scholarly journals Efficacy of fine needle aspiration cytology in the diagnosis of lymphadenopathies

2017 ◽  
Vol 5 (4) ◽  
pp. 1607
Author(s):  
Rasheed Fatima ◽  
Sandhya M.
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Cost Effective ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Histopathological Diagnosis ◽  
Fine Needle

Background: Enlarged lymph nodes were the first organs to be diagnosed by fine needle aspiration. Objectives were to study the role of FNAC in the evaluation of lymphadenopathies, to study the various cyto-morphological patterns in correlation with histopathology of various lymph node lesions and to document the diagnostic accuracy of FNAC in correlation with histopathology.Methods: All patients referred to the department of pathology K.V.G. Medical College and Hospital, Sullia, Karnataka, India for FNAC of palpable lymph nodes were included in present study. FNAC was done and the standard method for the procedure adopted. All the slides were reviewed and their diagnosis was made. FNAC diagnosis was compared with histopathology in cases which underwent surgical excision and thus its diagnostic accuracy determined. This was two years and two months’ prospective study from July 2008 to August 2010.Results: A total of` 150 patients were included in the present study, reported to various clinical departments with history of swelling. Lymph node biopsy was done in 50 cases. Statistical analysis was done in 50 cases, where FNAC diagnosis was correlated well with histopathological diagnosis. Maximum number of cases was in the age group of 31-40 years. Present study showed female preponderance of cases. Cervical group of nodes were most commonly involved. Benign lymphadenopathies were diagnosed in 69.8% of cases. Maximum number of cases being reactive lymphadenitis (65.4%). Metastatic deposit was diagnosed in 23.5% of cases. Most common subtype being adenocarcinoma. Lymphomas were diagnosed in 09 cases. 1 case of Hodgkin’s lymphoma and 8 cases of NHL were diagnosed. The overall correlation between FNAC and histopathology was 98% (49 out of 50).Conclusions: FNAC is an accurate, sensitive, specific and cost effective procedure in the diagnosis of lymphadenopathies.

scholarly journals Distribution of Various Malignant Lesions in Lymph Node Cytology – A 1 Year Population Based Study from a Tertiary Care Centre in North-East India

2021 ◽  
Vol 8 (17) ◽  
pp. 1090-1094
Author(s):  
Badrinath Venkatesh ◽  
Khagokpam Ambala Devi ◽  
Soram Gayatri Gatphoh
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Tertiary Care ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
Metastatic Tumour ◽  
Fine Needle ◽  
North East ◽  
Malignant Lesions

BACKGROUND Lymph nodes (LN) are an integral component of the immune system. Enlarged lymph nodes are a prime target for fine needle aspiration (FNA). Lymph nodes greater than 1 to 2 cm are an immediate source of concern. Lymphadenopathy is a common presenting symptom in various diseases. Fine needle aspiration cytology (FNAC) confirms the presence of metastatic disease and gives a clue regarding its nature and origin of primary malignancy. In many metastatic malignancies, FNAC may be the only tool for diagnosis and further management of the patients. We intend to assess the cytomorphological patterns of both primary tumour and metastatic tumour in a lymph node. METHODS A retrospective study was conducted in the Department of Pathology, RIMS, Imphal, over a period of one year from January 1, 2018 to December 31, 2018. Five hundred and fifty-five lymph nodes were aspirated, out of which 99 cases turned out to be malignant lesions. Giemsa and PAP stained FNAC slides were collected and reviewed. Data entry and analysis were done by using SPSS version 21. RESULTS Out of 99 cases, 88.9 % were metastatic tumours and 11.1 % were of primary lymphoproliferative disorders. Thirty three percent of malignant lymphadenopathy were found in fifth decade. Undifferentiated carcinoma constituted around 32.3 % of all the cases of malignant lymphadenopathy. Cervical group of lymph nodes were involved in 46.5 % of cases. CONCLUSIONS FNAC has proved to be a useful tool in diagnosing malignancy with good certainty. FNAC of lymph nodes prevents complications associated with lymph node biopsy. KEYWORDS FNAC, Lymph Node, Undifferentiated Carcinoma, Squamous Cell Carcinoma

scholarly journals CYFRA 21-1 in Lymph Node Fine Needle Aspiration Washout Improves Diagnostic Accuracy for Metastatic Lymph Nodes of Differentiated Thyroid Cancer

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 487 ◽  
Author(s):  
Jeongmin Lee ◽  
Hye Lim Park ◽  
Chan-Wook Jeong ◽  
Jeonghoon Ha ◽  
Kwanhoon Jo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Metastatic Lymph Node ◽  
Needle Aspiration ◽  
Diagnostic Modality ◽  
Fine Needle ◽  
Metastatic Lymph ◽  
Diagnostic Values

Fine needle aspiration cytology (FNAC) and washout thyroglobulin (Tg) measurements are the standard for evaluating a metastatic lymph node (LN) in thyroid cancer. However, patients rarely benefit from these procedures due to false results. This study aims to identify a reliable biomarker that significantly improves the diagnosis of metastatic LNs, in addition to FNAC and washout Tg. This study analyzed 130 LNs that were suspected to have metastases on thyroid ultrasonography, from June 2016 to December 2017. All subjects underwent FNAC, washout Tg measurements and a new biomarker, washout Cytokeratin fragment 21-1 (CYFRA 21-1) measurement. The final LN outcomes were confirmed by surgical histology, repeat FNAC, or follow-up image. The diagnostic values of the presence of washout CYFRA 21-1 for diagnosing metastatic LNs were evaluated according to final LN outcomes. Among the 130 LNs, 42 were metastatic lesions and 88 were benign. The washout CYFRA 21-1 levels were significantly higher in metastatic LNs than in benign LNs. In contrast to the findings of washout Tg, washout CYFRA 21-1 showed little overlap between benign and malignant LNs, and its diagnostic cutoff values were not affected by surgery. The combinations of FNAC and washout CYFRA 21-1 showed higher sensitivity (91.9%), specificity (96.5%), negative predictive value (98.8%), and diagnostic accuracy (94.2%) than FNAC with washout Tg. The combination of FNAC, washout Tg, and washout CYFRA 21-1 showed the best sensitivity (98.8%). When washout CYFRA 21-1 was applied to the discordant results that were observed between FNAC and washout Tg, 20 of 22 LNs were correctly diagnosed. Washout CYFRA 21-1 measurements in thyroid LNs provide a diagnostic modality.

scholarly journals Clinicopathological Correlation in Patients of Lymphadenopathy in Tertiary Care Hospital

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Dr. Amol R. Rajhans, MD ◽  
Dr. Deepak S. Howale
Keyword(s):  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Cost Effective ◽  
Clinical Problem ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Lymph nodes are parts of the lymphatic system. Lymph node helps to filter out viruses, bacteria, cancer cells and other unwanted substances safely removed from the body. Lymphadenopathy is common clinical problem frequently give dilemma in diagnostic. Enlargement of lymph node is a common problem which evaluate as a Lymphadenopathy. An abnormality in size and character of lymph node in known as Lymphadenopathy which also consider as enlarged abnormally that measures more than 10mm in its diameter than normal. Lymphadenopathy is common clinical problem frequently give dilemma in diagnostic. Fine needle aspiration cytology (FNAC) has become an important tool for initial diagnosis and management for patients suffering from Lymphadenopathy because of early result, simple for test and minimal trauma to patient. The main aim of this study is to Correlation of Clinicopathological condition presenting with Lymphadenopathy. Role of FNAC in diagnosis will also evaluate with node biopsy and open lymph. Material and methods: Total 100 patients were included in this study. For all 100 patients fine needle aspiration cytology (FNAC) was done. In 75 cases excision biopsy was done. Pathological diagnosis was obtained in all cases. Fine needle aspiration cytology, excision biopsy, throat, ear and nose examination were carried out as a required base line investigations. Result: Total 80 patients were studies in this study. Out of this 80 patients 30 cases were IPD and remaining were OPD. FNAC as well as biopsy were carried out from total patients in this study. In this study Tubercular Lymphadenitis was observer maximum. Out of 80 patients 47(58.75%) were male and 33(41.25%) were female patients. Age group 20-30 years (35%) were maximum number of patients which was followed by 30-40 years (23.75%) and 10-20 years (21.25%) respectively was observed. Out of 80 patients 50(62.5%) were diagnosis as Tubercular Lymphadenitis and Chronic Non-specific Lymphadenitis was diagnosis in 10 (12.5%). Reactive lymphadenitis was diagnosed in 8(10%) patients whereas Malignant secondary’s were diagnosed in 7(8.75%) patients followed by 3(3.75%) patients suffer from lymphomas and 2(2.5%) were Non- Hodgkin's Lymphoma. Conclusion: Lymphadenopathy is a clinical evaluation followed by FNAC which is reliable diagnostic tool that is easy to perform; cost effective, speedy results accurate can be obtained. Specialist input is the main requirement for this. Biopsy is also useful in cases of lymphomas that act as diagnostic tool. When FNAC report is inconclusive, in nonspecific lymphadenitis than Biopsy is much helpful for accurate diagnosis and management. Hence, in cases of Lymphadenopathy FNAC was found to be reliable, simple and cost effective method for diagnosis.

scholarly journals Study of diagnostic accuracy of fine needle aspiration cytology of lymph nodes over 6 years in a tertiary care hospital

2017 ◽  
Vol 5 (9) ◽  
pp. 4013
Author(s):  
Sanghita Barui ◽  
Prosenjit Ganguli ◽  
Parikshit Sanyal ◽  
Niloy Pathak
Keyword(s):  
Lymph Node ◽  
Diagnostic Accuracy ◽  
Metastatic Disease ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Granulomatous Disease ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Lymph node fine needle aspiration cytology (FNAC) is the first line investigation for evaluation of lymph node disease. Existing literature reports high degree of correlation between lymph node FNAC and histological examination. The aim of the present study is to re-evaluate the diagnostic accuracy of FNAC in view of frequent discordance between FNAC and diagnosis on biopsy.Methods: Among a total of 495 lymph node FNACs and 291 biopsies, 69 adequate FNACs which were followed up with biopsy were evaluated with standard statistical methods for assessment of diagnostic accuracy.Results: The commonest diagnosis on biopsy was reactive lymph node (34.71%) followed by granulomatous disease (26.12%) and lymphoid neoplasms (20.96%). Reactive lymphadenitis and granulomatous disease were also the two commonest categories on FNAC (34.34% and 24.85% respectively). However, the sensitivity of FNAC in diagnosis of granulomatous disease was found to be 45.83%, which increases to 70.03% if necrosis is included as a marker of granulomatous disease. The greatest sensitivity was achieved in diagnosis of metastatic disease (88.89%), followed by lymphoid neoplasms (69.23%).Conclusions: FNAC is a useful tool for excluding specific categories of lymph node diseases, esp. metastatic disease. However, the technique needs improvement as to sample more representative areas of the node, to improve its sensitivity.

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