scholarly journals Predictors of Quality of Life after Liver Transplant

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Joey Wu ◽  
Archita Desai, MD
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
General Population ◽  
Liver Transplant ◽  
Liver Diseases ◽  
Chronic Liver ◽  
University Hospital ◽  
Chronic Liver Diseases ◽  
The Impact

Background and Hypothesis: The impact of chronic liver diseases on patients and their family member is often understated and understudied. Chronic liver diseases can sometimes progress to a need for Liver transplant (LT). While recent studies have described quality of life (QOL) at different stages of liver disease, the impact of the patient’s QOL in LT survivors has not been examined. The importance of studying QOL in patients is due to its effect on the survivorship of LT recipients. We hypothesize that QOL in LT patients is lower than the general population. Our aim was to describe predictors of QOL in a well-described cohort of LT patients. Methods: Patients were enrolled at the Digestive and Liver Disease Liver clinic at Indiana University Hospital. All patients over the age of 18 were approached, if patients consented to the study, they were then enrolled during their liver follow up visit. The PROMIS survey was administered on an iPad and completed during the clinic visit. Survey were then scored and analyzed. Results: The T-scores for post liver transplant patients are lower in physical function, anxiety and depression, but higher in general life satisfaction compared to the general population. LT recipients have similar T-scores in Fatigue, Sleep disturbance, ability to participate in social activities, and pain interference compared to the general population. Conclusion and Potential Impact: Previous diagnosis of PBC, HCC, diagnosis of depression, household income, insurance status, Charlson Comorbid Index and number of non-transplant related medications have the highest association with quality of life. Further enrollment is needed to increase the power of the study. However, this can inform physicians the importance to taking these factors in to consideration in order to improve the QOL in LT recipients.

Health-related quality of life in chronic liver disease: the impact of type and severity of disease

2001 ◽  
Vol 96 (7) ◽  
pp. 2199-2205 ◽  
Author(s):  
Zobair M Younossi ◽  
Navdeep Boparai ◽  
Lori Lyn Price ◽  
Michelle L Kiwi ◽  
Marilyn McCormick ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Health Related Quality ◽  
Severity Of Disease ◽  
Related Quality ◽  
Health Related ◽  
The Impact

scholarly journals Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1576 ◽  
Author(s):  
Daisuke Uchida ◽  
Akinobu Takaki ◽  
Atsushi Oyama ◽  
Takuya Adachi ◽  
Nozomu Wada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Viral Hepatitis ◽  
Liver Diseases ◽  
Chronic Viral Hepatitis ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Anti Cancer ◽  
The Impact

Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular carcinoma. As anti-viral treatment progresses, the impact of NAFLD is increasing. NAFLD can coexist with chronic viral hepatitis and exacerbate its progression. Oxidative stress has been recognized as a chronic liver disease progression-related and cancer-initiating stress response. However, there are still many unresolved issues concerning oxidative stress, such as the correlation between the natural history of the disease and promising treatment protocols. Recent findings indicate that oxidative stress is also an anti-cancer response that is necessary to kill cancer cells. Oxidative stress might therefore be a cancer-initiating response that should be down regulated in the pre-cancerous stage in patients with risk factors for cancer, while it is an anti-cancer cell response that should not be down regulated in the post-cancerous stage, especially in patients using anti-cancer agents. Antioxidant nutrients should be administered carefully according to the patients’ disease status. In this review, we will highlight these paradoxical effects of oxidative stress in chronic liver diseases, pre- and post-carcinogenesis.

scholarly journals PGI36 Relationship Between Clinical Severity and Health Related Quality of Life in Chronic Liver Diseases

2012 ◽  
Vol 15 (7) ◽  
pp. A332 ◽  
Author(s):  
L. Scalone ◽  
P.A. Cortesi ◽  
R. Ciampichini ◽  
S. Okolicsanyi ◽  
M. Rota ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Clinical Severity ◽  
Health Related Quality ◽  
Chronic Liver Diseases ◽  
Related Quality ◽  
Health Related

scholarly journals Quality of life in patients with chronic hepatitis C

2011 ◽  
Vol 139 (3-4) ◽  
pp. 165-169
Author(s):  
Sladjana Pavic ◽  
Dragan Delic ◽  
Jasmina Simonovic ◽  
Neda Svirtlih
Keyword(s):  
Quality Of Life ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Healthy Population ◽  
Chronic Liver Diseases ◽  
Chronic Hepatitis C Patients

Introduction. Hepatitis C virus often causes chronic liver disease reducing physical, mental and social functions in these patients. Objective. The aim of this investigation was analysis of the quality of life in chronic hepatitis C patients compared to patients with other chronic liver diseases and healthy population, as well as investigation of the influence of socio-demographic factors on the quality of life in patients with chronic hepatitis C. Methods. A generic Short Form-36 (SF-36) questionnaire and Chronic Liver Diseases Questionnaire (CLDQ) were used in this prospective study for the investigation of the quality of life in 160 patients (100 patients with chronic hepatitis C, 30 patients with chronic hepatitis B, 30 patients with non-viral chronic liver diseases) and 50 healthy controls. Results. Reduced quality of life was noted in patients with chronic hepatitis C patients in comparison with healthy controls (p=0.00). Significant differences in SF-36 were found between patients with chronic hepatitis C and B regarding physical functions, activity, physical pain and emotional functions. Multivariate linear regression analysis revealed ages below 50 years as the most important positive variable in chronic hepatitis C patients for total score of the quality of life and physical component score (B=14.5; SE=5.16; p=0.049; and B=16.4; SE=5.94; p=0.003, respectively). The most important positive variable for the mental component of the quality of life was male gender (B=15.3; SE=5.81; p=0.003). Conclusion. Quality of life is reduced in patients with chronic hepatitis C in comparison with healthy population. The quality of life in chronic hepatitis C patients is better than in patients with other non-viral chronic liver diseases. In comparison with patients with chronic hepatitis B, reduction in some domains of the quality of life is noted. Younger age is the most predictable group for the lowest damage of the total quality of life in patients with chronic hepatitis C patients among other socio- demographic characteristics of these patients.

scholarly journals Quality of Life of the Patients Suffering from Chronic Liver Diseases at the University Health Center Campus of Lome

2015 ◽  
Vol 05 (07) ◽  
pp. 88-93
Author(s):  
Aklesso Bagny ◽  
Oumboma Bouglouga ◽  
Late Mawuli Lawson-Ananissoh ◽  
Angelique Dusabe ◽  
Yeba Laconism Kaaga ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Center ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
The University
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