scholarly journals Epidemiology of Age-Related Macular Degeneration in the Republic of Bashkortostan (Clinical and Statistical Analisys of the “Ural Eye and Medical Study”)

2019 ◽  
Vol 16 (1S) ◽  
pp. 137-141
Author(s):  
T. R. Gilmanshin
Keyword(s):  
Early Stage ◽  
Population Characteristics ◽  
Age Related Macular Degeneration ◽  
Disease Stage ◽  
Urban Residents ◽  
Rural Residents ◽  
Medical Study ◽  
Age Related ◽  
Republic Of Bashkortostan ◽  
The Republic

Purpose. Analysis of the AMD prevalence in the Republic of Bashkortostan, depending on the disease stage, gender and the nature of the respondent settlement. Methods. A population-based study of Republic of Bashkortostan residents “Ural Eye and Medical Study” was conducted on the basis of the State Budget Institution “Ufa Research Institute of Eye Diseases of the Academy of Sciences of the Republic of Bashkortostan”. There were 5899 participants in the study, 2581 (43.7 %) were men, 3318 (52.3 %) were women. There were 2501 urban residents (42.3 %), rural residents — 3398 (59.7 %). Study design: cross-sectional one-stage analytical research. Statistical data analysis was performed using the IBM SPSS statistic application package. Results. AMD was diagnosed in 550 individuals (11.5 %): early stage — in 392 (7.9 %), intermediate — in 119 (2.4 %), later — in 39 individuals (0.8 %). The number of men with AMD was 210 (10.8 %), women — 340 (11.4 %). Among men, an early stage was observed in 144 (7.4 %), intermediate — in 52 (2.7 %), later — in 14 individuals (0.7 %). Among women, early AMD was observed in 248 (8.3 %), intermediate — in 67 (2.2 %), later — in 25 individuals (0.8 %). The number of urban residents with AMD was 194 individuals (9.7 %), rural residents — 356 individuals (12.1 %). At the same time, among urban residents, an early stage was observed in 138 (6.9 %), intermediate — in 43 (2.2 %), and later stage — in 13 individuals (0.6 %). Among rural residents, the early stage of AMD is in 254 (8.6 %), intermediate — in 76 (2.6 %), later — in 26 individuals (0.9 %). Conclusion. The prevalence of AMD in the Republic of Bashkortostan according to the “Ural Eye and Medical Study” is 11.1 %, which exceeds the global figure. The lack of prevalence of the AMD among women (among women — 11.4 %, among men — 10.8 %) is a distinctive feature for this region. The prevalence of this pathology among rural residents (12.1 %), among urban (9.7 %). The influence of population characteristics for the prevalence of AMD in regions with a peculiar ethno-cultural composition, geographical features.

scholarly journals On the Epidemiology of Diabetic Retinopathy in the Republic of Bashkortostan

2019 ◽  
Vol 4 (4) ◽  
pp. 66-69
Author(s):  
M. M. Bikbov ◽  
Т. R. Gilmanshin ◽  
R. M. Zainullin ◽  
K. I. Kudoyarova
Keyword(s):  
Diabetic Retinopathy ◽  
Population Based ◽  
Urban Residents ◽  
Entire Study ◽  
Medical Study ◽  
Republic Of Bashkortostan ◽  
Study Population ◽  
Diabetic Population ◽  
The Republic ◽  
Over 40 Years

Aim. To study of the prevalence of diabetes and diabetic retinopathy in the Republic of Bashkortostan among people over 40 years of age, depending on the stage of the disease, gender and the nature of the settlement of the respondents. Materials and methods. A population-based study “Ural Eye and Medical Study” on the basis of the Ufa Research Institute of Eye Diseases covered 5899 people, of whom 2581 (43.7 %) were men, 3318 (52.3 %) were women. There were 2501 (42.3 %) urban residents, 3398 (59.7 %) rural residents. Statistical data analysis was performed using the IBM SPSS Statistic application package.Results. According to the study, diabetes was observed in 687 people, among them – 221 (32.2 %) men, 466 (67.8 %) women; urban residents – 378 (55.0 %) people, rural – 309 (45.0 %) people. The prevalence of diabetes is 11.6 %. Diabetic retinopathy was observed in 102 people (27 men – 26.5 %, and 75 women – 73.5 %), urban residents – 60 (58.8 %), rural – 42 (41.2 %). The prevalence of diabetic retinopathy among the entire study population was 2.1 %, or 14.8 % in the diabetic population. Conclusions. The prevalence of diabetes in the Republic of Bashkortostan according to the results of the Ural Eye and Medical Study was 11.6 % among people over 40 years old. The prevalence of diabetic retinopathy in the general population of the republic was 2.1 %, and in the population with diabetes it was 14.8 %, which is, in general, less than the global average.

Risk factors for the development of age-related cataracts in the Republic of Bashkortostan

2020 ◽  
pp. 22-23
Author(s):  
G.Z. Israfilova ◽  
◽  
T.R. Gilmanshin ◽  
R.M. Zainullin ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Age Related ◽  
Republic Of Bashkortostan ◽  
The Republic

scholarly journals Efficacy of Psychiatric Treatment to Treat a Specific Phobia of Intravitreal Injections in a Patient with Neovascular Age-Related Macular Degeneration

2021 ◽  
pp. 48-56
Author(s):  
Atsuta Ozaki ◽  
Hisashi Matsubara ◽  
Masahiko Sugimoto ◽  
Manami Kuze ◽  
Mineo Kondo ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Macular Edema ◽  
Psychiatric Treatment ◽  
Early Stage ◽  
Behavioral Therapy ◽  
Specific Phobia ◽  
Age Related Macular Degeneration ◽  
Intravitreal Injections ◽  
Anti Vegf ◽  
Age Related

Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is essential for the treatment of macular diseases such as wet age-related macular degeneration and macular edema. Although continued treatment is needed to maintain good vision, some patients cannot continue such injections for various reasons, including specific phobias. Here, we report a case of a patient with a specific phobia of intravitreal injections who could resume treatment after undergoing combined drug and cognitive-behavioral therapy (CBT). A 74-year-old Japanese man diagnosed with retinal angiomatous proliferation by fluorescein angiography and indocyanine green angiography was treated with intravitreal anti-VEGF injection. However, at 8 months after the first treatment, he became difficult to treat because of a phobia of injections. He was treated with photodynamic therapy, but his macular edema did not improve. After a psychiatric consultation, he was diagnosed with a specific phobia of intravitreal injections. Combined drug and CBT enabled him to resume receiving intravitreal injections. This case demonstrates that a specific phobia of intravitreal injections may benefit from combined drug and CBT. In this regard, some patients with high anxiety and fear of intravitreal injections should be referred to a psychiatrist at an early stage.

scholarly journals Prevalence of age-related macular degeneration in the Republic of Ireland

2015 ◽  
Vol 99 (8) ◽  
pp. 1037-1044 ◽  
Author(s):  
Kwadwo Owusu Akuffo ◽  
John Nolan ◽  
Jim Stack ◽  
Rachel Moran ◽  
Joanne Feeney ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Republic Of Ireland ◽  
Age Related ◽  
The Republic

Epilutein for Early-Stage Age-Related Macular Degeneration: A Randomized and Prospective Study

2017 ◽  
Vol 58 (4) ◽  
pp. 231-241 ◽  
Author(s):  
Raimondo Forte ◽  
Lucia Panzella ◽  
Ida Cesarano ◽  
Gilda Cennamo ◽  
Thomas Eidenberger ◽  
...  
Keyword(s):  
Prospective Study ◽  
Macular Degeneration ◽  
Early Stage ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Photoreceptor layer thinning is an early biomarker for age-related macular degeneration development: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data

2021 ◽  
Author(s):  
Seyedeh Maryam Zekavat ◽  
Sayuri Sekimitsu ◽  
Yixuan Ye ◽  
Hongyu Zhao ◽  
Tobias Elze ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Early Stage ◽  
Age Related Macular Degeneration ◽  
Retinal Layer ◽  
Polygenic Risk Score ◽  
Uk Biobank ◽  
Polygenic Risk ◽  
Age Related ◽  
Clinical Biomarker

AbstractIntroductionAge-related macular degeneration (AMD) is a blinding condition for which there is currently no early-stage clinical biomarker. AMD is characterized by thinning of the outer retina and drusen formation leading to thickening of the Bruch’s membrane and RPE complex, but the timing between these two events, as well as the role of genetic variants in these processes, are unclear. Here, we jointly analyzed genomic, electronic health record, and optical coherence tomography (OCT) data across 44,823 individuals from the UK Biobank to characterize the epidemiological and genetic associations between retinal layer thicknesses and AMD.MethodsThe Topcon Advanced Boundary Segmentation algorithm was used for automated retinal layer segmentation. We associated 9 retinal layer thicknesses with prevalent AMD (present at enrollment) in a logistic regression model, and with incident AMD (diagnosed after enrollment) in a Cox proportional hazards model. Next, we tested the association of AMD-associated genetic alleles, individually and as a polygenic risk score (PRS), with retinal layer thicknesses. All analyses were adjusted for age, age2, sex, smoking status, and principal components of ancestry.ResultsPhotoreceptor segment (PS) thinning was observed throughout the lifespan of individuals analyzed and accelerated at age 45, while retinal pigment epithelium and Bruch’s membrane complex (RPE+BM) thickening started after age 57. Each standard deviation (SD) of PS thinning and RPE+BM thickening were associated with prevalent AMD (PS: OR 1.37, 95% CI 1.25-1.49, P=2.5×10−12; RPE+BM: OR=1.34, 95% CI 1.27-1.41, P=8.4×10−28) and incident AMD (PS: HR 1.35, 95% CI 1.23-1.47, P=3.7×10−11; RPE+BM: HR 1.14, 95% CI 1.06-1.22, P=0.00024). An AMD polygenic risk score (PRS) was associated with PS thinning (Beta -0.21 SD per 2-fold genetically increased risk of AMD, 95% CI -0.23 to -0.19, P=2.8×10−74), and its association with RPE+BM was U-shaped (thinning with AMD PRS<92nd percentile and thickening with AMD PRS>92nd percentile suggestive of drusen formation). The loci with strongest support were AMD risk-raising variants CFH:rs570618-T, CFH:10922109-C, and ARMS2/HTRA1:rs3750846-C on PS thinning, and SYN3/TIMP3:rs5754227-T on RPE+BM thickening.ConclusionsEpidemiologically, PS thinning precedes RPE+BM thickening by decades, and is the retinal layer most strongly predictive of future AMD risk. Genetically, AMD risk variants are associated with decreased PS thickness. Overall, these findings support PS thinning as an early-stage clinical biomarker for future AMD development.

scholarly journals Prevalence and associated factors of cataract and cataract-related blindness in the Russian Ural Eye and Medical Study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mukharram M. Bikbov ◽  
Gyulli M. Kazakbaeva ◽  
Timur R. Gilmanshin ◽  
Rinat M. Zainullin ◽  
Ildar F. Nuriev ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Population Based ◽  
Age Related Macular Degeneration ◽  
Urban Region ◽  
High Density Lipoproteins ◽  
Eligibility Criterion ◽  
Age Group ◽  
Medical Study ◽  
Age Related ◽  
Low Prevalence

Abstract To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclear, cortical, subcapsular cataract and any cataract was 38.0% [95% confidence interval (CI) 36.6, 39.3], 14.5% (95% CI 13.5, 15.5), 0.6% (95% CI 0.4, 0.8) and 44.6% (95% CI 43.2, 46.0), respectively. A higher prevalence of nuclear cataract was associated with older age [odds ratio (OR) 1.10; 95% CI 1.10, 1.11], the female sex (OR 1.27; 95% CI 1.08, 1.50), urban region (OR 2.00; 95% CI 1.71, 2.33), a low educational level (OR 0.93; 95% CI 0.88, 0.98), a high diastolic blood pressure (OR 1.01; 95% CI 1.001, 1.02), a low serum concentration of high-density lipoproteins (OR 0.91; 95% CI 0.84, 0.98), more smoking package years (OR 1.01; 95% CI 1.01, 1.02), chronic kidney disease (OR 1.02; 95% CI 1.10, 1.03), a short axial length (OR 0.93; 95% CI 0.86, 0.99), and a low prevalence of age-related macular degeneration (OR 0.72; 95% CI 0.57, 0.92). The prevalence of previous cataract surgery conducted in 354/5885 individuals (6.0%; 95% CI 5.4, 6.6) increased from 0.4% (95% CI 0.0, 1.0) in the age group of 40–45 years to 37.6% (95% CI 30.9, 44.4) in the age group of 80 + years. Cataract was the cause of moderate-to-severe vision impairment in 109 (1.8%) individuals and of blindness in three (0.05%) individuals. The prevalence of cataract and cataract-related MSVI and blindness were relatively high; subsequently, the prevalence of previous cataract surgery was relatively low in this population from Russia.

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