scholarly journals Study of antinociceptive effect of paroxetine in acute pain in albino rats

2016 ◽  
pp. 1022-1028
Author(s):  
Yatish B. ◽  
Nadia Nausheen ◽  
Venkatesh Patil
Keyword(s):  
Acute Pain ◽  
Antinociceptive Effect ◽  
Albino Rats

scholarly journals A comparative study of antinociceptive effect of paroxetine with pethidine in acute pain in albino rats

2017 ◽  
Vol 6 (7) ◽  
pp. 1728
Author(s):  
Manju Gari ◽  
Kumari Ranjeeta ◽  
Lakhan Majhee ◽  
Akhilesh Kumar ◽  
Sumit Kumar Mahato
Keyword(s):  
Acute Pain ◽  
Water Immersion ◽  
Antinociceptive Effect ◽  
Warm Water ◽  
Albino Rats ◽  
Thermal Method ◽  
Average Weight ◽  
Tail Flick ◽  
Immersion Method ◽  
Standard Drug

Background: Pain is the most common reason patients seek medical care. Increased level of monoamines (serotonin and norepinephrine) in synaptic clefts lead to changes in pain threshold and induce antinociception. The study was carried out to evaluate antinociceptive effect of paroxetine in albino rats and to probe into its possible mechanism of action. The study was carried out to evaluate anti-nociceptive effect of paroxetine in albino rats.Methods: Male Albino rats of average weight 150-240gms were used. The drugs used were paroxetine 5mg/Kg, pethidine 5mg/kg (standard drug). Anti-nociceptive effect tested by using thermal method i.e. Tail flick response and Tail warm water immersion method.Results: In this study, Anti-nociceptive effect of respective drugs were measured by using two methods i.e. tail flick test and tail warm water immersion method at 0 min., 30 min., 60 min. and 90min.after administration of drugs. Reaction time started to increase from baseline at 0 min. and peak effect was seen at 60 min. then it started to decrease at 90 min. in almost all the groups except in control group.Conclusions: Paroxetine have significant analgesic effect in acute pain, which may be mediated via central and peripheral mechanisms. Efficacy of Paroxetine is almost equal to that of standard drug pethidine in acute pain management.

scholarly journals Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

2018 ◽  
Vol 68 (1) ◽  
pp. 108-118 ◽  
Author(s):  
Savić Vujović Katarina ◽  
Vučković Sonja ◽  
Stojanović Radan ◽  
Divac Nevena ◽  
Medić Branislava ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Acute Pain ◽  
Antinociceptive Effect ◽  
Nmda Antagonist ◽  
Anion Channel ◽  
Immersion Test ◽  
Nmda Receptor Antagonist ◽  
Albino Rats ◽  
Dependent Manner ◽  
Tail Immersion

Abstract Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that causes anion channel blockade in a dose-dependent manner. It has been established that ketamine and magnesium interact synergistically in the tail-immersion test in rats. To determine the role of serotonergic, GABAergic and noradrenergic systems in analgesia induced by the ketamine-magnesium sulfate combination. Experiments were performed on male Wistar albino rats (200-250 g). Antinociception was evaluated by the tail-immersion test. Methysergide (0.5 and 1 mg/kg, sc) administered alone did not affect nociception in rats. Methysergide (0.5 and 1 mg/kg, sc) antagonized the antinociceptive effect of the ketamine (5 mg/kg)-magnesium sulfate (5mg/kg) combination. Bicuculline (0.5 and 1 mg/kg, sc) given alone did not change the threshold to thermal stimuli in rats. Bicuculline (0.5 and 1 mg/kg, sc) antagonized the antinociceptive effect of the ketamine (5 mg/kg)-magnesium sulfate (5 mg/kg) combination. Yohimbine (0.5, 1 and 3 mg/kg, sc) applied alone did not change nociception. Yohimbine at a dose of 0.5 mg/kg did not influence the effect of ketamine (5 mg/kg)-magnesium sulfate (5 mg/kg), while yohimbine at doses of 1 and 3 mg/kg antagonized the antinociceptive effect of this combination. Serotonergic, noradrenergic and GABAergic systems participate, at least in part, in the antinociceptive effect of the ketamine-magnesium sulfate combination in acute pain in rats.

scholarly journals Antinociceptive evaluation of conventional anticonvulsant with conventional analgesics on pain model of albino rats and mice

2018 ◽  
Vol 6 (3) ◽  
pp. 790
Author(s):  
Ruchika Agarwal ◽  
Saurabh Kansal
Keyword(s):  
Chronic Pain ◽  
Acute Pain ◽  
Formalin Test ◽  
Visceral Pain ◽  
Diclofenac Sodium ◽  
Antinociceptive Effect ◽  
Albino Rats ◽  
Second Phase ◽  
Writhing Test ◽  
Rats And Mice

Background: Pain is one of the most common presentations of any disorder and needs immediate and appropriate attention of the treating physician. As pain syndrome involves a variety of etiopathogenesis and temporal domains, management of pain as such requires consideration of many factors that may dictate appropriate therapeutic management. Carabmazepine is an established drug for trigeminal neuralgia while Gabapentin has been tried in postoperative pain but its effectiveness per se and when compared to conventional analgesics needs to be evaluated.Methods: The present study was planned to study the analgesic effects of Gabapentin in various pain models like writhing and formalin test and to compare it with conventional analgesics like Diclofenac sodium and Tramadol in various acute pain models.Results: This study has been carried out in department of Pharmacology, HIMS, Dehradun, for evaluation of Gabapentin for its antinociceptive effect in rats and mice. In the writhing test, a reduction in number of writhes, though insignificant, was found in the Gabapentin pre-treatment group. However, in the first phase of Formalin test which is characterized by licking and biting, Gabapentin produced no significant effect in comparison to control values. In the second phase of leg raising (LR), all three drugs, i.e. Gabapentin and the two positive controls i.e. diclofenac and tramadol produced significant decrease (p< 0.05) in episodes when compared to the control group.Conclusions: Hence the result conclude that Gabapentin could be an effective analgesic drug in visceral and chronic pain in humans but not in acute pain as first phase of formalin test is model of acute and second phase denote chronic pain while writhing test is a model of visceral pain.

The Antinociceptive Effect of Intrathecal Administration of Glycine Transporter-2 Inhibitor ALX1393 in a Rat Acute Pain Model

2010 ◽  
Vol 110 (2) ◽  
pp. 615-621 ◽  
Author(s):  
Yasunori Haranishi ◽  
Koji Hara ◽  
Tadanori Terada ◽  
Seiya Nakamura ◽  
Takeyoshi Sata
Keyword(s):  
Acute Pain ◽  
Antinociceptive Effect ◽  
Intrathecal Administration ◽  
Pain Model ◽  
Glycine Transporter ◽  
Glycine Transporter 2

scholarly journals Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice

2013 ◽  
Vol 146 (1) ◽  
pp. 180-186 ◽  
Author(s):  
M.S. Brandão ◽  
S.S. Pereira ◽  
D.F. Lima ◽  
J.P.C. Oliveira ◽  
E.L.F. Ferreira ◽  
...  
Keyword(s):  
Acute Pain ◽  
Antinociceptive Effect

Ascending Nociceptive Control Contributes to the Antinociceptive Effect of Acupuncture in a Rat Model of Acute Pain

2014 ◽  
Vol 15 (4) ◽  
pp. 422-434 ◽  
Author(s):  
Glaucia Tobaldini ◽  
Betina Aisengart ◽  
Marcelo M.S. Lima ◽  
Claudia H. Tambeli ◽  
Luana Fischer
Keyword(s):  
Acute Pain ◽  
Rat Model ◽  
Antinociceptive Effect

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile 9 ]PK20 in an acute pain treatment in rodents

2016 ◽  
Vol 1648 ◽  
pp. 172-180 ◽  
Author(s):  
Patrycja Kleczkowska ◽  
Emmanuel Hermans ◽  
Piotr Kosson ◽  
Agnieszka Kowalczyk ◽  
Anna Lesniak ◽  
...  
Keyword(s):  
Acute Pain ◽  
Pain Treatment ◽  
Antinociceptive Effect ◽  
Hybrid Peptide

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

Life Sciences ◽  
2009 ◽  
Vol 84 (3-4) ◽  
pp. 105-110 ◽  
Author(s):  
L.S. Lopes ◽  
S.S. Pereira ◽  
L.L. Silva ◽  
K.A. Figueiredo ◽  
B.A. Moura ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Acute Pain ◽  
Antinociceptive Effect

Disinhibitory Involvement of the Anterior Cingulate Cortex in the Descending Antinociceptive Effect Induced by Electroacupuncture Stimulation in Rats

2008 ◽  
Vol 36 (03) ◽  
pp. 569-577 ◽  
Author(s):  
Takafumi Hirano ◽  
Jorge L. Zeredo ◽  
Mari Kimoto ◽  
Kentaro Moritaka ◽  
Fajar H. Nasution ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Antinociceptive Effect ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Albino Rats ◽  
Acupuncture Analgesia ◽  
Silver Plate ◽  
Antidromic Activation ◽  
Acupuncture Stimulation ◽  
Tungsten Microelectrode

The present study was conducted to clarify the role of the anterior cingulate cortex (ACCX) in acupuncture analgesia. Experiments were performed on 35 female Wistar albino rats weighing about 300 g. Single unit recordings were made from ACCX neurons with a tungsten microelectrode. Descending ACCX neurons were identified by antidromic activation from electrical shocks applied to the ventral part of the ipsilateral PAG through a concentric needle electrode. Cathodal electroacupuncture stimulation of Ho-Ku (0.1 ms in duration, 45 Hz) for 15 min was done by inserting stainless steel needles bilaterally. An anodal silver-plate electrode (30 mm × 30 mm ) was placed on the center of the abdomen. Naloxone (1.0 mg/kg, i.v.) was used to test whether changes of ACCX activities were induced by the endogenous opioid system. Data were collected from a total of 73 ACCX neurons. Forty-seven neurons had descending projection to the PAG, and the other 26 had no projections to the PAG. A majority of descending ACCX neurons were inhibited by electroacupuncture stimulation. By contrast, non-projection ACCX neurons were mainly unaffected by electroacupuncture. Naloxone did not reverse acupuncture effects on the changes of ACCX neuronal activities. Acupuncture stimulation had predominantly inhibitory effects on the activities of descending ACCX neurons. Since the functional connection between ACCX and PAG is inhibitory, electroacupuncture caused disinhibition of PAG neurons, whose activity is closely related to descending antinociception to the spinal cord. This disinhibitory effect elicited by acupuncture stimulation is thought to play a significant role in acupuncture analgesia.

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