scholarly journals Multiple cystic lesions in the abdominopelvic cavity one and a half years after resection of presacral neurogenic tumor: tumor recurrence or other?

2020 ◽  
Vol 7 (12) ◽  
pp. 4180
Author(s):  
Umar Zeb Khan ◽  
Matiullah Masroor ◽  
Hai Liu
Keyword(s):  
Spontaneous Rupture ◽  
Tumor Recurrence ◽  
Tumor Resection ◽  
Abdominal Distension ◽  
Neurogenic Tumor ◽  
Ct Scans ◽  
Cystic Degeneration ◽  
Cystic Lesions ◽  
Local Hospital ◽  
Neurogenic Tumors

Cystic lesions of abdominopelvic cavity include a variety of pathologies and diagnosis can sometimes be challenging. Urinoma can be caused by iatrogenic injury, spontaneous rupture of ureters or by various causes of ureteral obstruction. It needs to be differentiated from abdominopelvic cystic diseases including tumors that can undergo cystic degeneration. Here we report a case of a 41 years old female underwent a presacral neurogenic tumor resection at a local hospital 5 years ago. The tumor recurred three and a half years after the first surgery and removed at another hospital. She experienced abdominal distension and difficulty in urination from the last 2 months and was diagnosed as having a recurrence of tumor once again at both hospitals on separate CT scans. They believed that the tumor was too large and encroaching on adjacent organs to be surgically resected, she was finally diagnosed as infected urinoma during surgery in our hospital. Even though spontaneous rupture of ureters and urinoma formation is a rare disease but it should be considered as a main differential diagnosis of recurrence of neurogenic tumors especially in post abdominopelvic surgeries patient.

scholarly journals Rare Case of Adult Undifferentiated (Embryonal) Sarcoma of the Liver Treated with Liver Transplantation: Excellent Long-Term Survival

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Renumathy Dhanasekaran ◽  
Alan Hemming ◽  
Elaine Salazar ◽  
Roniel Cabrera
Keyword(s):  
Liver Transplantation ◽  
Tumor Recurrence ◽  
Rare Case ◽  
Abdominal Distension ◽  
Ct Scans ◽  
Left Hepatic Lobe ◽  
Term Survival ◽  
Cell Sarcoma ◽  
Embryonal Sarcoma

We present the case of a 54-year-old gentleman who presented with abdominal distension and a CT scan of his abdomen revealed a large (25 cm) left hepatic lobe tumor. He received chemotherapy for over 1.5 years. The CT scans at the completion of this therapy revealed that the tumor had actually slightly grown in size. He underwent orthotopic liver transplantation without any major complications. The explant histopathology revealed an undifferentiated embryonal cell sarcoma (UECS) composed of relatively bland spindled cells arranged in short fascicles. It is now 10 years and 3 months since his last transplant and the patient remains well with no tumor recurrence.

Cysts in malignant gliomas

1980 ◽  
Vol 53 (6) ◽  
pp. 821-825 ◽  
Author(s):  
Denes Afra ◽  
David Norman ◽  
Victor A. Levin
Keyword(s):  
Tumor Recurrence ◽  
Diagnostic Procedure ◽  
Clinical Course ◽  
Malignant Gliomas ◽  
Needle Aspiration ◽  
Ct Scans ◽  
Cystic Lesions ◽  
Content Type ◽  
Necrotic Tumor ◽  
Repeated Aspiration

✓ The clinical course, computerized tomography (CT) scans, and postmortem reports for 265 patients treated for malignant brain tumors were reviewed. Forty-one patients underwent reoperation for tumor recurrence and one had needle aspiration as a diagnostic procedure; of these patients, seven (3% of 265 and 17% of 42) were diagnosed as harboring tumor cysts and 10 (25% of 41) as having necrotic tumor centers. The CT scans on the 17 patients harboring tumors with surgically confirmed cysts and necrotic centers were reviewed; criteria for distinguishing between cysts and central necrosis are suggested. The relative benefits of repeated aspiration and surgical therapy for these cystic lesions are discussed.

SPECIFIC CHARACTERISTICS OF BONE STRUCTURES ON CT-SCANS OF PATIENTS WITH SINONASAL INVERTED PAPILLOMAS

2019 ◽  
Vol 65 (4) ◽  
pp. 590-595
Author(s):  
Arkadiy Naumenko ◽  
Kseniya Sapova ◽  
Oleg Konoplev ◽  
Svetlana Astashchenko ◽  
Igor Chernushevich
Keyword(s):  
Computed Tomography ◽  
Tumor Recurrence ◽  
Inverted Papilloma ◽  
Ct Scans ◽  
Precise Localization ◽  
Sinonasal Inverted Papilloma ◽  
Bone Structures ◽  
Inverted Papillomas

Precise localization and excision of the originating site of a sinonasal inverted papilloma is essential for decreasing tumor recurrence. In this study we evaluated the use of preoperative computed tomography (CT) to pinpoint the attachment/origi-nating sites of the tumor.

scholarly journals A solitary giant neurofibroma of inguinal region: A case report

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042110042
Author(s):  
Haiying Zhou ◽  
Hui Lu
Keyword(s):  
Tumor Resection ◽  
Clinical Manifestations ◽  
Inguinal Region ◽  
Nerve Sheath Tumor ◽  
Neurogenic Tumors ◽  
Long Time ◽  
Giant Neurofibroma ◽  
History Of ◽  
Neuroectodermal Origin ◽  
Recurrence Tendency

Neurofibroma is a rare nerve sheath tumor of neuroectodermal origin, especially the huge and isolated neurofibroma located in the inguinal region. To our knowledge, no such case has previously been reported. We report a case of 34-year-old male patient with a 4-year history of progressive enlargement of the medial root mass in his left thigh with sitting and standing disorders along with pain. The tumor was completely removed by operation, and pathological diagnosis showed neurofibroma. There was no obvious neurologic defect after surgery, and no recurrence tendency was found in the follow-up of 2 years. For a large solitary mass with slow growth and no malignant clinical manifestations for a long time, clinicians cannot rule out the hypothetical diagnosis of neurofibroma, even though its growth site is very rare, such as this case of a huge tumor located in the groin. For neurogenic tumors, early operation should be performed, and the prognosis of patients after tumor resection is excellent.

scholarly journals Levels of Circulating PD-L1 Are Decreased in Patients with Resectable Cholangiocarcinoma

2021 ◽  
Vol 22 (12) ◽  
pp. 6569
Author(s):  
Christoph Roderburg ◽  
Sven H. Loosen ◽  
Jan Bednarsch ◽  
Patrick H. Alizai ◽  
Anjali A. Roeth ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Tumor Biology ◽  
Tumor Resection ◽  
Postoperative Outcome ◽  
Serum Levels ◽  
Strong Trend ◽  
Programmed Cell Death 1 ◽  
Early Tumor ◽  
Circulating Levels

Tumor resection represents the only curative treatment option for patients with biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (CCA), perihilar and extrahepatic CCA and gallbladder cancer. However, many patients develop early tumor recurrence and are unlikely to benefit from surgery. Therefore, markers to identify ideal surgical candidates are urgently needed. Circulating programmed cell death 1 ligand 1 (PD-L1) has recently been associated with different malignancies, including pancreatic cancer which closely resembles BTC in terms of patients’ prognosis and tumor biology. Here, we aim at evaluating a potential role of circulating PD-L1 as a novel biomarker for resectable BTC. Methods: Serum levels of PD-L1 were analyzed by ELISA in 73 BTC patients and 42 healthy controls. Results: Circulating levels of preoperative PD-L1 were significantly lower in patients with BTC compared to controls. Patients with low PD-L1 levels displayed a strong trend towards an impaired prognosis, and circulating PD-L1 was negatively correlated with experimental markers of promalignant tumor characteristics such as CCL1, CCL21, CCL25 and CCL26. For 37 out of 73 patients, postoperative PD-L1 levels were available. Interestingly, after tumor resection, circulating PD-L1 raised to almost normal levels. Notably, patients with further decreasing PD-L1 concentrations after surgery showed a trend towards an impaired postoperative outcome. Conclusion: Circulating PD-L1 levels were decreased in patients with resectable BTC. Lack of normalization of PD-L1 levels after surgery might identify patients at high risk for tumor recurrence or adverse outcome.

MANAGEMENT OF INTRATHORACIC NERVE TUMORS IN YOUNG CHILDREN

PEDIATRICS ◽  
1949 ◽  
Vol 4 (3) ◽  
pp. 342-348
Author(s):  
JOHN C. JONES ◽  
DONALD B. EFFLER
Keyword(s):  
Young Children ◽  
Operative Management ◽  
Posterior Mediastinum ◽  
Neurogenic Tumor ◽  
Review Of The Literature ◽  
Case Histories ◽  
Neurogenic Tumors ◽  
Degree Of Certainty ◽  
Malignant Changes

A brief review of the literature referring to intrathoracic nerve tumors in children is presented. The neurogenic tumors have an expected incidence of malignancy of about 40%. Four case histories are reported in which neurogenic tumors of the posterior mediastinum were removed with apparent cure. Only one of these children had objective or subjective signs which could be attributed to their neoplasms. All of the neoplasms were benign. Prompt thoracotomy is advocated in the child with a suspected neurogenic tumor of the mediastinum. Periods of observation, procrastination and roentgen therapy are to be condemned for it is impossible to predict with any degree of certainty which tumor will or already has undergone malignant changes. A brief discussion of the operative management and complications is presented.

Iodine-125 interstitial brachytherapy after tumor excision: an alternative eye-sparing surgery for lacrimal gland carcinoma

2021 ◽  
Author(s):  
Yang-jun Li ◽  
Ping Wang ◽  
Shao-bo Zhang ◽  
Xiao-na Ning ◽  
Chen-jun Guo ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Tumor Recurrence ◽  
Tumor Resection ◽  
Interstitial Brachytherapy ◽  
Tumor Excision ◽  
Control Tumor ◽  
Gland Carcinoma ◽  
Iodine 125 ◽  
Good Cosmesis

Abstract Background:To describe the preliminary suppressive effects of iodine 125 brachytherapy for malignant lacrimal gland tumors after excisionMethods:The study recruit 9 patients with lacrimal gland carcinoma from May 2017 to December 2020. All patients underwent eye sparing surgical tumor resection first and then received iodine 125 interstitial brachytherapy to prevent tumor recurrence. We look over whether tumor recurred or metastasized by detecting the visual function and CT/MRI/PET MRI of every patient.Results1 patient was lost visit. The median follow up period was 29 months of other 8 patients (range, 7 43 months). One patient experienced recurrence two years later but was free from local disease after iodine 125 seeds were implanted one more time. The vision of one female patient was lost due to the seeds moving to the optic nerve. In the remaining 6 patients the vision was no changed, and CT/MRI showed no tumor was recurrencedConclusions:Permanent iodine 125 strip implantation in the orbit can be used as an alternative eye sparing surgery for malignant lacrimal gland tumors after tumor excision. It can control tumor recurrence and maintenance of vision and good cosmesis.

Spontaneous Rupture of the Left Subclavian Artery in Neurofibromatosis

2003 ◽  
Vol 11 (3) ◽  
pp. 266-268 ◽  
Author(s):  
Worawong Slisatkorn ◽  
Thaworn Subtaweesin ◽  
Pansak Laksanabunsong ◽  
Malee Warnnissorn
Keyword(s):  
Computed Tomography ◽  
Subclavian Artery ◽  
Spontaneous Rupture ◽  
Left Subclavian Artery ◽  
Ct Scans

Two patients with neurofibromatosis presented with expanding masses at the left supraclavicular region. Computed tomography (CT) scans revealed vascular masses. The patients underwent surgery and ruptures of the left subclavian artery were found. Both patients were treated by ligation of subclavian artery.

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

2013 ◽  
Vol 119 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Ibrahim Hussain ◽  
Jean Anderson Eloy ◽  
Peter W. Carmel ◽  
James K. Liu
Keyword(s):  
Tumor Recurrence ◽  
Genetic Basis ◽  
Tumor Resection ◽  
Genetically Engineered ◽  
Subtotal Resection ◽  
Intracranial Tumors ◽  
Optimal Response ◽  
Genomic Technologies ◽  
Molecular Studies ◽  
Generation Sequencing

Craniopharyngiomas are benign intracranial tumors that arise in the suprasellar and intrasellar region in children and adults. They are associated with calcification on neuroimaging, endocrinopathies, vision problems, and recurrence following subtotal resection. Molecular studies into their genetic basis have been limited, and therefore targeted medical therapies for this tumor have eluded physicians. With the discovery of aberrant Wnt/β-catenin pathway signaling in the pathogenesis of the most common subtype of craniopharyngioma (adamantinomatous), the identification of candidate genes and proteins implicated in this cascade provide attractive targets for future therapies. The recent development of a genetically engineered animal model of this tumor may also serve as a platform for evaluating potential therapies prior to clinical trials in humans. Advances in understanding the molecular pathogenesis of tumor recurrence have also been made, providing clues to develop adjuvant and neoadjuvant therapies to couple with tumor resection for optimal response rates. Finally, advances in genomic technologies and next-generation sequencing will underlie the translation of these genetic and molecular studies from the bench to clinical practice. In this review, the authors present an analysis of the molecular oncogenesis of craniopharyngioma and current directions in the development of novel therapies for these morbid, yet poorly understood brain tumors.

Intraoperative electrocorticography during tumor resection: impact on seizure outcome in patients with gangliogliomas

1993 ◽  
Vol 78 (6) ◽  
pp. 891-902 ◽  
Author(s):  
Webster H. Pilcher ◽  
Daniel L. Silbergeld ◽  
Mitchel S. Berger ◽  
George A. Ojemann
Keyword(s):  
Tumor Recurrence ◽  
Tumor Resection ◽  
Neurological Deficits ◽  
Seizure Outcome ◽  
Clear Trend ◽  
Content Type ◽  
Functional Brain Mapping ◽  
Intractable Seizures ◽  
Neuropsychological Assessments ◽  
Subtotal Removal

✓ Gangliogliomas are indolent neoplasms that are often associated with long-standing intractable seizures. The seizure-free outcome following ganglioglioma resection alone (or “lesionectomy”) has been generally favorable, ranging in most series from 50% to 65%. Thus, the value of resection of epileptogenic cortex in addition to tumor with regard to seizure outcome has been the subject of controversy. The authors describe a series of 12 patients with frontal or temporal lobe gangliogliomas associated with long-standing intractable seizures. In these patients, intraoperative electrocorticography was used to guide the resection of epileptogenic cortex along with tumor. Functional brain mapping, interictal and ictal monitoring of seizures, as well as thorough neuropsychological assessments were performed prior to resection in all cases. Outcome with regard to seizures, tumor recurrence, and neurological deficits was assessed with a mean follow-up period of 3.1 years. There was universal freedom from seizures postoperatively in 11 patients in whom complete or near-complete resection of epileptogenic cortex was achieved. In one patient in whom complete tumor resection and subtotal removal of epileptogenic cortex was achieved, a 95% reduction in seizure frequency was identified. No tumor recurrence or neurological deficits were observed. In a subset of four patients, neuropsychological and cognitive function were evaluated pre- and postoperatively. In these four, a clear trend toward improvement was noted in most functions. Thus, resection of epileptogenic cortex along with tumor may improve seizure outcome in selected patients with tumor-associated epilepsy without engendering identifiable neurological or cognitive deficits attributable to the incremental resection.

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