scholarly journals Measurement of Single-Breath Diffusing Capacity of the Lungs for Carbon Monoxide: new standards of European Respiratory Society and American Thoracic Society (рart 2)

2019 ◽  
Vol 29 (3) ◽  
pp. 269-291
Author(s):  
Article Editorial
Keyword(s):  
Carbon Monoxide ◽  
Expert Opinion ◽  
Transfer Factor ◽  
American Thoracic Society ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Single Breath ◽  
Published Evidence

This document is updated technical standards of European Respiratory Society (ERS) and American Thoracic Society (ATS) for single-breath carbon monoxide diffusing capacity measurement. The previous version of this document was published in 2005. Both terms used to describe the uptake of carbon monoxide in the lungs, DLCO (diffusing capacity) and TLCO (transfer factor), are equally valid, but the term DLCO is used in this document. The document was developed by joint ATS/ERS taskforce and was based on a survey of published evidence. Expert opinion was used for issues for which evidence was not available or was insufficient. Principal changes in the technical standards are related to new systems with rapidly responding gas analyzers for carbon monoxide. Additional materials are available at erj.ersjournals.com.Adopted from: Graham B.L., Brusasco V., Burgos F., Cooper B.G., Jensen R., Kendrick A., MacIntyre N.R., Thompson B.R., Wanger J. 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung. Eur. Respir. J. 2017; 49 (1): pii: 1600016. DOI: 10.1183/13993003.00016-2016.

scholarly journals Measurement of Single-Breath Diffusing Capacity of the Lungs for Carbon Monoxide: new standards of European Respiratory Society and American Thoracic Society (рart 1)

2019 ◽  
Vol 29 (2) ◽  
pp. 149-158
Author(s):  
Article Editorial
Keyword(s):  
Carbon Monoxide ◽  
Expert Opinion ◽  
Transfer Factor ◽  
American Thoracic Society ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Single Breath ◽  
Published Evidence

This document is updated technical standards of European Respiratory Society (ERS) and American Thoracic Society (ATS) for single-breath carbon monoxide diffusing capacity measurement. The previous version of this document was published in 2005. Both terms used to describe the uptake of carbon monoxide in the lungs, DLCO (diffusing capacity) and TLCO (transfer factor), are equally valid, but the term DLCO is used in this document. The document was developed by joint ATS/ERS taskforce and was based on a survey of published evidence. Expert opinion was used for issues for which evidence was not available or was insufficient. Principal changes in the technical standards are related to new systems with rapidly responding gas analyzers for carbon monoxide. Additional materials are available at erj.ersjournals.com.

scholarly journals 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

2017 ◽  
Vol 49 (1) ◽  
pp. 1600016 ◽  
Author(s):  
Brian L. Graham ◽  
Vito Brusasco ◽  
Felip Burgos ◽  
Brendan G. Cooper ◽  
Robert Jensen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Recent Literature ◽  
American Thoracic Society ◽  
Common Type ◽  
Diffusing Capacity ◽  
Tracer Gas ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Single Breath ◽  
The World

This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both DLCO (diffusing capacity) and TLCO (transfer factor) are valid terms to describe the uptake of carbon monoxide in the lung, the term DLCO is used in this document. A joint taskforce appointed by the ERS and ATS reviewed the recent literature on the measurement of DLCO and surveyed the current technical capabilities of instrumentation being manufactured around the world. The recommendations in this document represent the consensus of the taskforce members in regard to the evidence available for various aspects of DLCO measurement. Furthermore, it reflects the expert opinion of the taskforce members on areas in which peer-reviewed evidence was either not available or was incomplete. The major changes in these technical standards relate to DLCO measurement with systems using rapidly responding gas analysers for carbon monoxide and the tracer gas, which are now the most common type of DLCO instrumentation being manufactured. Technical improvements and the increased capability afforded by these new systems permit enhanced measurement of DLCO and the opportunity to include other optional measures of lung function.

scholarly journals Executive Summary: 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

2017 ◽  
Vol 49 (1) ◽  
pp. 16E0016 ◽  
Author(s):  
Brian L. Graham ◽  
Vito Brusasco ◽  
Felip Burgos ◽  
Brendan G. Cooper ◽  
Robert Jensen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
American Thoracic Society ◽  
Common Type ◽  
Tracer Gas ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Executive Summary ◽  
Link Type ◽  
Single Breath

This document summarises an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. The full standards are also available online as https://doi.org/10.1183/13993003.00016-2016. The major changes in these technical standards relate to DLCO measurement with systems using rapidly responding gas analysers for carbon monoxide and the tracer gas, which are now the most common type of DLCO instrumentation being manufactured. Technical improvements and the increased capability afforded by these new systems permit enhanced measurement of DLCO and the opportunity to include other optional measures of lung function.

The effect of conductive ventilation heterogeneity on diffusing capacity measurement

2008 ◽  
Vol 104 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Sylvia Verbanck ◽  
Daniel Schuermans ◽  
Sophie Van Malderen ◽  
Walter Vincken ◽  
Bruce Thompson
Keyword(s):  
Carbon Monoxide ◽  
Vital Capacity ◽  
Experimental Situation ◽  
Normal Subjects ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
Alveolar Volume ◽  
Estimation Errors ◽  
Single Breath ◽  
Ventilation Heterogeneity

It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and related the resulting changes in conductive ventilation heterogeneity (derived from the multiple-breath washout test) to corresponding changes in diffusing capacity, alveolar volume, and inspired vital capacity (derived from the single-breath DlCO method). Average conductive ventilation heterogeneity doubled ( P < 0.001), whereas DlCO decreased by 6% ( P < 0.001), with no correlation between individual data ( P > 0.1). Average inspired vital capacity and alveolar volume both decreased significantly by, respectively, 6 and 3%, and the individual changes in alveolar volume and in conductive ventilation heterogeneity were correlated ( r = −0.46; P = 0.006). These findings can be brought in agreement with recent modeling work, where specific ventilation heterogeneity resulting from different distributions of either inspired volume or end-expiratory lung volume have been shown to affect DlCO estimation errors in opposite ways. Even in the presence of flow asynchrony, these errors appear to largely cancel out in our experimental situation of histamine-induced conductive ventilation heterogeneity. Finally, we also predicted which alternative combination of specific ventilation heterogeneity and flow asynchrony could affect DlCO estimate in a more substantial fashion in diseased lungs, irrespective of any diffusion-dependent effects.

Single Breath Carbon Monoxide Diffusing Capacity (Transfer Factor): Reply

1988 ◽  
Vol 138 (4) ◽  
pp. 1084-1085 ◽  
Author(s):  
Robert O. Crapo ◽  
Reed M. Gardner ◽  
Steven L. Berlin
Keyword(s):  
Carbon Monoxide ◽  
Transfer Factor ◽  
Diffusing Capacity ◽  
Single Breath

scholarly journals New standards for measuring the diffusion capacity of the lungs by carbon monoxide by single breath method

2020 ◽  
pp. 15-23
Author(s):  
G. V. Nekludova ◽  
A. V. Chernyak
Keyword(s):  
Carbon Monoxide ◽  
Working Group ◽  
American Thoracic Society ◽  
Diagnostic Systems ◽  
European Respiratory Society ◽  
Diffusion Capacity ◽  
Single Breath ◽  
Joint Working Group ◽  
Single Breath Method

The article provides an overview of the technical capabilities and updated standards for the study of diffusion capacity of the lungs using diagnostic systems using rapidly responding gas analyzers (RGA analyzers — rapidly responding gas analyzers) of carbon monoxide and indicator gas, presented by a joint working group of the European Respiratory Society (ERC) and the American Thoracic Society (ATS).

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