Role of sex hormone binding globulin as the early predictor for gestational diabetes mellitus

Background: The aim of this study was to find role of SHBG as an early predictor for gestational diabetes mellitus.Methods: A hospital based prospective/observational/diagnostic and explorative study. The necessary information was collected from the participants through the prepared set of questionnaires. Pregnant women between 11 to 14 weeks of gestation who visited JSS OPD for antenatal checkup satisfying inclusion and exclusion criteria giving informed and written consent for the study were examined clinically. 3ml of venous blood was drawn with aseptic precautions for the estimation of SHBG and adiponectin. OGTT with 75gms glucose first done at 11 to 14weeks and again at 24-28 weeks and 32-36 weeks were done to the same patient to find out whether the patient developed GDM or not. These mothers were followed periodically till delivery. The sensitivity and specificity of SHBG were assessed and compared in patients who developed GDM.Results: 100 cases were selected for the study. About 12 patients were diagnosed as gestational diabetes mellitus in present study by OGCT at 32 weeks to 36 weeks. In present study about 14 patients had low level of SHBG. Low level of SHBG is found to be statistically significant in predicting GDM in first trimester.Conclusions: The combination of SHBG can be used as predictor of GDM in first trimester.

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Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.12525 ◽

2014 ◽

Vol 41 (2) ◽

pp. 193-198 ◽

Cited By ~ 8

Author(s):

Yavuz M. Gözükara ◽

Hakan Aytan ◽

Devrim Ertunc ◽

Ekrem C. Tok ◽

Fazli Demirtürk ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

Total Testosterone

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Role of mean platelet volume in pregnancy to predict gestational diabetes mellitus in the first trimester

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2019.1583730 ◽

2019 ◽

Vol 33 (21) ◽

pp. 3689-3694 ◽

Cited By ~ 3

Author(s):

Eser Colak ◽

Emel Ebru Ozcimen ◽

Mehmet Ufuk Ceran ◽

Yusuf Aytac Tohma ◽

Sevsen Kulaksızoglu

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Mean Platelet Volume ◽

First Trimester ◽

Platelet Volume ◽

In Pregnancy

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Is first trimester measurement of sex hormone binding globulin a possible screening test for gestational diabetes mellitus?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2004.01.085 ◽

2004 ◽

Vol 190 (6) ◽

pp. 1808-1809 ◽

Cited By ~ 2

Author(s):

Monica R McClain ◽

Glenn E Palomaki ◽

James E Haddow

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Screening Test ◽

First Trimester ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Hormone Binding

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Role of pregravid diet and metformin in the prophylaxis of gestational diabetes and its complications

Journal of obstetrics and women s diseases ◽

10.17816/jowd67413-18 ◽

2018 ◽

Vol 67 (4) ◽

pp. 13-18

Author(s):

Evgeny K Komarov ◽

Tamara A Pluzhnicova ◽

Elena V Nicologorskaya ◽

Ekaterina A Alabieva

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Venous Blood ◽

Diet Therapy ◽

Significant Loss ◽

Oral Glucose ◽

Normal Body Mass Index ◽

Glucose Load

The aim of this study was to improve the method for diagnosing insulin resistance (IR) and to assess the effect of pregravid diet alone or dietary supplementation in combination with metformin on the development of gestational diabetes mellitus (GDM) and its complications in patients with pre-diabetes. At the first stage of the study, glucose level was determined in the capillary blood of 61 women and, in the second stage, in the venous blood plasma of 60 individuals. The 75 g oral glucose tolerance test was performed in all patients. Plasma insulin level and IR index were determined basal (HOMA-IR) and two hours after the glucose load. The presence of IR was found in 68 women. All of them were treated with a diet, with 34 patients additionally treated with metformin at a dose of 1500 mg per day. The duration of therapy was 3-6 months.It has been shown that the evaluation of IR index two hours after the glucose load significantly (p < 0.05) increases the diagnosis of the IR status, as in 56.5% of women with IR, the fasting IR (HOMA-IR) values were normal. The use of metformin combined with diet therapy in patients with IR, with easily assimilated carbohydrates excluded at the pregravid stage, is accompanied by a more significant loss of body weight with the achievement of a normal body mass index for pregnancy, when compared to diet therapy alone. In patients with IR after pregravid treatment with diet or diet with metformin, the frequency of obstetric complications, as well as of gestational diabetes mellitus, is comparable with that in normal women. In addition, such pregravid treatment protects patiens with IR from superfluous weight gain and fetal macrosomia. (For citation: Komarov ЕК, Pluzhnikova ТА, Nikologorskaya ЕV, Alyabyeva ЕА. Role of pregravid diet and metformin in the prophylaxis of gestational diabetes and its complications. Journal of Obstetrics and Women’s Diseases. 2018;67(4):13-18. doi: 10.17816/JOWD67413-18).

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