scholarly journals Influence of congenital heart disease-caused hypoxia on intrathymic development of t-lymphocytes in children of first year of life

2019 ◽  
Vol 36 (4) ◽  
pp. 46-54
Author(s):  
N. P. Loginova ◽  
V. A. Chetvertnykh ◽  
G. A. Khromtsova ◽  
R. M. Shekhmametyev ◽  
L. A. Chetvertnykh
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Immunological Methods ◽  
First Year ◽  
First Year Of Life ◽  
Degree Of Severity

Aim. To study the influence of hypoxia, caused by congenital heart disease, on the intrathymic development of T-lymphocytes and provision of the organism with T-cellular resource in children with cardiac pathology of different degree of severity. Materials and methods. The paper presents the results of complex immunomorphological study of the thymus in children of the first year of life (n = 129) with congenital heart diseases. Hystochemical and immunological methods were used to assess the influence of congenital heart disease-caused hypoxia on the functional status of thymus regarding provision of a child with T-lymphocytes. Results. It was established that the degree of severity of congenital heart disease correlated with the degree of suppression of T-lymphocyte pool formation. During the first year of life, proliferative activity of thymocytes (assessed by Ki-67 expression) in the thymus falls, being the reason of decrease in the number of CD3+ thymocytes. In conditions of marked hypoxia (blue type of defect) the process of T-lymphocyte differentiation is inhibited that causes preservation of less mature forms of thymocytes. As a result, hypoxia is the reason of proliferation suppression and thymocyte differentiation, influencing subpopulation composition of the cells. Thus, insufficient quantity of thymic migrants enters the peripheral blood that confirms low functional activity of thymus regarding provision of the organism with T-cellular resource. Conclusions. No doubt, it can be the cause of immunodeficient state and reduced formation of adaptive immunity in this category of children.

scholarly journals Dynamic electroneurostimulation in the prevention of broncho-pulmonary complications with children of the first year of life suffering from congenital heart diseases in the early post-operating period

2019 ◽  
Vol 18 (1) ◽  
pp. 4-8
Author(s):  
Artavazd A. Pnjoyan ◽  
Yuliya M. Borzunova ◽  
Andrey A. Fedorov ◽  
Elena V. Negodaeva
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Postoperative Period ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Pulmonary Complications ◽  
Control Group ◽  
First Year ◽  
Hospitalization Period ◽  
First Year Of Life

The purpose of the study is to substantiate the use of dynamic electronic neurostimulation as a means of preventing broncho-pulmonary complications with children of the first year of life with congenital heart disease in the early postoperative period. Material and methods. There have been observed 82 children operated on congenital heart disease at an average age of 7.6 2.0 months old. By simple randomization, the patients were divided into two groups. Children who received the dynamic electronic neurostimulation procedure from the first day against the background of basic drug therapy were in the 1st group (40 people). The 2nd group (42 people) included patients who were treated only with basic medication. Results. The result analysis of the study showed a statistically significant effect in the use of dynamic electronic neurostimulation compared to the control group. By evaluating the length of the patients stay in hospital after the operative treatment, significant differences have also been obtained. Thus, the patients in the control group stayed in the unit for an average of 14.6 0.3 days, while the patients in the group where dynamic electronic neurostimulation was used in combination with basic therapy had a hospitalization period of 13.4 0.4 days (p 0.05). The use of DENS allowed to reduce the frequency of complications associated with the bronchopulmonary system starting from 34 days of the postoperative period. Thus, in the control group, 5 (11%) children showed pneumonia, 13 (30%) showed atelectasis or dystelectasis, 23 (55%) showed tracheobronchitis, while in the main group 2 (5%), 6 (15%) and 11 (27.5%) children, respectively. Conclusion. The obtained results of the work show the expediency of including dynamic electronic neurostimulation in the complex of medical and rehabilitation measures in early post-operative period with infants suffering from congenital heart disease.

scholarly journals Parental experience of the neuromotor development of children with congenital heart disease: an exploratory qualitative study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elena Mitteregger ◽  
Martina Wehrli ◽  
Manuela Theiler ◽  
Jana Logoteta ◽  
Irina Nast ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Qualitative Study ◽  
Motor Development ◽  
Congenital Heart ◽  
Healthcare Professionals ◽  
Qualitative Content Analysis ◽  
First Year ◽  
First Year Of Life ◽  
Neuromotor Development

Abstract Background Children with severe congenital heart disease (CHD) are a group of children at risk for neurodevelopmental impairments. Motor development is the first domain to show a delay during the first year of life and may significantly contribute to parental concerns, stress, and difficulties in early child-parent attachment. Thus, the aim of the study was to better understand the wishes and concerns of parents of children with CHD and explore their experience of their children’s neuromotor development in the first year of life. Methods In this qualitative study, fourteen families were recruited. Their children were aged 1–3 years and had undergone open heart surgery within the first 6 months of life. Semi-structured interviews were audio-recorded and transcribed. The data was explored within an expert group, and a qualitative content analysis was conducted using VERBI MAXQDA software 2020. The study was conducted in accordance with the COREQ checklist. Results Parents of children with CHD reported several burdens and needs. Parental burdens concerned the child’s motor development, their own physical and psychological strain, and difficulties in communication with healthcare professionals. The needs, parents reported included supporting their child’s motor development, a medical coordinator, and better communication between healthcare professionals and parents. During the first phase of their children’s illness, parents underwent a dynamic transitional phase and expressed the need to rely on themselves, to trust their children’s abilities, and to regain self-determination in order to strengthen their self-confidence. Conclusions It is essential to involve parents of children with CHD at an early stage of decision-making. Parents are experts in their children and appreciate medical information provided by healthcare professionals. Interprofessional teamwork, partnering with parents, and continuous support are crucial to providing the best possible care for children and their families. Family-centred early motor intervention for CHD children might counteract the effect of parental overprotection and improve children’s motor development and thus strengthen child-parent interaction. In future work, we aim to evaluate a family-centred early motor intervention for children with CHD developed on the basis of this qualitative study. Trial registration Not applicable.

scholarly journals Updates in Congenital Heart Disease: Can Outcomes Improve?

2019 ◽  
Vol 36 (S 02) ◽  
pp. S22-S28
Author(s):  
Gerard R. Martin ◽  
Russell R. Cross ◽  
Lisa A. Hom ◽  
Darren Klugman
Keyword(s):  
Intensive Care Unit ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
First Year ◽  
Cardiac Intensive Care Unit ◽  
Cardiac Intensive Care ◽  
First Year Of Life ◽  
Pulse Oximetry Screening

AbstractDespite numerous advances in medical and surgical management, congenital heart disease (CHD) remains the number one cause of death in the first year of life from congenital malformations. The current strategies used to approach improving outcomes in CHD are varied. This article will discuss the recent impact of pulse oximetry screening for critical CHD, describe the contributions of advanced cardiac imaging in the neonate with CHD, and highlight the growing importance of quality improvement and safety programs in the cardiac intensive care unit.

CONGENITAL HEART DISEASE: INCIDENCE IN THE FIRST YEAR OF LIFE

1988 ◽  
Vol 128 (2) ◽  
pp. 381-388 ◽  
Author(s):  
RALPH G. GRABITZ ◽  
MICHEL R. JOFFRES ◽  
RUTH L. COLLINS-NAKAI
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Disease Incidence ◽  
First Year ◽  
First Year Of Life

scholarly journals Congenital Heart Disease and Its Impact on the Development of Anastomotic Strictures after Reconstruction of Esophageal Atresia

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Pernilla Stenström ◽  
Martin Salö ◽  
Magnus Anderberg ◽  
Einar Arnbjörnsson
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Esophageal Atresia ◽  
Congenital Heart ◽  
First Year ◽  
Retrospective Case ◽  
Anastomotic Strictures ◽  
First Year Of Life ◽  
Severe Congenital Heart Disease

Background. The aim was to explore if severe congenital heart disease (CHD) influenced the need for dilatation of anastomotic strictures (AS) after the repair of esophageal atresia (EA). Methods. A retrospective case-control study was conducted examining AS in children with EA and Gross type C. The spectra of CHD and cardiac interventions were reviewed. The frequency of dilatations of AS during the first year following EA reconstruction was compared between children with and without severe CHD requiring cardiac surgery during their first year of life. Endoscopic signs of stricture were an indication for dilatation. Results. Included in the follow-up for AS were 94 patients who had EA reconstructions, of whom 10 (11%) children had severe CHD requiring surgery during the first year including 19 different cardiac interventions. In total, 38 patients needed dilatation of esophageal AS, distributed as six (60%) with severe CHD and 32 (38%) without severe CHD (p=0.31). Conclusion. Severe CHD was present in 11% of children with EA. Esophageal AS developed in 60% children with concomitant CHD, but although high, it did not reach statistical difference from children without CHD (38%).

Sign in / Sign up

Export Citation Format

Share Document