scholarly journals Open-angle glaucoma in diabetic patients’ prevalence and risk factors: a cross-sectional study in Sudan

Author(s):  
Omyma Abbas Banaga Salih ◽  
Ehab Hamed

Background: Diabetic patients are at increased risk of glaucoma compared to the general population. Risk factors for glaucoma that is specific to diabetic patients include increased IOP, retinopathy and neovascular changes and years since diagnosis of diabetes. This cross-sectional study aims to report on the prevalence of glaucoma in diabetic patients in community diabetes centre in Sudan and examine associations with previously reported risk factors.Methods: A cross-sectional study was carried out in Omdurman specialised diabetic healthcare centre in Sudan. A total of 300 patients consented to participation. All patients filled in a survey for both demographics and diabetic disease history then had an assessment for glaucoma by an ophthalmologist. The assessment included examination of the anterior segment, optic nerve assessment and fundus examination using a stereoscopic slit lamp, intraocular pressure (IOP) measurement using tonometry, peripheral anterior chamber configuration and depth assessments using gonioscopy and central visual field assessment using perimetry.Results: Prevalence of open-angle glaucoma diagnosis was 2.8% among diabetic patients who were included in this study. Family history for glaucoma was significantly associated with increased risk of open-angle glaucoma (OR 5.67, 95% CI 1.74-18.45). Retinopathy was also associated with an increased risk of developing the condition (OR 3.1, 95% CI 1.11-8.51). Gender, years since diabetes diagnosis and medications did not have significant associations.Conclusions: Patients with diabetes are at increased risk of developing open-angle glaucoma, but the prevalence among the diabetic population attending community diabetes centre in Sudan remains low. Among different clinical determinants, diabetic retinopathy and genetic determinants may explain the increased risk in the diabetic population.

2018 ◽  
Vol 22 (5) ◽  
pp. 376-382 ◽  
Author(s):  
Henrique de Alencar Gomes ◽  
Bruno de Souza Moreira ◽  
Rosana Ferreira Sampaio ◽  
Sheyla Rossana Cavalcanti Furtado ◽  
Sebastião Cronemberger ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168682 ◽  
Author(s):  
Gyu Ah Kim ◽  
Se Hee Park ◽  
Jaesang Ko ◽  
Si Hyung Lee ◽  
Hyoung Won Bae ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0164983 ◽  
Author(s):  
Si Hyung Lee ◽  
Eun Min Kang ◽  
Gyu Ah Kim ◽  
Seung Woo Kwak ◽  
Joon Mo Kim ◽  
...  

Author(s):  
Raheeba Pakeer Muhammed ◽  
Neeta Sidhan ◽  
Beena Thankappan

Introduction: Various haemodynamic factors have been implicated as pathophysiological mechanisms in Primary Open Angle Glaucoma (POAG) other than raised Intraocular Pressure (IOP). However, the exact relationship still remains unclear. Aim: To examine the circadian pattern of Blood Pressure (BP), IOP and Ocular Perfusion Pressure (OPP) with the aim of understanding their relationships in a cohort of patients with POAG. Materials and Methods: A cross-sectional study was conducted in which 44 cases of newly diagnosed, non-hypertensive patients with POAG were enrolled and categorised based on the severity of glaucoma. Recording of BP and IOP were done every 4th hourly during a 24 hour hospital stay. The Mean OPP (MOPP) was calculated as 2/3×Mean Arterial Pressure (MAP)-IOP. Systolic OPP (SOPP) was calculated as Systolic BP-IOP and Diastolic OPP (DOPP) was calculated as Diastolic BP-IOP. The diurnal, nocturnal and 24 hour fluctuations were derived from the difference between the highest and lowest values within each period. Data was analysed using Statistical Package for the Social Sciences (SPSS) version 16.0. Univariate and multivariate regression analysis of the variables with age and severity of POAG were performed Results: Significant positive correlation of the nocturnal fluctuations in MAP (r=0.533), SOPP (r=0.835), DOPP (r =0.768), MOPP (r=0.685) and 24 hour fluctuation in MOPP (r=0.636) were noted with severity of glaucoma on multivariate analysis. No significant correlation of these parameters with age was noted on multivariate analyses. Conclusion: Nocturnal dip in OPP was an important observation among patients with POAG, potentially contributing to its pathophysiology.


2018 ◽  
Vol 7 (01) ◽  
pp. 47-49
Author(s):  
Pandiyaraj Saravanasankar ◽  
Anbazhaghan Amudha ◽  
Srinivasan Muralikrishnan ◽  
Reethysreekumar Sruthi ◽  
Rajan Saranya ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0204955 ◽  
Author(s):  
Reiko Kinouchi ◽  
Satoshi Ishiko ◽  
Kazuomi Hanada ◽  
Hiroki Hayashi ◽  
Daiki Mikami ◽  
...  

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