scholarly journals TESTICULAR MORPHOLOGY OF ALBINO RAT; WITHDRAWAL EFFECTS OF CHRONIC ANDROGENIC ANABOLIC STEROID

2016 ◽  
Vol 23 (03) ◽  
pp. 343-349 ◽  
Author(s):  
Dr. Muhammad Mazhar Hijazi ◽  
Dr. Muhammad Rashid Ahmed ◽  
Dr. Hafiz Syed Imran Ul Haq ◽  
Syed Naeemul Hassan Naqvi ◽  
Rehana Parveen
2016 ◽  
Vol 23 (03) ◽  
pp. 343-349
Author(s):  
Muhammad Mazhar Hijazi ◽  
Muhammad Rashid Ahmed Ahmed ◽  
Hafiz Syed Imran Ul Haq ◽  
Syed Naeemul Hassan Naqvi ◽  
Rehana Parveen

Withdrawal effects of chronic androgenic anabolic steroid on hormonal andtesticular morphology were studied .Forty five male albino rats were divided into 1) Control 2)Chronic group and 3) Withdrawal group. Testoviron was injected at a dose of 400mg/kg bodyweight intramuscularly once in two weeks for 14 weeks, and then drug was withdrawan foranother 14 weeks. Testes were removed and fixed in 10% formalin and processed. Followingwithdrawal of AAS, testicular and relative testicular weight was restored to control. Increasedtubular count also returned near to normal while decreased diameter of seminiferous tubules,thickness of germinal epithelium, count and diameter of leydig cells were also restored nearto normal in withdrawal group when compared with the chronically treated group. Histologicalobservations also revealed that degenerated spermatogenic cells were returned to their normalappearance and oedematous vacuoles were reduced. Moreover, decreased level of reproductivehormones, i.e. FSH, LH and testosterone also returned to control level in withdrawal group.These results indicated that chronic AAS has substantial harmful effects on hormonal andtesticular morphology. However, these adverse effects gradually restored to normal followingwithdrawal from AAS.


Cancer ◽  
1977 ◽  
Vol 40 (4) ◽  
pp. 1761-1764 ◽  
Author(s):  
Luis Hernandez-Nieto ◽  
Miguel Bruguera ◽  
Juan A. Bombi ◽  
Luis Camacho ◽  
Cirilo Rozman

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87106 ◽  
Author(s):  
Danilo S. Bocalini ◽  
Abram Beutel ◽  
Cássia T. Bergamaschi ◽  
Paulo J. Tucci ◽  
Ruy R. Campos

1987 ◽  
Vol 15 (4) ◽  
pp. 357-361 ◽  
Author(s):  
Markku Alen ◽  
Paavo Rahkila ◽  
Matti Reinilä ◽  
Reijo Vihko

2001 ◽  
Vol 29 (1) ◽  
pp. 49-66 ◽  
Author(s):  
Fred Hartgens ◽  
Wouter D. Van Marken Lichtenbelt ◽  
Spike Ebbing ◽  
Niels Vollaard ◽  
Gerard Rietjens ◽  
...  

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