scholarly journals Clinical Aspects of Bacterial Corneal Ulcer Prolonged Course, the Role of Herpes Viruses in Its Pathogenesis, Treatment

2019 ◽  
Vol 16 (1S) ◽  
pp. 40-44
Author(s):  
V. V. Neroev ◽  
L. A. Katargina ◽  
L. A. Kovaleva ◽  
G. I. Krichevskaya ◽  
N. V. Balatskaya
Keyword(s):  
Corneal Ulcer ◽  
Human Herpesvirus ◽  
Clinical Aspects ◽  
Herpesvirus Type ◽  
Corneal Ulcers ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Simplex Virus

Purpose: to study the role of human herpesviruses (HHV) in the pathogenesis of prolonged bacterial corneal ulcers. Patients and methods. 117 patients with bacterial corneal ulcer were examined. Two groups were identified: a favorable course-with duration of bacterial corneal ulcer epithelialization for 17 days (62 people) and a prolonged course with a persistent ulcer more than 17 days (55 people). Blood samples (n = 117) and scrapes from corneal ulcer (n = 117) were investigated in polymerase chain reaction (PCR) for the presence of deoxyribonucleic acid (DNA) of Herpes simplex virus (HSV1, 2), Epstein-Barr virus (EBV), Human herpesvirus type 6, 7 (HHV-6, HSV-7). Results. The HSV1, 2 and EBV genomes were detected in the cornea significantly more often in BCU of prolonged course compared with a favorable course (HSV1, 2 p = 0.012; EBV p = 0.012), and HHV-6 was detected not only in the cornea (p = 0.000), but also and in blood (p = 0.007). In patients with HHV DNA in corneal scarps and/or blood, after resorption of purulent infiltrate, corneal epithelialization was absent, and the use of antiherpetic drugs allowed to reduce the completion time of BCU epithelialization. Conclusion. The role of HHV-6, EBV, HSV 1, 2 in the pathogenesis of bacterial corneal ulcer of protracted course was revealed. The expediency of examination of patients with bacterial corneal ulcer on HHV is shown, a method of treatment is proposed, including antiherpetic therapy, which makes it possible to prevent the development of a protracted course.

scholarly journals Production of IgM antibody to HHV6 in reactivation and primary infection

1990 ◽  
Vol 104 (2) ◽  
pp. 289-296 ◽  
Author(s):  
J. D. Fox ◽  
P. Ward ◽  
M. Briggs ◽  
W. Irving ◽  
T. G. Stammers ◽  
...  
Keyword(s):  
Blood Donors ◽  
Human Herpesvirus ◽  
The Other ◽  
Cmv Infection ◽  
Igg Antibody ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Simplex Virus

SUMMARYThe cross-reaction of HHV6 antibody with that to the other herpesviruses was studied in 96 blood donors whose sera were tested for IgG antibody to human herpesvirus type 6 (HHV6), cytomegalovirus (CMV), Epstein–Barr virus (EBV), varicella zostervirus (VZV) and herpes simplex virus (HSV). No correlation was found between IgG antibody to HHV6 and that to any of the other herpesviruses in these individuals. Antibodies to HHV6 and CMV were measured in patients undergoing documented serological responses to HHV6. Eleven cases of primary HHV6 infection associated with roseola infantum in babies, 1 of whom suffered from gastroenteritis as well as pyrexia and rash, are reported. Three cases of HHV6 reactivation, 1 in a 3-year-old child and 2 in adults, 1 of whom simultaneously underwent a primary CMV infection are also reported. Our results suggest that indirect immunofluorescence is a specific way of measuring HHV6 antibody, that HHV6 IgG and IgM can be detected in the absence of antibody to CMV and that HHV6 IgM is present both in primary HHV6 infections and in reactivations.

scholarly journals Epstein–Barr Virus-Induced Acute Hepatitis, Pancreatitis, and Pneumonitis in a Young Immunocompetent Adult: A Case Report

2021 ◽  
Author(s):  
Elias Fiani ◽  
Rafca Challita ◽  
Hanaa Badawaki ◽  
Khaled Soukarieh ◽  
Melissa Kyriakos Saad ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Rare Complication ◽  
Human Herpesvirus ◽  
B Cell Lymphoma ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Ebv Infection ◽  
Human Herpesvirus Type ◽  
Epstein Barr

Epstein–Barr virus (EBV) is a common herpes virus (human herpesvirus type 4) that usually manifests as infectious mononucleosis or persists asymptomatically for life. EBV can also be associated with different types of malignancy such as T cell lymphoma, B cell lymphoma, Hodgkin lymphoma, and oropharyngeal squamous cell and nasopharyngeal carcinoma. Pneumonia is a very rare complication of EBV infection, but it has been reported to occur even in the absence of mononucleosis. This article highlights the case of 35-year-old female who developed acute pancreatitis and acute respiratory failure related to EBV infection. The patient progressively recovered on antiviral therapy and steroids.

scholarly journals Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division

2010 ◽  
Vol 84 (21) ◽  
pp. 11175-11188 ◽  
Author(s):  
Toomas Silla ◽  
Andres Männik ◽  
Mart Ustav
Keyword(s):  
Transcriptional Activation ◽  
Human Herpesvirus ◽  
Bovine Papillomavirus ◽  
Transactivation Domain ◽  
Mitotic Chromosomes ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Multiple Copies ◽  
Epstein Barr

ABSTRACT Effective segregation of the bovine papillomavirus type 1 (BPV1), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated human herpesvirus type 8 (KSHV) genomes into daughter cells is mediated by a single viral protein that tethers viral genomes to host mitotic chromosomes. The linker proteins that mediate BPV1, EBV, and KSHV segregation are E2, LANA1, and EBNA1, respectively. The N-terminal transactivation domain of BPV1 E2 is responsible for chromatin attachment and subsequent viral genome segregation. Because E2 transcriptional activation and chromatin attachment functions are not mutually exclusive, we aimed to determine the requirement of these activities during segregation by analyzing chimeric E2 proteins. This approach allowed us to separate the two activities. Our data showed that attachment of the segregation protein to chromatin is not sufficient for proper segregation. Rather, formation of a segregation-competent complex which carries multiple copies of the segregation protein is required. Complementation studies of E2 functional domains indicated that chromatin attachment and transactivation functions must act in concert to ensure proper plasmid segregation. These data indicate that there are specific interactions between linker molecules and transcription factors/complexes that greatly increase segregation-competent complex formation. We also showed, using hybrid E2 molecules, that restored segregation function does not involve interactions with Brd4.

scholarly journals A case of abdominal-pelvic infiltrative lesion of chronic active Epstein–Barr virus infection

2020 ◽  
Vol 18 ◽  
pp. 205873922093688
Author(s):  
Tianjiao Xue ◽  
Huan Ye ◽  
Fang Li ◽  
Chengyu Luo ◽  
Shumei Liu ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Human Herpesvirus ◽  
Epstein Barr Virus Infection ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein–Barr virus (EBV) belongs to a subfamily of herpesviruses, also known as human herpesvirus type 4. EBV is widely distributed in the population, with a high infection rate of 90%. EBV infects mainly B lymphocytes, stimulates cell proliferation and transformation and even causes cancer. In recent years, it has been found that it can also infect T lymphocytes, epithelial cells and natural killer (NK) cells and can cause related diseases. EBV infection can cause a variety of clinical symptoms and clinical manifestations, which brings some confusion to clinical diagnosis and easily leads to missed diagnosis and misdiagnosis. In this article, we report a case of EBV-induced severe abdominal and pelvic infection, which eventually led to death.

scholarly journals Human Herpesvirus and the Immune Checkpoint PD-1/PD-L1 Pathway: Disorders and Strategies for Survival

2021 ◽  
Vol 9 (4) ◽  
pp. 778
Author(s):  
Takayuki Murata
Keyword(s):  
Cell Death ◽  
Immune System ◽  
Programmed Cell Death ◽  
Immune Checkpoint ◽  
Human Herpesvirus ◽  
Barr Virus ◽  
Programmed Cell Death 1 ◽  
Epstein Barr ◽  
Simplex Virus ◽  
Human Herpesviruses

The immune system has evolved as a complex and efficient means of coping with extrinsic materials, such as pathogens and toxins, as well as intrinsic abnormalities, such as cancers. Although rapid and timely activation of the immune system is obviously important, regulated downregulation of the system is almost as significant as activation to prevent runaway immunity, such as allergies and hypercytokinemia. Therefore, the immune checkpoint programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is beneficial for the host. On the other hand, pathogens have evolved to evade host immunity by taking advantage of the PD-1/PD-L1 pathway. This review is focused on human herpesviruses, such as herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein–Barr virus (EBV), which cause various types of disorders, and their relationships with the PD-1/PD-L1 pathway. Understanding such relationships will be useful for developing preventative and therapeutic methods for disorders caused by herpesviruses.

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