scholarly journals Cyclosporine use in “dry eye” syndrome

2019 ◽  
Vol 12 (3) ◽  
pp. 75-82
Author(s):  
Inna A. Riks
Keyword(s):  
Literature Review ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Dry Eye Syndrome ◽  
Eye Disease ◽  
Anti Inflammatory

This literature review focuses on the need for anti-inflammatory therapy for dry eye disease (DED). Causes of development and mechanisms of pathogenesis of DED are presented. Principles of action of various groups of anti-inflammatory medications, as well as recommendations for cyclosporine use of are described. The results of studies on cyclosporine efficacy are highlighted, principles of cyclosporin prescription in DED are listed.

Lágrimas artificiais no tratamento da doença do olho seco: uma revisão de literatura/ Artificial tears in the treatment of dry eye disease: a literature review

2021 ◽  
Vol 7 (7) ◽  
pp. 65512-65533
Author(s):  
Rafaela Montenegro Aires Sampaio ◽  
Anyssa Brilhante Aires Montenegro ◽  
Claudia Roberta de Andrade
Keyword(s):  
Literature Review ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tears

scholarly journals Physician Satisfaction with Anti-Inflammatory Topical Medications for the Treatment of Dry Eye Disease

2020 ◽  
Vol Volume 14 ◽  
pp. 931-938 ◽  
Author(s):  
Darrell E White ◽  
Yang Zhao ◽  
Hemalatha Jayapalan ◽  
Pattabhi Machiraju ◽  
Ramu Periyasamy ◽  
...  
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Physician Satisfaction ◽  
Eye Disease ◽  
Anti Inflammatory ◽  
Topical Medications

scholarly journals Treatment Satisfaction Among Patients Using Anti-Inflammatory Topical Medications for Dry Eye Disease

2020 ◽  
Vol Volume 14 ◽  
pp. 875-883 ◽  
Author(s):  
Darrell E White ◽  
Yang Zhao ◽  
Hemalatha Jayapalan ◽  
Pattabhi Machiraju ◽  
Ramu Periyasamy ◽  
...  
Keyword(s):  
Dry Eye ◽  
Treatment Satisfaction ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Anti Inflammatory ◽  
Topical Medications

Anti-inflammatory therapy for dry eye disease: rationale and strategy

2013 ◽  
pp. 243-243 ◽  
Author(s):  
John Sheppard ◽  
Niraj Shah ◽  
Giovanni DiSandro ◽  
Brianne Anthony
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Anti Inflammatory

scholarly journals GlicoPro, Novel Standardized and Sterile Snail Mucus Extract for Multi-Modulative Ocular Formulations. New Perspective in Dry Eye Disease Management

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2139
Author(s):  
Rita Mencucci ◽  
Giovanni Strazzabosco ◽  
Virginia Cristofori ◽  
Andrea Alogna ◽  
Daria Bortolotti ◽  
...  
Keyword(s):  
Dry Eye ◽  
Sodium Hyaluronate ◽  
Ophthalmic Solution ◽  
Dry Eye Disease ◽  
Mass Spectrometry Analysis ◽  
Corneal Epithelial Cell ◽  
Eye Disease ◽  
Corneal Cells ◽  
Anti Inflammatory

This study aimed to evaluate the mucoadhesive and regenerative properties of a novel lubricating multimolecular ophthalmic solution (GlicoPro®) extracted from snail mucus and its potential anti-inflammatory and analgesic role in the management of dry eye disease (DED). GlicoPro bio-adhesive efficacy was assessed using a lectin-based assay, and its regenerative properties were studied in a human corneal epithelial cell line. In vitro DED was induced in human corneal tissues; the histology and mRNA expression of selected genes of inflammatory and corneal damage biomarkers were analyzed in DED tissues treated with GlicoPro. A higher percentage of bio-adhesivity was observed in corneal cells treated with GlicoPro than with sodium hyaluronate-based compounds. In the scratch test GlicoPro improved in vitro corneal wound healing. Histo-morphological analysis revealed restoration of cellular organization of the corneal epithelium, microvilli, and mucin network in DED corneal tissues treated with GlicoPro. A significant reduction in inflammatory and ocular damage biomarkers was observed. High-performance liquid chromatography-mass spectrometry analysis identified an endogenous opioid, opiorphin, in the peptide fraction of GlicoPro. In conclusion, GlicoPro induced regeneration and bio-adhesivity in corneal cells; moreover, considering its anti-inflammatory and analgesic properties, this novel ophthalmic lubricating solution may be an innovative approach for the management of DED.

scholarly journals Current treatment modalities for dry eye disease

2021 ◽  
Vol 21 (1) ◽  
pp. 18-23
Author(s):  
E.B. Tatarnikova ◽  
◽  
O.I. Krivosheina ◽  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Current Treatment ◽  
Dry Eye Disease ◽  
Treatment Modalities ◽  
Eye Disease ◽  
Published Data ◽  
Eye Drops ◽  
Anti Inflammatory

For many years, dry eye disease (DED) is a common ophthalmic condition associated with ocular surface damage and loss of homeostasis of the tear film. The key pathogenic factors of DED are tear film instability and tear hyperosmolarity, ocular surface inflammation and damage, and neurosensory alterations. Current treatment for DED consists of non-medical therapies, tear substitutes, anti-inflammatory agents, and surgical procedures. These treatments improve disease course and quality of life. However, these treatments are largely palliative as long-term (and even life-long) installation of eye drops is required. Modern and effective treatments for DED are needed. This paper reviews domestic and foreign published data on the important therapies for DED and novel tools to promote symptom relief. These data are required for the understanding of the pharmacological effects of various drug classes prescribed for DED and early treatment initiation. Keywords: dry eye disease, tear replacement therapy, anti-inflammatory treatment, surgery, hyaluronic acid, preservatives. For citation: Tatarnikova E.B., Krivosheina O.I. Current treatment modalities for dry eye disease. Russian Journal of Clinical Ophthalmology. 2021;21(1):18–23. DOI: 10.32364/2311-7729-2021-21-1-18-23.

scholarly journals Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1698
Author(s):  
Ana López-Machado ◽  
Natalia Díaz-Garrido ◽  
Amanda Cano ◽  
Marta Espina ◽  
Josefa Badia ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ex Vivo ◽  
Visual Disturbance ◽  
Nasolacrimal Duct ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Lipid Film ◽  
Anti Inflammatory

Dry eye disease (DED) is a high prevalent multifactorial disease characterized by a lack of homeostasis of the tear film which causes ocular surface inflammation, soreness, and visual disturbance. Conventional ophthalmic treatments present limitations such as low bioavailability and side effects. Lactoferrin (LF) constitutes a promising therapeutic tool, but its poor aqueous stability and high nasolacrimal duct drainage hinder its potential efficacy. In this study, we incorporate lactoferrin into hyaluronic acid coated liposomes by the lipid film method, followed by high pressure homogenization. Pharmacokinetic and pharmacodynamic profiles were evaluated in vitro and ex vivo. Cytotoxicity and ocular tolerance were assayed both in vitro and in vivo using New Zealand rabbits, as well as dry eye and anti-inflammatory treatments. LF loaded liposomes showed an average size of 90 nm, monomodal population, positive surface charge and a high molecular weight protein encapsulation of 53%. Biopharmaceutical behaviour was enhanced by the nanocarrier, and any cytotoxic effect was studied in human corneal epithelial cells. Developed liposomes revealed the ability to reverse dry eye symptoms and possess anti-inflammatory efficacy, without inducing ocular irritation. Hence, lactoferrin loaded liposomes could offer an innovative nanotechnological tool as suitable approach in the treatment of DED.

scholarly journals Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

2019 ◽  
Vol 8 (8) ◽  
pp. 1227 ◽  
Author(s):  
Yu-Kai Kuo ◽  
I-Chan Lin ◽  
Li-Nien Chien ◽  
Tzu-Yu Lin ◽  
Ying-Ting How ◽  
...  
Keyword(s):  
Literature Review ◽  
Dry Eye ◽  
Treatment Options ◽  
Tear Film ◽  
Global Scale ◽  
Dry Eye Disease ◽  
Consumer Electronics ◽  
Eye Disease ◽  
Comprehensive Literature Review ◽  
And Gender

Dry eye disease (DED) has become common on a global scale in recent years. There is a wide prevalence of DED in different countries based on various ethnicities and environment. DED is a multifactorial ocular disorder. In addition to advanced age and gender, such factors as living at high altitude, smoking, pterygium, prolonged use of consumer electronics or overingesting of caffeine or multivitamins are considered to be the major risk factors of DED. We report the DED epidemiology in Taiwan firstly in this article. According to the pathophysiological factors and changes inthe composition of the tear film in DED, it can be categorized into several subtypes, including lipid anomaly dry eye, aqueous tear deficiency, allergic and toxic dry eye among others. Each subtype has its own cause and disease management; therefore, it is important for ophthalmologists to identify the type through literature review and investigation. The management of DED, relies not only on traditional medications such as artificial tears, gels and ointments, but also newer treatment options such as acupuncture, SYL1001, and nanomedicine therapy. We also conducted a comprehensive literature review including common subtypes and treatment of DED. Clearly, more clinical trials are needed to assess the efficacy and safety of the various treatments and common subtypes of DED.

Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease

Nanoscale ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 5580-5594 ◽  
Author(s):  
Yu-Jia Li ◽  
Li-Jyuan Luo ◽  
Scott G. Harroun ◽  
Shih-Chun Wei ◽  
Binesh Unnikrishnan ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Rapid Recovery ◽  
Eye Disease ◽  
Eye Drops ◽  
Oxidative Treatment ◽  
Dual Functional ◽  
Anti Inflammatory

Poly(catechin)-capped gold nanoparticles carrying amfenac exhibit superior anti-inflammatory/anti-oxidative properties for rapid recovery from dry eye.

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