Time test

1998 ◽  
Vol 79 (3) ◽  
pp. 227-231
Author(s):  
L. N. Tarasova ◽  
E. Yu. Savinykh ◽  
G. K. Platonov ◽  
L. L.N. Tonin ◽  
O. I. Rechkin
Keyword(s):  
Partial Thromboplastin Time ◽  
Raw Materials ◽  
Test Tube ◽  
Activated Partial Thromboplastin Time ◽  
Therapy Control ◽  
The World ◽  
Time Test

The data on standardization of the activated partial thromboplastin time test all over the world and in Russia are given. The method is used as a screening one and it is of importance for revealing disorders in the first coagulation phase (hemophilia diagnosis) and heparinotherapy control. Two lyophilized forms of partial thromboplastin made of cadaverine raw materials are developed. Their specificity in revealing hemophilia, therapy control by heparin fit for a year is confirmed. The diagnosticum of one of them is a basis of the kit for determining the activated partial thromboplastin time. The possibility of its use not only in performing the test by test tube methods but as well by semiautomatic and automatic machines.

scholarly journals A Multicenter Evaluation of an Activated Partial Thromboplastin Time Test, Cepho-Test

1977 ◽  
Author(s):  
D. Collen ◽  
H.C. Godal ◽  
P.M. Mannucci ◽  
I.M. Nilsson ◽  
C. Gilhuus-Moe ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Partial Thromboplastin Time ◽  
High Sensitivity ◽  
Mean Value ◽  
Activated Partial Thromboplastin Time ◽  
Satisfactory Precision ◽  
Time Test ◽  
The Mean ◽  
Aptt Reagent ◽  
Control Plasma

To compare the sensitivity and precision of the Activated Partial Thromboplastin Time (APTT) test Cephotest to that of APTT methods in current use, Cepho-test and current APTT method (Leuven and Milan: Locally modified Thrombofax/kaolin procedures; Malmoe: Automated APTT; Oslo: APTT of human brain/kaolin) were performed in parallel (20 tests) on lyophilized standard plasmas of 4 levels of factors VIII. The mean value (1 standard deviation) of Cephotest on Control Plasma Normal was 36.3 (2.21) s in Leuven, 31.7 (1.13) s in Oslo, 35.0 (1.36) s in Milan and 35.0 (1.16) s in Malmoe. The corresponding values of the local APTT methods were 50.2 (I.58) s, 34.5 (1.27) s, 51.9 (1.17) s and 38.8 (1.23) s, respectively. In Oslo, Milan and Malmoe, the sensitivity of Cephotest was superior to that of the local APTT reagent at all levels of factor VIII. In Leuven, the local APTT method had a higher ratio than Cephotest. There was no statistical significant differences between the standard deviation of Cephotest and the local APTT methods. The study indicates that Cephotest has a high sensitivity, satisfactory precision and is subjected to only minor interlaboratory variations.

scholarly journals Effects of Antibiotics on Haemostatic Parameters during Pregnancy

2021 ◽  
pp. 57-62
Author(s):  
Iyevhobu Kenneth Oshiokhayamhe ◽  
Amaechi R. A. ◽  
Turay A. A. ◽  
Okobi T. J. ◽  
Usoro E. R. ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Prothrombin Time ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Partial Thromboplastin Time ◽  
Health Centre ◽  
Activated Partial Thromboplastin Time ◽  
Erythrocyte Sedimentation ◽  
Time Test

An estimated 50,000 Nigerian women die each year from complications of pregnancy and childbirth, accounting for 10% of global estimates of pregnancy maternal death with about 2% resulting from drug induction. This cross-sectional study sets out to evaluate the Prothrombin time test (PT), activated partial thromboplastin time test (aPTT) Erythrocyte sedimentation rate (ESR), and Platelet count (PC) of pregnant women attending antenatal clinics at Oredo Health Centre in Benin City, Edo State. A total number of 130 subjects comprising 100 pregnant women and 30 non-pregnant women were recruited for the study. Prothrombin time (PT), Activated Partial Thromboplastin Time (APTT), Platelet count and Erythrocyte Sedimentation Rate (ESR) were studied using standard manual methods. The prothrombin time (sec) of the pregnant women 1st trimester (19.12±0.77b), 2nd trimester (19.90±1.02 b) and 3rd trimester (19.66±0.56 b), activated partial thromboplastin time (sec) 1st trimester (44.02±1.17 b), 2nd trimester (47.72±1.47 b) and 3rd trimester (45.88±1.10b), Erythrocyte sedimentation rate (mm/hr) 1st trimester (24.37±3.04 a), 2nd trimester (37.83±4.53 a) and 3rd trimester (43.25±5.24 a) and platelet count (X109/L) 1st trimester (248.29±23.18a), 2nd trimester (236.33±13.84 b) and 3rd trimester (239.10±16.07 a) were significantly higher than the prothrombin time (sec) 16.48±0.81 a, activated partial thromboplastin time (sec) 36.53±1.42 a, ESR (mm/hr) 29.83±4.14 a and platelet count (X109/L) 201±9.54 an of the non-pregnant women (p<0.05). The ESR (mm/hr) of the 3rd trimester (43.25±5.24) was observed to be significantly higher than that of the 1st trimester (24.37±3.04) and 2nd trimester (37.83±4.53) (p<0.05). Our investigation showed that antibiotics in pregnancy have a deleterious effect on PT, ESR, APTT and PC studied. We recommend that pregnant women should be given due attention throughout the course and events of pregnancy to prevent or reduce the risk of thrombotic episodes and possible disseminated intravascular coagulation (DIC) with resultant better maternity/child safety and health outcome and educated on the effects of antibiotics to pregnancy.

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