scholarly journals 1,5-Benzothiazepinone and arylazepinone dipeptide mimetics as local constraints in peptidomimetic design

2018 ◽  
Author(s):  
Robin Van Den Hauwe ◽  
Olivier Van der Poorten ◽  
Steven Ballet ◽  
Emilie Eiselt ◽  
Phillipe Sarret ◽  
...  
Keyword(s):  
2019 ◽  
Vol 12 (3) ◽  
pp. 331-348 ◽  
Author(s):  
Gillian Howell ◽  
Lesley Pruitt ◽  
Laura Hassler

In the phenomenon of the divided city – urban environments partitioned along ethno-religious lines as a result of war or conflict – projects seeking to bring segregated people together through community music activities face many operational and psychological obstacles. Divided cities are politically sustained, institutionally consolidated, and relentlessly territorialized by competing ethno-nationalist actors. They are highly resistant to peacebuilding efforts at the state level. This article uses an urban peacebuilding lens (peacebuilding reconceptualized at the urban scale that encompasses the spatial and social dimensions of ethno-nationalist division) to examine the work of community music projects in three divided cities. Through the examples of the Pavarotti Music Centre in Mostar, Bosnia-Herzegovina, the Mitrovica Rock School in Mitrovica, Kosovo, and Breaking Barriers (a pseudonym) in Belfast, Northern Ireland, we consider the context-specific practices and discourses that are deployed to navigate the local constraints on inter-communal cooperation, but that also contribute to the broader goal of building peace. We find that music-making is a promising strategy of peacebuilding at the urban scale, with both functional and symbolic contributions to make to the task of transforming an ethnoscape into a peacescape.


2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Jesse Verschuere ◽  
Tom Decroo ◽  
Dara Lim ◽  
Jean-Marie Kindermans ◽  
Chea Nguon ◽  
...  

Development ◽  
1989 ◽  
Vol 105 (2) ◽  
pp. 191-211 ◽  
Author(s):  
F. Iftode ◽  
J. Cohen ◽  
F. Ruiz ◽  
A.T. Rueda ◽  
L. Chen-Shan ◽  
...  

The shape of a Paramecium is determined by the organization of its cortex which constitutes most of the cell cytoskeleton. These structures and networks are organized in relation to the approx. 4000 ciliary basal bodies present at the surface. Each basal body is the centre of a polarized and asymmetrical cortical unit. At the whole-cell level, all units are tandemly arranged in parallel rows and form a defined asymmetrical pattern with dorsoventral and anteroposterior polarities. During division, the cortex is the site of the major morphogenetic processes. In order to analyse how the surface pattern and the shape of the cell are reconstructed at each division, we have used specific immunological and cytological probes to map, in space and time, the reorganization of each of the major cytoskeletal cortical components: basal bodies and microtubules, kinetodesmal fibres, epiplasm and outer lattice. This cytological dissection demonstrates that the surface of the dividing cell is progressively invaded by morphogenetic waves which successively and individually trigger the duplication, assembly or reorganization of each structure and which all spread from the same epicentre (oral apparatus and fission furrow) with the same shape. Furthermore, the response of units to the morphogenetic waves depends on their position on the cell. It thus appears that despite the structural local constraints within units, the development of surface pattern is controlled in an integrated manner by transcellular signals.


Author(s):  
Adam Smale ◽  
Jukka-Pekka Heikkilä

The design and implementation of a globally integrated e-HRM system within a multinational corporation (MNC) requires different parties to reach some form of agreement on which HR processes must be standardised and which must be locally adapted. In this respect, the IT-based integration of HRM presents an intriguing setting in which to study micro-political behaviour during HRM integration, that is, how parties promote their own interests and the strategies they use during negotiations. Accordingly, the study’s aims were to identify those issues which generated the greatest degree of conflict during the IT-based integration of HRM, the key actors involved and the resources that were deployed during negotiations. A longitudinal, in-depth case study approach was used, and followed the integration of a global e-HRM system in the Finnish subsidiary of a large European-owned MNC over a period of nearly two years. Qualitative data was collected via semi-structured interviews with key subsidiary HR personnel and was complemented with company documentation. The findings indicate that the key areas of conflict were system design, the standardised use of English, and grey areas of HR policy. Three key parties were identified as being involved in subsequent negotiations. These parties utilised a range of negotiation resources including business case logic, technical know-how, internal benchmarking, local constraints and ignorance.


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