scholarly journals Rational perioperative antibiotic prophylaxis for open damages of brush in children

2020 ◽  
Vol 10 (4) ◽  
pp. 419-428
Author(s):  
Ivan I. Gordienko ◽  
Natalya A. Tsap
Keyword(s):  
Antibiotic Prophylaxis ◽  
Complete Blood Count ◽  
Clinical Signs ◽  
Clinical Results ◽  
Blood Analysis ◽  
Hand Injuries ◽  
Tubular Bone ◽  
Short Term ◽  
Perioperative Antibiotic Prophylaxis ◽  
Rational Algorithm

Introduction. Today, hand injuries are one of the most pressing and common problems in modern traumatology worldwide. Results obtained statistically indicate a fairly high frequency of hand injuries, including open ones. Often, an incorrect prescription of antibiotics in the form of unjustified antibiotic therapy in the absence of direct indications is done. Aim. This study aimed to develop a rational algorithm for perioperative antibiotic prophylaxis for open hand injuries in children based on experimental and clinical research. Materials and methods. The study was divided into two phases: experimental and clinical. The experiment was carried out on 60 sexually mature, outbred guinea pigs. During the experiment, the analysis of clinical signs of inflammation, complete blood count and biochemical blood analysis, spiral computed tomography, and morphological study of the consolidation zone were performed. The clinical part of the work is based on the analysis of surgical treatment results of 120 children with open hand injuries, which were divided into two groups: the main group that included 50 children receiving treatment according to the experimentally developed perioperative antibiotic prophylaxis (PAP) algorithm, and the comparison group included 70 children receiving a perioperative course of antibiotics from 0 to 7 days, without a well-defined algorithm. Results. In the analysis of clinical results, laboratory, radiation, and morphological methods of studying the experimental material, the absence of antibiotic prophylaxis in open fractures of small tubular bones with a 90% probability was found to entail pro-inflammatory complications in the area of postoperative wound; however, a one day short-term course of PAP will prevent complications and will not have statistically significant differences with a longer course of three days. Discussion. Results of a clinical study proved the effectiveness of the developed algorithm and showed better results in early and late postoperative period in comparison with the chaotic prescription of antibacterial drugs without a clear algorithm; however, no statistically significant differences in the level of postoperative complications were found. Conclusion. On the basis of an experimental model of an open fracture of the tubular bone, osteosynthesis and various courses of antibiotic prophylaxis has proven that a short-term course of PAP within 24 h is the most optimal one, and achieving minimal risks of inflammatory complications and better anatomical and functional outcomes in clinical practice.

scholarly journals The antibiotic prophylaxis algorithm for open hand injuries in children. Experimental study.

2019 ◽  
Vol 12 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Ivan Ivanovich Gordienko ◽  
Semen Aleksandrovich Borisov ◽  
Natalya Aleksandrovna Tsap
Keyword(s):  
Experimental Study ◽  
Antibiotic Prophylaxis ◽  
Heart Valves ◽  
New Technologies ◽  
Rapid Development ◽  
Hand Injuries ◽  
Tubular Bone ◽  
Antibacterial Drugs ◽  
Surgical Interventions ◽  
Perioperative Antibiotic Prophylaxis

Relevance. The rapid development of new technologies in surgery has opened up broad horizons for the implementation of complex surgical interventions. At the same time, the duration of operations was reduced, the invasiveness decreased, and broad operational approaches began to go into the past. However, the infectious process in the area of operative action remains an acute problem of surgery today. Infections of the surgical area (OSIW) are infections that develop within 30 days after surgery or within a year after installing the prosthesis (heart valves, blood vessels or joint).Aim. Develop an algorithm for perioperative antibiotic prophylaxis for open tubular fractures based on experimental research.Methods. An experimental study was conducted on 60 adult guinea pigs, which created a model of an open femur fracture. All animals were divided into 3 groups depending on the timing of the introduction of antibacterial drugs. The degree of local manifestations was assessed according to the developed scale from 0 to 2 points, where 0 is the total absence of inflammatory manifestations, and 2 points is their maximum manifestation. The signs of inflammation were also evaluated in the general clinical blood test.Results. During the experiment it was revealed that the introduction of antibacterial drugs for open fractures of tubular bones is necessary for prophylactic purposes. An increase in the timing of the introduction of antibiotics to three days or more is not rational, since there are no significant differences compared with a shorter course of antibiotic prophylaxis. Conclusions. Experimental perioperative antibiotic prophylaxis (PAP) on the model of an open fracture of the tubular bone indicated the possibility of introducing the PAP algorithm for open hand injuries in children.

scholarly journals Clinical, Laboratorial and Image Aspects of a Perforated Pyloric Ulcer Secondary to Nonsteroidal Anti-Inflammatory Use in a Cat

2020 ◽  
Vol 48 ◽  
Author(s):  
Tadeu Basualdo Junior ◽  
Ester Mercado Cedron Benetti ◽  
Julia Lanfredi Tonin ◽  
Márcio Virgílio Figueiredo da Silva ◽  
Joyce Maira De Araújo ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Tumor Staging ◽  
Clinical Status ◽  
Clinical Signs ◽  
Abdominal Distension ◽  
Exploratory Laparotomy ◽  
Blood Analysis ◽  
Self Medication ◽  
Delay In Diagnosis ◽  
Post Surgery

Background: Inappropriate use of drugs for veterinary patients represents a common problem at clinical practice. Nonsteroidal anti-inflammatories are one of these misused drugs and may lead to clinical status of challenging diagnosis. Adverse effects for patients submitted to its incorrect use may include simple cases such as pharmacological gastroenteritis to severe acute renal failure or perforated gastroenteric ulcers with no pathognomonic clinical signs. The objective of this report was to describe a case of a perforated pyloric ulcer secondary to prolonged use of meloxicam in a cat with its clinical, laboratorial and image aspects from the moment of suspicion until the diagnosis.Case: An 8-year-old female feline was attended at the Veterinary Hospital of the Dom Bosco Catholic University, with main complaint being a mammary nodule with recent ulceration. Tumor staging and pre-surgical blood analysis were performed previous to total unilateral mastectomy. Eleven days post-surgery the patient was brought for suture removal, but it was observed stupor, moderate dehydration (estimated 10%), 36.7ºC rectal temperature, heart rate at 100 beats/min, respiratory rate at 60 breaths/min, 40 mg/dL blood glucose, icterus and abdominal distension with tympany at percussion (fluid wave test was negative). Anamnesis revealed the possible use of meloxicam for 10 days. The first suspicion was sepsis, with enteric gas secondary to infection. Due to no classical signs of peritoneum effusion and possible severe enteric distension, abdominocentesis was not immediate performed. Complete blood count and serum biochemistry revealed a marked band leukocytosis associated with renal injury, supporting the first sepsis suspicion. Abdominal radiography revealed radiodensity of diffuse aspect at ventral topography but no evidence of marked enteric distension that would justify tympany. Abdominal ultrasound identified effusion predominantly hyperechogenic with hyperechogenic mesentery, indicative of peritonitis. A diagnostic abdominocentesis was performed revealing a dense yellow-green effusion with high suspicion of being gastroenteric liquid. Exploratory laparotomy was not authorized by the owner and the patient was submitted to euthanasia due to the bad prognosis. Macroscopic necropsy was performed and a perforated pyloric ulcer was identified along with an impregnated mesentery with a green-brown color (peritonitis), closing the diagnosis.Discussion: The importance of reiteration regarding veterinary prescription orientation, especially for feline patients, is evidenced. Along the indiscriminate over-the-counter sale of veterinary drugs, self-medication prior to veterinary consultation is usual even for ongoing assisted patients. Considering the unspecific clinical signs that patients with perforated gastroenteric ulcers may present, the diagnosis may be challenging when no complementary image exams are immediate available. The stuporous mental state inhibiting possible manifestation of abdominal discomfort, absence of positive fluid wave test and tympany at percussion which prohibited a secure abdominocentesis could have led to a delay in diagnosis, if not for image support. Considering the emergency status of these patients, early diagnosis is crucial, therefore clinicians should have precaution when approaching patients with possible perforated gastroenteric ulcers and trust clinical history, even when classical signs of abdominal effusion are not present.

scholarly journals Perioperative Antibiotic Prophylaxis in Open Hand Injuries in Children

Doctor Ru ◽  
2019 ◽  
Vol 160 (5) ◽  
pp. 34-37 ◽  
Author(s):  
I.I. Gordienko ◽  
◽  
N.A. Tsap ◽  
◽  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Hand Injuries ◽  
Perioperative Antibiotic Prophylaxis

scholarly journals Pelvic osteosarcoma ressection in a bitch: case report

2009 ◽  
Vol 61 (1) ◽  
pp. 35-41 ◽  
Author(s):  
B.A. Rodrigues ◽  
C. Faraco ◽  
R. Oliveira ◽  
S. Cheuiche ◽  
F.S. Teixeira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Weight Bearing ◽  
Clinical Signs ◽  
Bone Cancer ◽  
Clinical Results ◽  
Surgical Removal ◽  
Short Term ◽  
Painful Mass

An osteosarcoma involving the pelvis was diagnosed in a 9-year-old neutered Labrador bitch. The clinical signs manifested by the patient before surgical removal of the tumor included urinary difficulty, dyschezia, and inconstant non-weight-bearing on the hindlimbs. These signs were linked to the localization of the tumor, which was identified as a firm and painful mass of the size of an orange in the caudal abdomen. The favorable short term clinical results after surgery and carboplatin chemotherapy showed that the association of these approaches can be employed to manage discomfort inflicted by tumor and, therefore improve the quality of life of patient of bone cancer.

Assessment of the quality of life in the treatment approaches of patients with the comorbid course of arterial hypertension and metabolic disorders aimed at reducing cardiovascular risk

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
V Zlatkina ◽  
V Shkapo ◽  
A Nesen ◽  
T Starchenko
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Arterial Hypertension ◽  
Metabolic Disorders ◽  
Clinical Signs ◽  
Blood Analysis ◽  
Sf 36 ◽  
Artery Disease

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Cardiovascular diseases (CVD) remain the leading cause of premature death worldwide. According to epidemiological studies CVD prevention is highly effective. A 50% reduction in mortality from coronary artery disease (CAD) is associated with exposure to risk factors and only 40% with improved treatment. Purpose.  To assess the quality of life (QOL) in patients with arterial hypertension (AH) and metabolic disorders, to establish its impact on therapy effectiveness. We examined 280 patients with AH and comorbidity - 171 women and 109 men aged 45-75 years. Along with AH, all patients had comorbidities: 72.6 % suffered from coronary artery disease (CAD), 10.5% after myocardial infarction (MI), 35 % had clinical signs of heart failure (HF), 22, 1% - type 2 diabetes mellitus (t2DM), 27.4% - chronic kidney disease (CKD). Methods. Anthropometry, blood pressure (BP) measurement, immunoassay (C-reactive protein), biochemical blood analysis (lipid, carbohydrate metabolism parameters, QOL determination (questionnaire Sf-36). Results. In patients with comorbidity of pathologies (presence of AH, t2DM, CKD, CAD, obesity), there was a decrease in assessments in almost all indicators of QOL, and especially significant limitations in the performance of daily activities due to both physical and mental state. Conclusion. The degree of AH in patients with t2DM decreased QOL of physical activity, role-physical functioning, pain and general health, reflecting physical health, as well as mental health, including vitality, social activity, role emotional functioning. T2DM in patients with AH significantly worsens QOL of this category of patients as in physical component summary and mental component summary. The indicators of QOL are significantly affected by the duration of t2DM, as well as the degree of compensation. Achievement of the target BP levels in patients with AH with t2DM shows an improvement in a number of QOL parameters and makes it possible to recommend the Sf-36 questionnaire as a criterion for the effectiveness of the therapy.

Short-term Antibiotic Prophylaxis and Prostatectomy*

1981 ◽  
Vol 53 (4) ◽  
pp. 339-343 ◽  
Author(s):  
P. J. R. SHAH ◽  
GORDON WILLIAMS ◽  
M. CHAUDARY
Keyword(s):  
Antibiotic Prophylaxis ◽  
Short Term
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