alcohol consumption besides low socioeconomic status, rural background and occupation of farming. Our findings indicate the substantial role of H. pylori and painkiller ingestion in the pathogenesis of PUD. Duodenal ulcer is most common type followed by gastric ulcer. Most had Forrest III ulcer followed by Forrest IIc.

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Peptic Ulcer Diseases

10.2310/tywc.1114 ◽

2018 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 76 references.

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Peptic Ulcer Diseases

10.2310/im.1114 ◽

2020 ◽

Author(s):

Edward A Lew

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Clinical Manifestations ◽

Muscularis Propria ◽

Gastric Ulcers ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

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Features of the course of peptic ulcer disease in children and adolescents

Kazan medical journal ◽

10.17816/kazmj62135 ◽

1985 ◽

Vol 66 (5) ◽

pp. 377-377

Author(s):

N. A. Cherkasova ◽

H. S. Bikbulatova ◽

V. N. Leonova

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Children And Adolescents ◽

Ulcer Disease

There were 26 patients with gastric ulcer and duodenal ulcer (17 boys, 9 girls) aged from 9 to 18 years under observation.

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Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

Diagnostic and Therapeutic Endoscopy ◽

10.1155/dte.4.135 ◽

1998 ◽

Vol 4 (3) ◽

pp. 135-139 ◽

Cited By ~ 2

Author(s):

Gh. Jeelani Romshoo ◽

G. M. Malik ◽

M. Youssuf Bhat ◽

Ab. Rashid rather ◽

Javaid Ahmad Basu ◽

...

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Healthy Volunteers ◽

Chronic Gastritis ◽

Healthy Population ◽

Ulcer Disease ◽

Antral Gastritis ◽

H Pylori

Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir.Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis.Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis).Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005).

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Screening and Preponderance of Peptic ulcer and its Contributing risk factors Among Basrah City Residents in Iraq

Current Drug Safety ◽

10.2174/1574886315666201013151640 ◽

2020 ◽

Vol 15 ◽

Author(s):

Ausama Jaccob ◽

Sheima Kadhim ◽

Amal Hassan ◽

Ali Mohsin ◽

Salah Muslim

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Teaching Hospital ◽

Antiplatelet Agents ◽

Peptic Ulcers ◽

Medication History ◽

Ulcer Disease ◽

Chronic Medication ◽

Number Of Patients ◽

H Pylori

Background: With the recent widespread use of over- the- counter drugs, there has been a noticeable increase in the occurrence of gastrointestinal discomfort and peptic ulcer disease. However, peptic ulcer is a highly complex disorder resulting from an imbalance between gstricdestructive and protective factors. Objectives: To identifyrisk factors of peptic ulcer disease. Methods: This study was organized at Al-Basra teaching hospital and Al Sader teaching hospital in Basrah city, Iraq. Medical records and questionnaires filled by patients undergoing diagnostic and therapeutic upper gastrointestinal endoscopies following their gastric discomfort complaints. Information related to patients, disease history and medication history during six months prior to endoscopy procedures was collected. Results: A total of 476 patients were identified, including 246 (51.7%) patients with endoscopically diagnosed peptic ulcers and 230 (48.3%) patients without peptic ulcers. The population was predominately male and there were significant differences between age groups.Smoking correlated with a high relative risk;however, alcohol drinking had no significant role as a causative factor. The most extensively used drugs by patients who complained of peptic ulcers are NSAIDs, iron supplements, corticosteroids, and antiplatelet agents. A small number of patients weretreated for hypertension and diabetes, which were correlated with peptic ulcer risks. The presence of H-pylori infections was significantly associated with peptic ulcer diagnosis. Conclusion: The risk of peptic ulcer disease appeared to increase with chronic medication use and smoking, which aggravatethe contributing risk by H-pylori infections.

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Features of Depressed State of Men with Sexual Disorders Based on Gastric Ulcer and Duodenal Ulcer

Family Medicine ◽

10.30841/2307-5112.5.2016.248843 ◽

2016 ◽

pp. 138-142

Author(s):

Yurii Gurzhenko ◽

Vasyl Soroka

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Research Evaluation ◽

Close Correlation ◽

Sexual Disorders ◽

Ulcer Disease ◽

Negative Effect ◽

Personal Anxiety

The aim of the research: evaluation of the peculiarities of anxiety in male patients with gastric ulcer and duodenal ulcer, which are sexual disorders. Materials and methods. The research is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer of duodenum and stomach in remission who have sexual disorders. The patients were divided into three groups: basic, comparative and referential. Was used C. Spielberger’s self-evaluation scale of situational and personal anxiety and M. Kurgan’s methodology. Results. It has been proven that the level of personal anxiety has a close correlation with the duration of peptic ulcer disease. Conclusion. The presence of peptic ulcer disease creates a certain basis for further psychological stress, similar to negative effect with the development of sexual disorders. Among the examined patients prevailed the somatized nature of depression.

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Rationale improve diagnosis of sexual disorders in patients with somatic profile for example gastric ulcer and duodenal

HEALTH OF WOMAN ◽

10.15574/hw.2016.116.60 ◽

2016 ◽

pp. 60-64

Author(s):

Y. Gurzhenko ◽

◽

V. Soroka ◽

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Peptic Ulcer Disease ◽

Depressive Mood ◽

Sexual Life ◽

Sexual Disorders ◽

Somatic Anxiety ◽

Ulcer Disease ◽

Low Level

The objective: The study and improvement of diagnosis of sexual disorders in patients of somatic profile, with ulcerative disease of the stomach (UDS) and peptic ulcer disease duodenal ulcer (DU). Patients and methods. For 3 years carried out a comprehensive examination and treatment of 130 patients with DU in remission and UDS in remission, which is observed sexual disorders; the first was 76 (58.5±4.3%) patients, second – 54 (41.5±4.3%); p<0.05. They represented the main group. The comparison group included 100 male patients with DU and UDS, which were also in remission, but did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. Also was used a reference group (control) of 20 healthy men. All groups were matched for age (average age in the major groups – 34.0±1.7 years in the control to 32.0±4.0 years), and the first two – and duration of ulcer (average period in the history of 6.9±0.7 years). Results. The frequency of manifestations of depression in patients with DU and UDS with sexual disorders identified parameters, among which reliably allocated to mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease was most prevalent somatic anxiety (32.0±4.6%), depressive mood (28.0±4.5%), capacity and activity (24.0±4.2%). The majority of patients with DU and UDS with sexual disorders (60,8±4,2%) recorded a high level of personal anxiety and almost equally often low to moderate (19,2±3,4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third - low (28.5±3.9%) and others (10.0 per cent), whereas among second - frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% - high). Conclusion. Justified the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which is to be included in the anamnestic and diagnostic method of two key issues, namely: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcer, sexual dysfunction, diagnosis.

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Prevalence of helicobacter pylori infection in patients with peptic ulcer disease at Kathmandu Model Hospital

Journal of Chitwan Medical College ◽

10.3126/jcmc.v8i4.23761 ◽

2018 ◽

Vol 8 (4) ◽

pp. 3-7

Author(s):

Rajesh Dhoj Joshi ◽

Sachin Khadka ◽

Deepak Man Joshi ◽

Arun Kadel ◽

Ganesh Dangal ◽

...

Keyword(s):

Duodenal Ulcer ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Rapid Urease Test ◽

Gi Endoscopy ◽

Ulcer Disease ◽

Upper Gi ◽

Urease Test ◽

Upper Gi Endoscopy ◽

H Pylori

Introduction: Endoscopic rapid urease test is a simple and most widely used test to detect the presence of urease in the gastric mucosa. Many studies have reported prevalence of H. pylori infection in relation to age, gender and site of ulcer. Therefore, this study was designed to determine the prevalence and significance of H. pylori in peptic ulcer disease. Methods: A retrospective review was carried out for patients with peptic ulcer disease who had undergone upper GI endoscopy in Department of Internal Medicine at Kathmandu Model Hospital. The records from January 2013 to December 2017 were analyzed. Any patient with previously diagnosed peptic ulcer, history of active bleeding, cancer and incomplete records were excluded. Peptic ulcer associated with H. pylori was diagnosed on the basis of endoscopic rapid urease test. Results: Among the 418 diagnosed case of peptic ulcer disease by upper GI endoscopy from Jan 2013 to Dec 2017, 213 tested positive for H. pylori by rapid urease test. Among the positive cases, over a half were males patients. Majority (23.9%) of the patients were in the age group of 35-44 years. Prevalence of H. pylori in duodenal ulcer was 51.6% followed by combined gastro-duodenal ulcer (26.8%) and gastric ulcer (21.6%). H. pylori was significantly associated with duodenal ulcer (p<0.0001). Conclusion: This study demonstrated relatively high prevalence of H. pylori infection in patients with duodenal ulcer who had undergone upper GI endoscopy.

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Peptic Disease in Elderly Patients

Canadian Journal of Gastroenterology ◽

10.1155/2000/697943 ◽

2000 ◽

Vol 14 (11) ◽

pp. 922-928 ◽

Cited By ~ 6

Author(s):

Neda Khaghan ◽

Peter R Holt

Keyword(s):

Peptic Ulcer ◽

Elderly Patients ◽

Peptic Ulcer Disease ◽

Elderly People ◽

Ulcer Disease ◽

Treatment Regimens ◽

Atypical Symptoms ◽

Peptic Disease ◽

Gastrointestinal Problems ◽

H Pylori

The increase in life expectancy demands that more attention be given to gastrointestinal problems, such as peptic ulcer disease, in elderly people. This review summarizes many of the physiological changes that have a role in peptic ulcer disease in elderly patients. HowHelicobacter pyloriinfection modifies the course of peptic disease is also reviewed. The clinical presentation of peptic diseases often differs in elderly people, and atypical symptoms are common. Accurate diagnosis requires aggressive endoscopic evaluation. Treatment regimens using H2receptor antagonists, proton pump inhibitors and regimens to eradicateH pylorimay also need to be altered in elderly patients.

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